Deficiencia de vitamina D en España: ¿realidad o mito?

Valverde, Cristina Navarro; Gómez, José Manuel

doi:10.4321/s1889-836x2014000500002

Cited by 26 publications

(11 citation statements)

References 76 publications

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“…In this study, we found a high prevalence (89.9%) of deficient or insufficient serum levels of vitamin D (serum 25(OH)D3, <30 ng/mL) in a group of 273 elderly subjects, representative of a healthy age-related Spanish population. Our results are similar to previous studies in Spanish populations [19,20,21,22].…”

Section: Discussionsupporting

confidence: 93%

Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People

et al. 2019

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As the relationship between vitamin D and various diseases or health conditions has become known, interest in the contribution of vitamin D to overall health-related quality of life (QoL) has increased. We examined the relationship between vitamin D status and QoL in 273 participants aged 65 years and older. Serum levels of total calcium, phosphorus, intact parathyroid hormone, albumin, and 25-hydroxyvitaminD3 were analyzed. We also recruited data for QoL, physical activity, nutritional impairment, and muscular strength. Ninety percent of the subjects were classified as vitamin D deficient or insufficient. Participants with higher serum 25(OH)D3, calcium, phosphorous, and Alb levels were significantly less likely to self-report depression or anxiety after adjustment (p = 0.009, p = 0.005, p = 0.003, and p = 0.005, respectively). Additionally, we found an association between lower levels of albumin and self-reported problems with mobility or usual activities (p = 0.01). We also found associations between better muscle strength and higher levels of vitamin D, calcium, phosphorous, and albumin (p = 0.006, p = 0.003, p = 0.004 and p = 0.002, respectively). Overall, our data provide evidence that serum vitamin D and Alb levels are negatively related to self-reported anxiety or depression, usual activities, mobility, and three dimensions of QoL in older adults. Furthermore, vitamin D levels are positively related to hand grip strength in adults over 65 years old.

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Section: Discussionsupporting

confidence: 93%

Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People

et al. 2019

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“…Mean serum 25(OH) concentration in our study was similar to that reported in other European countries [18], similar to that detected in small studies carried out in different Spanish regions [8] and slightly lower than the concentration detected in larger Spanish studies, where the average levels fluctuated between 56 and 62 nmol/L [19][20][21]. The prevalence of vitamin D deficiency (<50nmol/L) in our study (55% in controls and 69% in BC cases) was higher than that reported among pre and post Mexican women (36%) [22], higher than the reported at European level (40%) [18], and also higher than that reported in other Spanish studies [19][20][21]23], but much [26,27], while the most recent reported a weak and nonsignificant inverse association [12].…”

Section: Accepted Manuscriptsupporting

confidence: 92%

“…behavior, use of UV protection cream and air pollution with ozone and nitrogen dioxide, which reduce suninduced vitamin D production [7,8].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Serum 25-hydroxyvitamin D and breast cancer risk by pathological subtype (MCC-Spain)

Lope

Castelló

Mena-Bravo

et al. 2018

The Journal of Steroid Biochemistry and Molecular Biology

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Epidemiologic evidence on the association between vitamin D and breast cancer is still inconclusive. This study analyzes the association between serum 25-hydroxyvitamin D (25(OH)D) and breast cancer risk by pathologic subtype, stage at diagnosis and specific breast cancer risk factors. We conducted a population-based multicase-control study where 546 histologically-confirmed breast cancer cases and 558 population controls, frequently matched by geographic area, age and body mass index, were recruited in 12 Spanish provinces (MCC-Spain). Information was collected by a questionnaire and plasma 25(OH)D was measured by solid-phase extraction on-line coupled to liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS). Odds ratios and 95% confidence intervals were calculated using logistic and multinomial mixed regression models. We found a clear protective effect between 25(OH)D levels and breast cancer risk, with a significant dose-response trend (OR per 10 nmol/L = 0.88; 95%CI = 0.82-0.94). While no differences were observed between pre and postmenopausal women, stage at diagnosis, or across strata of the main breast cancer risk factors, the protection was more pronounced for triple negative tumors (OR per 10 nmol/L = 0.64; p-heterogeneity = 0.038). Similar results were observed when only cases sampled in the first month after diagnosis were considered. The protective effect of vitamin D on breast cancer risk may be subtype specific, being stronger for more aggressive tumors, which provides a new approach to prevent this disease.

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“…Another factor to consider could be the level of vitamin D: in one meta-analysis, review authors observed an inverse association between vitamin D levels and the incidence of COPD exacerbations and a protective role for vitamin D supplements in patients with COPD and vitamin D deficiency [ 25 ]. In an earlier study, authors observed low levels of vitamin D in the female population of Spain [ 26 ]. Finally, numerous studies across different pathologies have found that women are at greater risk of not adhering to treatment, which could also have an impact on disease control [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Trends in Hospital Admissions for Chronic Obstructive Pulmonary Disease in Men and Women in Spain, 1998 to 2018

Orozco‐Beltrán

Arriero-Marín

Carratalá‐Munuera

et al. 2021

JCM

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The prevalence of chronic obstructive pulmonary disease (COPD) is rising faster in women in some countries. An observational time trends study was performed to assess the evolution of hospital admissions for COPD in men and women in Spain from 1998 to 2018. ICD-9 diagnostic codes (490–492, 496) from the minimum basic data set of hospital discharges were used. Age-standardised admission rates were calculated using the European Standard Population. Joinpoint regression models were fitted to estimate the annual percent change (APC). In 2018, the age-standardised admission rate per 100,000 population/year for COPD was five times higher in men (384.8, 95% CI: 381.7, 387.9) than in women (78.6, 95% CI: 77.4, 79.9). The average annual percent change (AAPC) was negative over the whole study period in men (−1.7%/year, 95% CI: −3.1, −0.2) but positive from 2010 to 2018 (1.1%/year, 95% CI: −0.8, 2.9). In women, the APC was −6.0% (95%CI: −7.1, −4.9) from 1998 to 2010, but the trend reversed direction in the 2010–2018 period (7.8%/year, 95% CI: 5.5, 10.2). Thus, admission rates for COPD decreased from 1998 to 2010 in both men and women but started rising again until 2018, modestly in men and sharply in women.

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Deficiencia de vitamina D en España: ¿realidad o mito?

Cited by 26 publications

References 76 publications

Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People

Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People

Serum 25-hydroxyvitamin D and breast cancer risk by pathological subtype (MCC-Spain)

Trends in Hospital Admissions for Chronic Obstructive Pulmonary Disease in Men and Women in Spain, 1998 to 2018

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