Association of low serum 25-hydroxyvitamin D levels and high arterial blood pressure in the elderly

Almirall, Jaume; Vaqueiro, Montserrat; Baré, Marisa; Anton, Esperanza

doi:10.1093/ndt/gfp470

Cited by 51 publications

(42 citation statements)

References 37 publications

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“…This state of calciferol insufficiency is replicated in Spain, with results which we show in table 1 [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] . The interlaboratory variation in the different methodologies used makes a rigorous comparison difficult, but the table illustrates clearly that, in spite of a theoretical climatological ease of vitamin D synthesis in Spain, the levels are similar to, or even lower than those reported for central Europe or Scandinavia, as has been described in earlier works 39 .…”

Section: State Of Vitamin D Insufficiency In Spainmentioning

confidence: 55%

“…Most of Spain is above the 35ºN parallel where the possibility of synthesising vitamin D in winter and spring is low, and because most Spanish people have darker skin which makes the synthesis of vitamin D more difficult 39 . We observed that in Spain, as in the rest of the world, insufficiency, or even true deficiency in vitamin D is already found in children or young people, and persists in adults, postmenopausal women (osteoporotic or not), and in older people who live in their own homes, and that it is even higher if they live in residential homes, with a seasonal variation which barley reaches normal levels after summer-autumn [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] . Although this high prevalence of low levels of vitamin D occurs due to inadequate exposure to sunlight, in older Spanish people lower levels have been described in the summer months due to the high temperatures which occur in the cities of southern Spain such as Murcia or Cordoba at this time of year, which are commonly between 30 and 40° C. The older people avoid being in the sun and prefer to remain indoors where the temperature is more comfortable.…”

Section: State Of Vitamin D Insufficiency In Spainmentioning

confidence: 99%

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Deficiencia de vitamina D en España: ¿realidad o mito?

Valverde

Gómez

2014

Rev Osteoporos Metab Miner

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Vitamin D 3 (colecalciferol) is formed from its precursor 7-dehydrocholesterol in the skin by ultraviolet irradiation. In the liver the vitamin D 3 is hydroxylated to form 25-hydroxyvitamin D 3 , which is metabolised to its active metabolite 1,25-dihydroxyvitamin D 3 preferentially in the kidney. Vitamin D 3 may also be provided in the diet, which is a significant source of supply only in the case of insufficient exposure to sunlight. Blue fish naturally contains large quantities of vitamin D 3 , while other foods contain significant quantities of vitamin D only after being fortified. For fortification, in many countries vitamin D 2 is used (ergocalciferol) obtained from vegetable sources 1 . The presence of the enzyme CYP27B1, which drives the synthesis of dihydroxyvitamin D from its principal substrate, 25-hydroxyvitamin D, and the vitamin D receptor (VDR), distributed almost universally in the cells and tissues of the organism, confers on vitamin D (although it would be increasingly more correct to say the endocrine system of vitamin D) a broad role in health. This is not only in the regulation of calcium and bone metabolism but also in relation to the cardiovascular system, innate or acquired immunomodulation, the regulation of cell growth, etc., such that around 3% of the human genome is regulated by the hormone 1,25(OH) 2 vitamin D 3 1-3 . It is therefore not surprising that basic scientific and clinical interest in vitamin D 4 , as well as interest in the non-specialist press and in the general population 5 , has increased almost exponentially in the last decade. 25-hydroxyvitamin D, marker for the status of vitamin D in the bodyFor some years there has been universal consensus that the measurement of the levels of the metabolite 25-hydroxyvitamin D in the blood is the marker for the status of vitamin D in the body, including the endogenous synthesis due to exposure to sunlight, dietary consumption in foods, supplemented or not, and pharmacological treatments 1,2

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Section: State Of Vitamin D Insufficiency In Spainmentioning

confidence: 55%

Section: State Of Vitamin D Insufficiency In Spainmentioning

confidence: 99%

Deficiencia de vitamina D en España: ¿realidad o mito?

Valverde

Gómez

2014

Rev Osteoporos Metab Miner

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“…Regarding blood pressure, data from NHANES III (USA) showed an inverse correlation between SBP and vitamin D [12], and other studies have shown similar associations [37] [38]. The role of vitamin D in the reninangiotensin-aldosterone system is the most plausible explanation for the results [13].…”

Section: Discussionmentioning

confidence: 69%

Cardiovascular Risk of Community-Dwelling Elderly from a City in Northeastern Brazil: Correlations with Vitamin D and Parathormone

Carvalho¹,

Carvalho²,

Ribeiro³

et al. 2014

FNS

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We investigated the cardiovascular disease (CVD) risk of the elderly in a city in northeastern Brazil, and the correlation of this risk with vitamin D and PTH status. We studied 359 elderly, both genders, from Piauí-Teresina-Brazil. Variables investigated: body mass index, waist circumference, systolic and diastolic blood pressure. A subsample (n = 100) was investigated for biochemical analyses: PTH and 25(OH)-vitamin D levels; total, HDL and LDL-cholesterol; and fasting glucose. High blood pressure, abdominal obesity, sedentarism, high total cholesterol, high triacylglycerol levels, as well as low vitamin D levels, were, among the investigated variables, the most prevalent. Visceral adiposity and low vitamin D were found to be more prevalent in women than in men, whilst alcohol intake and smoking were more prevalent in men. The correlation between vitamin D, PTH and the investigated risk variables, under our study conditions, were not significant.

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“…50,51 The inverse relationship between levels of Vit D and hypertension has been assessed in several studies. [52][53][54] It is slightly more clear whether supplementation of Vit D decreases arterial pressure. 55,56 In our study, SBP and DBP levels were higher in individuals with MS than without MS.…”

Section: Resultsmentioning

confidence: 99%

Relationship Between Levels of Vitamin D and Metabolic Syndrome Parameters in Patients with Metabolic Syndrome and Healthy Individuals

Evrim¹,

Atalay²,

Gürsoy³

et al. 2016

Turkiye Klinikleri J Endocrin

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A AB BS S TTR RA AC CT T O Ob bj je ec ct ti iv ve e: : Hypovitaminosis D and metabolic syndrome are worldwide common problems. The link between them was unresolved. We planned to define the relation between Vitamin D levels and metabolic syndrome and also their parameters. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : We evaluated all the demographic and anthropometric parameters of 79 healthy participants and 95 patients with metabolic syndrome and compared those parameters and vitamin D levels. We classified 25(OH)D serum levels; <10ng/mL as serious deficiency, 10-20 ng/mL as deficiency, 20-30 ng/mL insufficiency and > 30 ng/mL as normal status. We searched the correlation of vitamin D levels with metabolic syndrome parameters. We also examined the relation of various Vitamin D levels with demographic and anthropometric findings of metabolic syndrome patients. R Re es su ul lt ts s: : Vitamin D levels were low in all the individuals (12.8 ± 6.7ng/mL in patients and 19.0 ± 10.0ng/mL in controls. p<0.001). In metabolic syndrome patients, serious deficiency was high and normal Vit D status was significantly low especially in females. In metabolic syndrome group vitamin D levels were negatively correlated with body mass index, waist circumference, blood glucose, hemoglobin A1c, fasting insulin, insulin resistance index (p <0.012, <0.040, <0.002, <0.008, <0.006, <0.001 respectively). We found that vitamin D levels of the patients without hypertension, diabetes mellitus, dyslipidemia or obesity were higher than that of the patients with those diseases among metabolic syndrome group (all p<0.001). We also demonstrated as Vitamin D levels decreased, rate of obesity, hypertension and diabetes mellitus increased, (p<.0.029, <0.035 and <0.001 respectively). C Co on nc cl lu us si io on n: : In patients with metabolic syndrome hypovitaminosis D is frequent especially in women. As Vitamin D levels are in negative correlation with obesity, diabetes and insulin resistance indices and also with metabolic syndrome parameters, we concluded that Vitamin D supplementation is important in hypovitaminosis D cases with metabolic syndrome. Ya zış ma Ad re si/Cor res pon den ce:

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Association of low serum 25-hydroxyvitamin D levels and high arterial blood pressure in the elderly

Cited by 51 publications

References 37 publications

Deficiencia de vitamina D en España: ¿realidad o mito?

Deficiencia de vitamina D en España: ¿realidad o mito?

Cardiovascular Risk of Community-Dwelling Elderly from a City in Northeastern Brazil: Correlations with Vitamin D and Parathormone

Relationship Between Levels of Vitamin D and Metabolic Syndrome Parameters in Patients with Metabolic Syndrome and Healthy Individuals

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