Low serum creatinine predicts risk for type 2 diabetes

Bao, Xue; Gu, Yeqing; Zhang, Qing; Liu, Li; Meng, Guang; Wang, Hongmei; Yang, Xia; Shi, Hongbin; Wang, Honglei; Sun, Shaomei; Wang, Xing; Zhou, Ming; Jia, Qiyu; Song, Kun; Niu, Kaijun

doi:10.1002/dmrr.3011

Cited by 21 publications

(21 citation statements)

References 39 publications

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“…In the stratified analyses, we observed that the serum creatinine–diabetes association did not differ by BMI or smoking status, which is consistent with previous studies. Furthermore, we found no effect modification by chronic diseases (for example, hypertension or dyslipidemia).…”

Section: Discussionsupporting

confidence: 91%

“…The present findings are consistent with those studies using baseline creatinine only. In a 4‐year follow‐up study of Japanese male workers ( n = 8,570), the adjusted odds ratio of diabetes was 1.91 for the participants with creatinine 0.40–0.60 mg/dL compared with 0.71–0.80 mg/dL.…”

Section: Discussionsupporting

confidence: 91%

“…In a study of a general population in Japan ( n = 9,667, with a mean observation of 5 years), the adjusted HR was 1.40 for men with creatinine ≤0.7 mg/dL compared with 0.9–1.2 mg/dL, and 1.7 for women with serum creatinine ≤0.5 mg/dL compared with 0.7–1.1 mg/dL. A Chinese study of the general population ( n = 57,587, with a mean observation of 3.6 years) also showed that serum creatinine values at baseline were inversely associated with diabetes risk. The present study had a bigger sample ( n = 31,343) and longer observation period (median follow‐up period of 7.7 years) than previous studies.…”

Section: Discussionmentioning

confidence: 98%

“…Thus, it would be interesting to examine a potential association between low serum creatine and the development of diabetes. Three cohort studies from Japan and one from China reported that low serum creatinine was associated with an elevated risk (hazard ratios [HRs] ranging from 1.4 to 2.0) of diabetes. However, these cohort studies had some limitations, including short mean follow‐up periods (≤4 years), lack of adjustment for potentially important diabetes risk factors (for example, smoking and dyslipidemia) or the use of fasting glucose only for diagnosing diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Low serum creatinine and risk of diabetes: The Japan Epidemiology Collaboration on Occupational Health Study

Nakagawa

Honda

et al. 2019

J of Diabetes Invest

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Aims/Introduction We examined a prospective association between serum creatinine levels and diabetes. Materials and Methods The present study included 31,343 male workers without diabetes, and aged between 20 and 64 years at baseline. We calculated the cumulative average of their serum creatinine over the study period. We defined diabetes as either glycated hemoglobin levels ≥6.5%, random glucose levels ≥200 mg/dL, fasting glucose levels ≥126 mg/dL or receiving antidiabetic treatment. Cox proportional hazards regression analysis was carried out to estimate the hazard ratio (HR) and 95% confidence interval (CI). Results With a median observation of 7.7 years, 2,509 participants developed diabetes. After adjusting for age, smoking, body mass index, hypertension and dyslipidemia, lower cumulative average serum creatinine levels were related to a greater diabetes risk: HRs were 1.56 (95% CI 1.35–1.82), 1.22 (1.09–1.35) and 1.06 (0.96–1.17) for the participants with serum creatinine <0.70, 0.70–0.79 and 0.80–0.89 mg/dL, respectively, compared with those with 0.90–1.20 mg/dL (P for trend <0.001). The serum creatinine‐diabetes association was more pronounced among older adults (serum creatinine <0.70 vs 0.90–1.20 mg/dL, HR 1.66, 95% CI 1.37–2.00) than younger adults (HR 1.32, 95% CI 1.02–1.71; P for interaction by age group = 0.001). Conclusions Low serum creatinine is associated with an increased risk of diabetes. Screening serum creatinine levels can be used to identify those who are at high risk of diabetes.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Low serum creatinine and risk of diabetes: The Japan Epidemiology Collaboration on Occupational Health Study

Nakagawa

Honda

et al. 2019

J of Diabetes Invest

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“…Although serum Cre was not associated with incident diabetes in this study population, previous studies have shown that low Cre is associated with the presence of [40][41][42][43] or incident diabetes [44][45][46][47]. These studies showed that the risk of incident diabetes in the lowest serum Cre group was higher than that in highest serum Cre group [44][45][46][47].…”

Section: Discussioncontrasting

confidence: 74%

Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study

Hashimoto

Okamura

Obora

et al. 2020

JCM

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We investigated the association between creatinine to body weight (Cre/BW) ratio and incident diabetes. In this cohort study, 9659 men and 7417 women were follow up mean (SD) 5.6 (3.5) years and 5.4 (3.4) years, respectively. For men, tertile 1 (T1; n = 3176), Cre/BW < 0.01275; tertile 2 (T2; n = 3258), 0.01275 ≤ Cre/BW < 0.0148; and tertile 3 (T3; n = 3225), Cre/BW ≥ 0.0148; and for women, T1 (n = 2437), Cre/BMI < 0.0118; T2 (n = 2516), 0.0118 ≤ Cre/BMI < 0.014; and T3 (n = 2477), Cre/BMI ≥ 0.014. Among them, 362 men and 102 women developed diabetes. The hazard ratios (HRs) of incident diabetes in the T2 group was 0.56 (95% CI 0.44–0.71, p < 0.001) in men and 0.61 (0.38–0.99, p = 0.045) in women and in the T3 group was 0.42 (0.32–0.54, p < 0.001) in men and 0.55 (0.34–0.89, p = 0.014) in women after adjusting for covariates, compared with the T1 group. Moreover, Δ0.001 incremental of Cre/BW is negatively associated with incident diabetes (adjusted HR 0.84, 95% CI 0.80–0.88, p < 0.001 for men and 0.88, 0.81–0.96, p = 0.003 for women). In conclusion, Cre/BW ratio is inversely related to incident diabetes. Checking Cre/BW ratios may predict future diabetes risks.

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Serum creatinine levels and risk of nonalcohol fatty liver disease in a middle‐aged and older Chinese population: A cross‐sectional analysis

Niu

Zhang

et al. 2021

Diabetes Metabolism Res

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Background: Non-alcoholic fatty liver disease (NAFLD) is now regarded as the hepatic manifestation of metabolic syndrome (MetS). Recent research has suggested that serum creatinine (SCr) may be an indicator of MetS and its related diseases. We aimed to investigate the association between SCr and NAFLD in Chinese adults. Methods: A cross-sectional sample of 8862 subjects aged 40 years or older (40-73 years) from China were analysed in this study. The anthropometric measurements, laboratory tests, and hepatic ultrasonography were conducted. NAFLD presence was defined by hepatic ultrasound in the absence of other liver diseases.Results: NAFLD subjects had higher SCr than those without NAFLD (66.8 μmol/L vs. 65.6 μmol/L, p < 0.001). Moreover, SCr levels were correlated with alanine aminotransferase (β = 0.099, p < 0.001), aspartate aminotransferase (β = 0.135, p < 0.001), γ-glutamyltransferase (β = 0.039, p < 0.001), and insulin resistance (β = 0.027, p = 0.014) after adjusted for potential covariates. In the multivariableadjusted logistic regression analyses, compared to the first SCr quintile, the odds ratio for NAFLD was 1.35 (95% confidence interval 1.14-1.60, p < 0.001) for the fifth quintile after adjusting multiple measured confounders. Conclusion:SCr concentration is independently associated with NAFLD in a middle aged and older Chinese population. Elevated SCr levels, even within normal ranges, were associated with higher risk of NAFLD.

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Low serum creatinine predicts risk for type 2 diabetes

Abstract: These findings indicate that serum creatinine concentration is inversely related to incident T2DM in both men and women. Measuring serum creatinine may assist in the early detection of individuals at high risk of developing T2DM.

Cited by 21 publications

References 39 publications

Low serum creatinine and risk of diabetes: The Japan Epidemiology Collaboration on Occupational Health Study

Low serum creatinine and risk of diabetes: The Japan Epidemiology Collaboration on Occupational Health Study

Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study

Serum creatinine levels and risk of nonalcohol fatty liver disease in a middle‐aged and older Chinese population: A cross‐sectional analysis

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