Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People

Verde, Zoraida; Giaquinta, Andrea; Moreno-Sainz, Carmelo; Ondina, Marta Díaz; Araque, Ana Fernández

doi:10.3390/nu11112748

Cited by 14 publications

(11 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides, vitamin D (Vit D) may play a role between muscle and cognitive function. Vit D deficiency is strongly linked to muscle weakness and loss, suggesting that hypovitaminosis D in the elderly may be an important factor in the development of sarcopenia (Berchtold et al, 2000 ; Lappe and Binkley, 2015 ; Verde et al, 2019 ). It is found that the Vit D receptor is also expressed in the central nervous system (CNS) and that CNS is able to synthetize calcitriol per se due to the expression of the 25-hydroxylase and 1α-hydroxylase, which has raised the hypothesis that Vit D may have a role in brain health and in cognitive performance (D'amelio and Quacquarelli, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Grip Strength and the Risk of Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies

Cui

Zhang

Liu

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

Purpose: Loss of grip strength and cognitive impairment are prevalent in the elderly, and they may share the pathogenesis in common. Several original studies have investigated the association between them, but the results remained controversial. In this systematic review and meta-analysis, we aimed to quantitatively determine the relationship between baseline grip strength and the risk of cognitive impairment and provide evidence for clinical work.Methods: We performed a systematic review using PubMed, EMBASE, Cochrane, and Web of Science up to March 23, 2020, and focused on the association between baseline grip strength and onset of cognitive impairment. Next, we conducted a meta-analysis using a hazard ratio (HR) and 95% confidence interval (CI) as effect measures. Heterogeneity between the studies was examined using I2 and p-value. Sensitivity analyses and subgroup analyses were also performed, and publication bias was assessed by Begg's and Egger's tests.Results: Fifteen studies were included in this systematic review. After sensitivity analyses, poorer grip strength was associated with more risk of cognitive decline and dementia (HR = 1.99, 95%CI: 1.71–2.32; HR = 1.54, 95%CI: 1.32–1.79, respectively). Furthermore, subgroup analysis indicated that people with poorer strength had more risk of Alzheimer's disease (AD) and non-AD dementia (HR = 1.41, 95%CI: 1.09–1.81; HR = 1.45, 95%CI: 1.10–1.91, respectively).Conclusions: Lower grip strength is associated with more risk of onset of cognitive decline and dementia despite of subtype of dementia. We should be alert for the individuals with poor grip strength and identify cognitive dysfunction early.

show abstract

Section: Discussionmentioning

confidence: 99%

Grip Strength and the Risk of Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies

Cui

Zhang

Liu

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Decorin (DCN) is one of several glycosaminoglycan (GAG) no-collagen proteins secreted by bones. It is characterized as a leucine-rich repetitive core protein in bone [ 60 ]. DCN can directly interact with TGF-β in a dynamic environment to affect cell migration [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Quantitative proteomics reveals the effect of Yigu decoction (YGD) on protein expression in bone tissue

Zhang

Yan

et al. 2021

Clin Proteom

View full text Add to dashboard Cite

Background Osteoporosis (OP) is a systemic bone disease characterized by decreased bone mass, destruction of the bone tissue microstructure, increased bone brittleness and an increased risk of fracture. OP has a high incidence rate and long disease course and is associated with serious complications. Yigu decoction (YGD) is a compound prescription in traditional Chinese medicine that is used to treat OP. However, its mechanism in OP is not clear. This study used a tandem mass tag (TMT)quantitative proteomics method to explore the potential bone-protective mechanism of YGD in an osteoporotic rat model. Materials and methods A rat model of OP was established by ovariectomy. Eighteen 12-week-old specific-pathogen-free female Wistar rats weighing 220 ± 10 g were selected. The eighteen rats were randomly divided into 3 groups (n = 6 in each group): the normal, model and YGD groups. The right femurs from each group were subjected to quantitative biological analysis. TMT quantitative proteomics was used to analyze the proteins extracted from the bone tissue of rats in the model and YGD groups, and the differentially expressed proteins after intervention with YGD were identified as biologically relevant proteins of interest. Functional annotation correlation analysis was also performed to explore the biological function and mechanism of YGD. Result Compared with the model group, the YGD group showed significant upregulation of 26 proteins (FC > 1.2, P < 0.05) and significant downregulation of 39 proteins (FC < 0.833, P < 0.05). Four important targets involved in OP and 5 important signaling pathways involved in bone metabolism were identified. Conclusions YGD can significantly increase the bone mineral density (BMD) of osteoporotic rats and may play a therapeutic role by regulating target proteins involved in multiple signaling pathways. Therefore, these results improve the understanding of the OP mechanism and provide an experimental basis for the clinical application of YGD in OP treatment.

show abstract

“…The relationship between Vit-D and quality of life has also been investigated in different disease populations other than CKD. It was shown that higher Vit-D levels reduced disease activity in patients with ulcerative colitis, and it provided a better muscle strength among patients over the age of 65, thus leading to a better quality of life [37,38]. In another study, it was shown that low 25(OH) D levels were associated with lower physical activity and a weaker mental activity [39].…”

Section: Discussionmentioning

confidence: 99%

The relationship between serum vitamin D levels and health-related quality of life in peritoneal dialysis patients

Yüksel

Aydın

2021

Int Urol Nephrol

View full text Add to dashboard Cite

Introduction We aimed to investigate the relationship between Vitamin D level and quality of life in patients undergoing peritoneal dialysis as renal replacement therapy. Methods 50 peritoneal dialysis patients aged between 18 and 73 years were included in this study. KDQOL-36 questionnaire was applied to rate the quality of life of the patients. This questionnaire consisted of 36 questions divided into five subscales. The patients were divided into two groups according to serum vitamin D levels. Patients with a serum 25(OH) D level < 20 ng/mL were identified as vitamin D deficiency group and those with a serum 25(OH)D level ≥ 20 ng/mL were identified as normal vitamin D group. ResultsThe patients had a mean age of 41.16 ± 16.05 years, 56% of them were females. The mean 25(OH) D levels of patients with 25 (OH) D levels < 20 ng/mL and those with ≥ 20 ng/mL were 10.50 ± 4.62 ng/mL and 25.55 ± 4.11 ng/mL, respectively. We found that all subscales of KDQOL-36 were lower with statistically significance in the group with Vitamin D (Vit-D) deficiency. Hemoglobin level was detected as independent risk factor for Symptom and problem list subscales and SF-12 physical component summary subscale (PCS) (P = 0.029, P = 0.047). Vit-D deficiency was detected as independent risk factors for kidney disease burden subscale and PCS (P = 0.035, P = 0.019). Hypertension was detected as independent risk factor for kidney disease burden subscale (P = 0.015). ConclusionOur study is the first to investigate the relationship between serum Vit-D level and quality of life by KDQOL-36 scale in peritoneal dialysis patients. We revealed that patients with low Vit-D levels had worse quality of life in all subscales.

show abstract

Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People

Cited by 14 publications

References 50 publications

Grip Strength and the Risk of Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies

Grip Strength and the Risk of Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies

Quantitative proteomics reveals the effect of Yigu decoction (YGD) on protein expression in bone tissue

The relationship between serum vitamin D levels and health-related quality of life in peritoneal dialysis patients

Contact Info

Product

Resources

About