Association of <i>Leptin</i> Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population

Tao, Sha‐Sha; Dan, Yi-Lin; Wu, Guo-Cui; Zhang, Qin; Zhang, Tianping; Fan, Yin‐Guang; Pan, Hai‐Feng

doi:10.1155/2020/3789319

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…Additionally, LAG-3+ regulatory T cells were in lower levels in the serum of RA patients that presented high disease activity than in healthy subjects. Due to these attributions, FGL1 can be used as a possible intervention target in treating RA with different disease activities [ 26 , 139 , 140 , 141 ].…”

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

“…Leptin, as an example, is an adipokine that associates highly with polymorphisms and is inclusive in its receptors. Along with the world’s different populations, specific types of genetic alterations may be found, and these may be or not be related to the RA disease activity, such as in the Chinese population, in which the leptin genes polymorphisms rs10244329, rs2071045, and rs2167270 are all not associated with RA genetic susceptibility [ 140 ]. Organokines secretion can also be affected by a polymorphism in genes of apolipoproteins (APO).…”

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

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Organokines in Rheumatoid Arthritis: A Critical Review

Laurindo

Maio

Barbalho

et al. 2022

IJMS

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Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints. Organokines can produce beneficial or harmful effects in this condition. Among RA patients, organokines have been associated with increased inflammation and cartilage degradation due to augmented cytokines and metalloproteinases production, respectively. This study aimed to perform a review to investigate the role of adipokines, osteokines, myokines, and hepatokines on RA progression. PubMed, Embase, Google Scholar, and Cochrane were searched, and 18 studies were selected, comprising more than 17,000 RA patients. Changes in the pattern of organokines secretion were identified, and these could directly or indirectly contribute to aggravating RA, promoting articular alterations, and predicting the disease activity. In addition, organokines have been implicated in higher radiographic damage, immune dysregulation, and angiogenesis. These can also act as RA potent regulators of cells proliferation, differentiation, and apoptosis, controlling osteoclasts, chondrocytes, and fibroblasts as well as immune cells chemotaxis to RA sites. Although much is already known, much more is still unknown, principally about the roles of organokines in the occurrence of RA extra-articular manifestations.

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Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

Organokines in Rheumatoid Arthritis: A Critical Review

Laurindo

Maio

Barbalho

et al. 2022

IJMS

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Circulating leptin and its correlation with rheumatoid arthritis activity: a meta-analysis

Lee

Song

2023

J Rheum Dis

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The aim of the study was to investigate the association between the levels of leptin in the circulating of individuals with rheumatoid arthritis (RA) and the severity of the disease. Methods: We looked through the databases of Embase, Medline, and the Cochrane Library. We conducted a meta-analysis on the correlations between circulating leptin and the Disease Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR) and Creactive protein (CRP) levels in RA patients, as well as a meta-analysis of circulating or circulating leptin levels in RA patients. Results: This meta-analysis study analyzed 42 different comparisons from 37 different publications, including a total of 2,350 patients with RA and 1,815 controls. The RA group had substantially higher leptin levels than the control group (standardized mean difference [SMD]=0.507, 95% confidence interval [CI]=0.309~0.704, p<0.001). The finding that RA patients had higher leptin levels was unaffected by sample size. The correlation between circulating leptin levels and DAS28 is statistically significant (correlation coefficient=0.247, 95% CI=0.087~0.396, p=0.003). Leptin levels are also correlated with CRP levels (correlation coef-ficient=0.203, 95% CI=0.048~0.349, p=0.010). Conclusion:This comprehensive meta-analysis demonstrates that the circulating leptin levels of RA patients are elevated, and provides compelling evidence of the significant relationship between leptin levels and the activity of RA. The findings of this research suggest that leptin plays a significant role in the pathophysiology of this disease.

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Association of Leptin Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population

Cited by 2 publications

References 48 publications

Organokines in Rheumatoid Arthritis: A Critical Review

Organokines in Rheumatoid Arthritis: A Critical Review

Circulating leptin and its correlation with rheumatoid arthritis activity: a meta-analysis

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