Association of lichen planus with hepatitis C virus infection

Asaad, Tonsi; Samdani, Azam Jah

doi:10.5144/0256-4947.2005.243

Cited by 20 publications

(6 citation statements)

References 18 publications

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“…Bagan et al found that 14.9% of patients with OLP had antibodies to HCV in a study population of 187 patients. [17] Several authors have reported an increased prevalence of CLD in patients with LP and association with Hepatitis C. [4][5][6][7] However, studies from our country and other parts of South Asia did not find an association of LP with HCV infection. [18,19] Our findings showed an association between patients with OLP and HCV infection, which could be due to differences in genetic, environmental, geographic, or other host factors as described earlier.…”

Section: Discussionmentioning

confidence: 81%

“…[4,5] Recent reports suggest an association between hepatitis C virus (HCV)-related CLD and oral lichen planus (OLP). [6,7] HCV is a hepatotropic, single-stranded ribonucleic acid (RNA) virus and has been associated with extrahepatic manifestations and autoimmune diseases, like LP, polyarteritis nodosa, and erythema nodosum. [8] The prevalence of HCV infection among general population in various states of India ranges between 0.1 and 7.9%.…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis C virus infection in patients with oral lichen planus

Konidena

Pavani²

2011

Niger J Clin Pract

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Hepatitis C virus infection in patients with oral lichen planus

Konidena

Pavani²

2011

Niger J Clin Pract

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“…Literature yielded a total of 18,491 references, and once duplicates were excluded ( n = 5822), 234 studies were full-text reviewed. In total, 192 studies were included in the systematic review, of which 99 studies were included in the quantitative analysis, shown in Figure 1 [ 8 , 10 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , …”

Section: Resultsmentioning

confidence: 99%

Bidirectional Association between Lichen Planus and Hepatitis C—An Update Systematic Review and Meta-Analysis

García-Pola,

Rodríguez-Fonseca,

Suárez-Fernández

et al. 2023

JCM

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Lichen planus (LP) is a chronic, inflammatory mucocutaneous disorder associated with systemic diseases such as hepatitis C (HCV). The objective of this study is to evaluate the association between LP and HCV bidirectionally through a systematic review and meta-analysis. A comprehensive search of studies published was performed in the databases of PubMed, Embase, and Web of Science. Out of 18,491 articles, 192 studies were included. The global prevalence of HCV positive (HCV+) in LP patients registered from 143 studies was 9.42% [95% confidence interval (CI), 7.27–11.58%], and from these, 84 studies showed HCV+ 4-fold more frequent in LP than a control group (OR, 4.48; 95% CI, 3.48–5.77). The global prevalence of LP in patients HCV+ recorded from 49 studies was 7.05% (95% CI, 4.85–9.26%), and from these, 15 registered a 3-fold more LP in HCV (OR, 3.65; 95% CI, 2.14–6.24). HCV+ in LP patients showed great geographic variability (OR, 2.7 to 8.57), and the predominantly cutaneous location was higher (OR, 5.95) than the oral location (OR, 3.49). LP in HCV+ patients was more frequent in the Eastern Mediterranean (OR, 5.51; 95% CI, 1.40–15.57). There is a higher prevalence of HCV+ in LP and vice versa than in the control group, especially in certain geographical areas that should be taken into consideration when doing screening in countries with an upper prevalence of HCV among the general population.

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“…7,10,12,15 HCV was more frequently associated with oral LP from Thailand, Pakistan and Saudi Arabia. 8,9,38 In India, studies conducted at Calicut, Kolkata, New Delhi, have failed to demonstrate a statistically significant association whereas studies conducted at Hyderabad and Bangalore have shown a significant association. 16 Pavani et al from Telangana had reported HCV infection in 12% of their Oral LP patients, 18 but a study from Puducherry did not show any association 16 The association was not consistent.…”

Section: Discussionmentioning

confidence: 99%

A cross sectional study of lichen planus: It’s epidemiological, clinico-histopathogical and serological perspective

Sneha¹,

Seetharamanjaneyulu²,

Ramana³

et al. 2020

IJCED

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Lichen planus (LP) is a common papulosquamous skin disease with a prevalence 1-2% globally and 0.1 - 1.5% in Indian studies with many morphological presentations. LP is strongly associated with chronic HCV infection (3.1- 18.3% in different studies), while the association with other viral infections (Hepatitis B and HIV) is not that strong. There are only a few studies in Indian patients and the association reported is not uniform. Further studies will help to consolidate the association.1) To study the epidemiological and clinico- histopathological pattern in LP. 2) To determine the serology and assess the possible association with HCV, HBsAg and HIV.140 patients of LP after histopathological confirmation were tested for detection of HCV antibodies, Hbs antigen and HIV antibodies by HCV-TRIDOT, HEPACARD and HIV –TRIDOT respectively. Statistical analysis was performed by SPSS software 20.0.Most common age group involved was 21-30 years. 75.6% of the patients presented with in 6 months of onset. Extremities and trunk were commonly involved. The most common clinical variants are classical LP(35%) and hypertrophic LP(31%). Mucosal involvement alone was observed in 9.3% patients . HBs Ag was positive in 4 cases , Anti HCV antibodies were positive in 3 cases and HIV was reactive in 3 cases.There is no significant relationship between LP and Hepatitis B, C and HIV virus. It may be suggested that viral serology (HBV, HCV, HIV) may not be necessary in routine screening for LP.

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Association of lichen planus with hepatitis C virus infection

Cited by 20 publications

References 18 publications

Hepatitis C virus infection in patients with oral lichen planus

Hepatitis C virus infection in patients with oral lichen planus

Bidirectional Association between Lichen Planus and Hepatitis C—An Update Systematic Review and Meta-Analysis

A cross sectional study of lichen planus: It’s epidemiological, clinico-histopathogical and serological perspective

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