Association of low serum creatinine, abnormal lipid profile, gender, age and ethnicity with type 2 diabetes mellitus in Trinidad and Tobago

Nayak, B. Shivananda; Butcher, Donna M.; Bujhawan, Shivanna; Chang, Dominique; Chang, Simone; Cabral-Samaroo, Diane; Cadan, Sandhya; Buchoon, Vanessa; Budhram, Lystra; Boyce, M Ayanna; Teelucksingh, S

doi:10.1016/j.diabres.2010.12.017

Cited by 17 publications

(13 citation statements)

References 7 publications

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“…The occurrence of hypercholesterolemia for lipid determinants[11] and the prevalence of dyslipidemia among the diabetics have been previously identified within Trinidad,[14] which was clearly seen in our research among the diabetic population.…”

Section: Discussionsupporting

confidence: 78%

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Controlling Lipids AIDS in the Prevention of Type 2 Diabetes, Hypertension, and Cardiovascular Diseases

2017

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Background:Abnormal lipid profiles are a characteristic feature of persons with chronic conditions in which the diabetic populations are recognized as the dominant group, regardless of gender and ethnicity worldwide. This study was conducted to identify and evaluate the abnormalities of serum lipid profiles in both nondiabetic and diabetic persons.Methods:This study was a case–control investigation conducted between 2013 and 2015. The study enrolled 266 patients from the North Central and South West Regional Health Authorities of Trinidad. Of the 266 patients recruited, 126 were diabetic and 140 were nondiabetic.Results:Our study observed that dyslipidemia was present among the nondiabetic populations as the nondiabetics had 55 women and 20 men with high cholesterol, 22 women and 14 men with high triglyceride (TG), 30 women and 25 men with low high-density lipoprotein cholesterol (HDL-C), 42 women and 21 men with high low-density level-cholesterol (LDL-C), 13 women and 8 men with high very low-density lipoprotein (VLDL), and also 30 women and 11 men with body mass index (BMI) over 30 kg/m2. We also observed that diabetic women had significantly lower TGs (P = 0.019) and higher HDL-C (P = 0.001) and LDL (P = 0.003) when compared with the diabetic men. In addition, the nondiabetic females also had higher HDL-C (P = 0.045) when compared to their male counterparts. Both diabetic and nondiabetic women exhibited significantly higher BMI of P = 0.000. A negative correlation was obtained among TGs and HDL (r = −0.356, n = 83, P = 0.001) and a positive correlation was observed among LDL and HDL (r = 0.230, n = 86, P = 0.035).Conclusions:This study observed the incidences in the abnormalities of serum lipid profiles in both nondiabetic and diabetic persons. It also presents the high occurrence of nondiabetic women with dyslipidemia as they presented with high cholesterol, high TG, low HDL-C, and high VLD-L with BMI over 30 kg/m2.

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Section: Discussionsupporting

confidence: 78%

“…These are the prevalent characteristics of the diabetic population globally,[14] and therefore regardless of gender or ethnicity, we highly recommend that special attention should be made to this.…”

Section: Discussionmentioning

confidence: 99%

Controlling Lipids AIDS in the Prevention of Type 2 Diabetes, Hypertension, and Cardiovascular Diseases

2017

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“…Previously, several studies have explored the relationship between serum creatinine and glucose metabolism. One study with a retrospective, cross‐sectional design showed that participants with diabetes up to 50 years old had lower serum creatinine levels than those without diabetes in the same age range, while the reverse was true for those over 50 years old . The authors attributed this change to age‐related decline in renal function.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to that study, the present study had a prospective design, and subjects with potential renal damage were excluded at baseline. Moreover, we included ethnically homogeneous participants from the general population, while participants in that study were patients from clinics with different ethnicities . Therefore, when estimating the relation between creatinine and T2DM, the potential for bias would be less in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is speculated that serum creatinine may serve as a negative predictor of T2DM in the general population. Previously, the inverse correlation between serum creatinine and T2DM was observed in cross‐sectional studies conducted on Caucasian morbidly obese patients and on Trinidadian patients of ethnically heterogenous background . To date, only a brief report on a cohort with a relatively small sample size (n = 8570, including only men aged 40‐55 years) demonstrated that serum creatinine was negatively related to incident T2DM .…”

Section: Introductionmentioning

confidence: 99%

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Low serum creatinine predicts risk for type 2 diabetes

Bao

Zhang

et al. 2018

Diabetes Metabolism Res

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Elevation of serum uric acid and incidence of type 2 diabetes: A systematic review and meta‐analysis

Bai

et al. 2016

Chronic Diseases and Translational Medicine

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ObjectiveRecently, several cohort studies suggested a positive relationship between serum uric acid (SUA) and type 2 diabetes mellitus (T2DM), which is inconsistent with the results of functional research. Our aim was to further evaluate this correlation by conducting a systematic review.MethodsComputerized literature searches of the Medline database, EMBASE database, and PubMed were used to evaluate the relationship between SUA and T2DM in cohort studies. Cochran's Q and I2 statistics were used to evaluate heterogeneity among studies, and pooled relative risk (RR) and odds ratio (OR) with 95% confidence intervals (CIs) were calculated using random-effects and fixed-effects models. The summary RR and OR of per 1 mg/ml-SUA increase were calculated separately because of their different epidemiological implications and calculation methods. Additionally, sensitivity analysis, stratified analysis, meta-regression, and multiple meta-regression were applied to investigate the heterogeneity among studies.ResultsA total of 970 articles were retrieved from the searches. Sixteen publications of cohort studies containing 61,714 participants were included. The pooled RR was 1.131 (95% CI: 1.084–1.179) with significant heterogeneity among studies (I2 = 51.9%, P = 0.018). Adjusted RR to evaluate the stability of the relationship between SUA and T2DM in the sensitivity analysis was similar (RR = 1.140, 95% CI: 1.087–1.197), with statistically significant heterogeneity (I2 = 54.5%, P = 0.015). Stratified analysis and meta-regression showed that the positive relationship remained irrespective of age, sex, region, and adjustment for confounding factors including body mass index, fasting blood glucose, systolic blood pressure, diastolic blood pressure, alcohol consumption, smoking, blood cholesterol, waist circumference, fatty liver, and drugs affecting SUA.ConclusionAlthough SUA is independently associated with development of T2DM, insulin resistance increased as the baseline SUA concentration increased; thus, the correlation between SUA and T2DM requires further evaluation and the baseline insulin resistance status should also be considered.

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Association of low serum creatinine, abnormal lipid profile, gender, age and ethnicity with type 2 diabetes mellitus in Trinidad and Tobago

Cited by 17 publications

References 7 publications

Controlling Lipids AIDS in the Prevention of Type 2 Diabetes, Hypertension, and Cardiovascular Diseases

Controlling Lipids AIDS in the Prevention of Type 2 Diabetes, Hypertension, and Cardiovascular Diseases

Low serum creatinine predicts risk for type 2 diabetes

Elevation of serum uric acid and incidence of type 2 diabetes: A systematic review and meta‐analysis

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