Association of low-dose naltrexone and transcranial direct current stimulation in fibromyalgia: a randomized, double-blinded, parallel clinical trial

Paula, Tânia Maria Hendges de; Castro, Mariane Schäffer; Medeiros, Liciane Fernandes; Paludo, Rodrigo Hernandes; Couto, Fabricia Fritz; Costa, Tainá Ramires da; Fortes, Juliana Pereira; Salbego, Maiara de Oliveira; Behnck, Gabriel Schardosim; Moura, Thielly Amaral Mesquita de; Tarouco, Mariana Lenz; Caumo, Wolnei; Souza, Andressa de

doi:10.1016/j.bjane.2022.08.003

Cited by 9 publications

(8 citation statements)

References 32 publications

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“…A total of nineteen studies used NIBS to treat fibromyalgia (4 rTMS, 13 tDCS, 1 HD-tDCS, 1 Reduced Impedance Noninvasive Cortical Electrostimulation, RINCE, a method that applies electrical currents via scalp electrodes with specific stimulation frequencies hypothesized to reduce electrical impedance from skin and skull tissues, which may facilitate deeper cortical penetration and modulation of lower-frequency cortical activity [ 44 , 45 ]) [ 19 , 44 , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] ]. For rTMS studies, the coil was commonly placed over the left M1 (C3) and right DLPFC (F4) [ [56] , [57] , [58] ].…”

Section: Resultsmentioning

confidence: 99%

Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review

Kong,

Li,

Reddy

et al. 2024

Neurotherapeutics

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Section: Resultsmentioning

confidence: 99%

Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review

Kong,

Li,

Reddy

et al. 2024

Neurotherapeutics

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“…We identified thirty-five studies reporting the use of tDCS to improve fibromyalgia symptoms (mainly pain intensity), and some of these studies correlated symptomatic improvements with changes in neurobiological measures. The specific protocols followed in each study and the respective results are shown in Table 3 [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ].…”

Section: Resultsmentioning

confidence: 99%

Non-Invasive Electric and Magnetic Brain Stimulation for the Treatment of Fibromyalgia

et al. 2023

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Although fibromyalgia is defined by its core muscular nociceptive component, it also includes multiple dysfunctions that involve the musculoskeletal, gastrointestinal, immune, endocrine, as well as the central and peripheral nervous systems, amongst others. The pathogenic involvement of the nervous system and the numerous neurological and neuroinflammatory symptoms of this disease may benefit from neuromodulatory stimulation techniques that have been shown to be effective and safe in diverse nervous system pathologies. In this systematic review, we outline current evidence showing the potential of non-invasive brain stimulation techniques, such as therapeutic strategies in fibromyalgia. In addition, we evaluate the contribution of these tools to the exploration of the neurophysiological characteristics of fibromyalgia. Considering that the pathogenesis of this disease is unknown, these approaches do not aim to causally treat this syndrome, but to significantly reduce a range of key symptoms and thus improve the quality of life of the patients.

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“…Finally, psychological, cognitive, and emotional factors will be measured, such as kinesiophobia [38,39], anxiety [40], depression [41], psychological distress [42], and selfefficacy [43][44][45]. For this purpose, we will use the Tampa scale of kinesiophobia (TSK), the state-trait anxiety inventory (STAI), the Beck depression inventory II (BDI-II), and the chronic pain self-efficacy questionnaire (PSEQ), all of them translated and validated in Spanish [45,46].…”

Section: Psychological Cognitive and Emotional Factorsmentioning

confidence: 99%

What Concept of Manual Therapy Is More Effective to Improve Health Status in Women with Fibromyalgia Syndrome? A Study Protocol with Preliminary Results

Audoux

Estrada-Barranco

Martínez-Pozas

et al. 2023

IJERPH

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Background: Fibromyalgia (FM) is defined as a chronic syndrome characterized by diffuse musculoskeletal pain, associated with characteristic signs and symptoms such as fatigue and/or sleep and mood disorders, and whose etiology, pathogenesis and prognosis may or may not be known. There is growing evidence of manual therapy as a treatment for pain in the short and medium term, also in patients affected by FM. However, the heterogeneity of the manual therapy treatments administered are a very common clinical practice, as they are based more on the judgment or tendency of the physiotherapist, rather than on clear scientific evidence. Therefore, the aim of the present study protocol will be to determine which manual therapy approach is more effective in addressing health status by improving symptoms (sensory, cognitive, emotional and social) in patients with FM. Methods: a randomized controlled clinical trial with a 3-month follow-up will be carried out with 52 female patients affected by rheumatologist-diagnosed FM will be recruited and evaluated at the Asociación de Fibromialgia y Síndrome de Fatiga Crónica (AFINSYFACRO) in Móstoles, Madrid, Spain. For more details on the protocol, a pilot study was carried out using a non-probability method of judgmental or purposive sampling. Thirteen patients were also evaluated, treated and reevaluated; eight patients were assigned to the myofascial techniques approach (MTA) group and five to the Maitland’s mobilization approach (MMA) group. Results: the preliminary results presented here are intended to show how the planned randomized controlled clinical trial will develop. Patients who received MTA had significantly improved pain and health status outcomes after treatment and at 1-month follow-up, with no significant change in those who received MMA. Conclusions: the exact details of the study protocol on which the manual therapy approach is more effective in addressing health status by improving symptoms (sensory, cognitive, emotional, and social) in patients with FM are presented. Preliminary results show that manual therapy is effective in improving pain and health status in patients with fibromyalgia at short and medium term, with significant results in those who received MTA.

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Association of low-dose naltrexone and transcranial direct current stimulation in fibromyalgia: a randomized, double-blinded, parallel clinical trial

Cited by 9 publications

References 32 publications

Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review

Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review

Non-Invasive Electric and Magnetic Brain Stimulation for the Treatment of Fibromyalgia

What Concept of Manual Therapy Is More Effective to Improve Health Status in Women with Fibromyalgia Syndrome? A Study Protocol with Preliminary Results

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