Association of Leukocyte and Neutrophil Counts With Infarct Size, Left Ventricular Function and Outcomes After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction

Chia, Stanley; Nagurney, John Tobias; Brown, David F.M.; Raffel, Corey; Bamberg, Fabian; Senatore, Fred; Wackers, Frans J. Th.; Jang, Ik‐Kyung

doi:10.1016/j.amjcard.2008.09.085

Cited by 181 publications

(140 citation statements)

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“…In this study, we found that WBC count was associated with MACE-free survival rate at longterm follow-up, but it did not predict outcomes. These findings are consistent with previous studies showing the prognostic role of leukocyte differentials, including total WBC count, neutrophil count, lymphocyte, or neutrophil to lymphocyte ratio in patients with STEMI [22][23][24][25], NSTE-ACS [8], or NSTEMI [26]. Although the prognostic value of total WBC count has been reported in previous literatures, the superiority of WMR over WBC count was demonstrated in the present study by both the stronger probability of MACE-free survival rate and the multivariate analysis.…”

Section: Discussionsupporting

confidence: 77%

White blood cell count to mean platelet volume ratio as a novel non-invasive marker predicting long-term outcomes in patients with non-ST elevation acute coronary syndrome

2015

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(p < 0.001). In an adjusted cox regression model, the elevated WMR was independently predicted the incidence of MACE (hazard ratio 2.419, p < 0.001). Conclusions:The elevated baseline WMR independently predicted the MACE incidence in patients with NSTE-ACS during long-term follow-up. (Cardiol J 2015; 22, 4: 437-445) Key words: white blood cell to mean platelet volume ratio, non-ST elevation acute coronary syndrome, major adverse cardiovascular events

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Section: Discussionsupporting

confidence: 77%

White blood cell count to mean platelet volume ratio as a novel non-invasive marker predicting long-term outcomes in patients with non-ST elevation acute coronary syndrome

2015

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“…Age > 70 years has remained a major independent predictor of in-hospital cardiovascular mortality in many STEMI prognosis studies [21]. Similar to our cohort where NLR > 7.4 was independently associated with systolic heart failure, studies have shown that increased neutrophil count has been reliably associated with increased MI size and decreased left ventricular function [22]. Evidence of CHF with elevated BNP levels is associated with poor prognosis due to increased myocardial damage [23].…”

Section: Discussionsupporting

confidence: 68%

Neutrophil to lymphocyte ratio predicts short- and long-term mortality following revascularization therapy for ST elevation myocardial infarction

et al. 2014

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(OR = 5.35, p < 0.001), cerebrovascular accident history (OR = 3.36, p = 0.023), low glomerular filtration rate (OR = 0.98, p = 0.012) and cardiac arrest on admission (OR = 17.43, p < 0.001) as robust independent predictors of long-term mortality. NLR was divided into two sub-groups based on an optimal cut off value of 7.4. This provided the best discriminatory cut off point for predicting adverse mortality outcome. (Cardiol J 2014; 21, 5: 500-508)

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“…In addition, the protective effects of CAPE against myocardial and hepatic injuries have been shown, which are partly mediated by the inhibition of inflammatory responses (27,28). The data obtained from recent studies showed that the leukocyte and neutrophil counts directly reflect the extent of myocardial damage in humans (29). In a similar way, researchers have demonstrated that neutrophils may contribute to tissue injury by the release of leukotrienes, free oxygen radicals and hydrolytic enzymes in ISO induced MI (11,30).…”

Section: Discussionmentioning

confidence: 70%

Effects of caffeic acid phenethyl ester on isoproterenol-induced myocardial infarction in rats

Oktar¹,

Aydın²,

Yönden³

et al. 2010

Anadolu Kardiyol Derg

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ÖZETAmaç: Kafeik asit fenetil ester (CAPE) güçlü antiinflamatuvar, anti-tümör ve antioksidan özelliklere sahip doğal bir üründür ve iskemireperfüzyonun indüklediği inflamasyonu ve lipid peroksidasyonu azaltır. Bu çalışmanın amacı isoproterenol (ISO) indüklü miyokardiyal infarktüs üzerine CAPE tedavisinin etkilerini incelemektir. Yöntemler: Bu çalışmada rasgele deneysel kontrollü araştırma dizaynı seçildi. Sıçanlar dört gruba ayrıldı: Kontrol, CAPE, ISO, ISO+CAPE. CAPE (10 μmol kg/gün i.p.) ve ISO (150 mg /kg s.c.) tek başlarına ratlara 7 gün süreyle verildi. ISO+CAPE grubunda ise ratlara ISO (150 mg /kg s.c.) uygulamasından 3 gün önce CAPE (10 μmol kg/gün i.p.) verilmeye başlandı. Yedi günlük deney periyodunun sonunda ratlar öldürüldü ve biyokimyasal analizler için kan ve doku örnekleri alındı. Verilerin istatistiksel analizi tek-yönlü ANOVA ve post-hoc LSD testi ile yapıldı. Bulgular: Tek başına ISO uygulanması sonucu myeloperoksidaz (MPO) aktivitesi, lipid peroksidasyonu, süperoksit dismutaz (SOD) ve katalaz (CAT) aktiviteleri arttı. Tek başına CAPE uygulaması ise enzim değerlerini kontrole göre değiştirmedi. CAPE tedavisi verilen grupta ise MPO aktivitesi ve malondialdehit seviyesi düşerken, CAT ve SOD aktivitesi değişmedi. Sonuç: Mevcut bulgular CAPE tedavisinin nötrofil MPO aktivitesini inhibe ederek MPO ve lipid peroksidasyon aracılı miyokardiyal hasarı önle-diğine işaret etmektedir. (Anadolu Kardiyol Derg 2010; 10: 298-302) Anahtar kelimeler: Kafeik asit fenetil ester, isoproterenol, lipid peroksidasyonu, miyokardiyal infarktüs, oksidatif stres, miyeloperoksidaz ABSTRACT Objective: Caffeic acid phenethyl ester (CAPE) is a natural product with potent anti-inflammatory, antitumor and antioxidant activities and attenuates inflammation and lipid peroxidation induced by ischemia-reperfusion injury. The purpose of the present study was to investigate the effects of CAPE on isoproterenol (ISO) -induced myocardial infarction. Methods: A randomized controlled experimental design was used in this study. Rats were divided into four groups and treated with saline, CAPE, ISO and ISO+CAPE. Rats were treated with CAPE (10 μmol kg/day i.p.) or saline starting 3 days before injecting ISO (150 mg /kg s.c., 24 hours). Seven days later, rats were sacrificed and the hearts were excised for biochemical analyses and microscopic examination. One-way ANOVA test with post hoc multiple comparisons using LSD method were used for statistical analysis of the data. Results: The administration of ISO alone resulted in higher myeloperoxidase (MPO) activity, lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) than in the control. The enzyme activities did not change in rat given CAPE alone. CAPE treatment prevented the increase in MPO activity and malondialdehyde, but did not affect the activities SOD and CAT enzymes. Conclusion: In light of these results, we conclude that CAPE prevents MPO-and lipid peroxidation-mediated myocardial injury via inhibition of neutrophil's MPO activity. (Anadolu Kardiyol Derg 2010; 10: 298-302)

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Association of Leukocyte and Neutrophil Counts With Infarct Size, Left Ventricular Function and Outcomes After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction

Cited by 181 publications

References 20 publications

White blood cell count to mean platelet volume ratio as a novel non-invasive marker predicting long-term outcomes in patients with non-ST elevation acute coronary syndrome

White blood cell count to mean platelet volume ratio as a novel non-invasive marker predicting long-term outcomes in patients with non-ST elevation acute coronary syndrome

Neutrophil to lymphocyte ratio predicts short- and long-term mortality following revascularization therapy for ST elevation myocardial infarction

Effects of caffeic acid phenethyl ester on isoproterenol-induced myocardial infarction in rats

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