Association of m.5178C>A variant with serum lipid levels: a systematic review and meta-analysis

Abstract

Background: Emerging evidence shows that m.5178C>A variant is associated with a lower risk of coronary artery disease (CAD). However, the specific mechanisms remain elusive. Since dyslipidemia is one of the most critical risk factors for CAD and accounts for at least 50% of the population-attributable risk, it is tempting to speculate that the reduced CAD risk caused by the m.5178C>A variant may stem from an improved lipid profile. In order to verify this hypothesis, we conducted this study to clarify the associations of m.5178C>A variant with lipid levels.  Methods: By searching ten databases for studies published before June 30, 2021. Thirteen East Asian populations (7,587 individuals) were included for the analysis.</p>  Results: The present study showed that m.5178C>A variant was associated with higher high-density lipoprotein cholesterol (HDL-C) [standard mean difference (SMD) = 0.12, 95% CI = 0.06—0.17, P< 0.001] and total cholesterol (TC) (SMD = 0.08, 95% CI = 0.02—0.14, P= 0.01) levels. In subgroup analysis, the association of m.5178C>A variant with higher HDL-C levels were observed in Japanese (SMD = 0.09, 95% CI = 0.01—0.17, P= 0.03) and Chinese populations (SMD = 0.13, 95% CI = 0.07—0.20, P< 0.001). However, the association of m.5178C>A variant with lower low-density lipoprotein cholesterol (LDL-C) levels were only observed in Japanese populations (SMD = -0.11, 95% CI = -0.22—-0.00, P= 0.04).</p>  Conclusions: The m.5178C>A variant was associated with higher HDL-C and lower LDL-C levels in Japanese populations, which may contribute to decreased CAD risk and longevity of Japanese.

Anthropometric and Biochemical Correlations of Insulin Resistance in a Middle-Aged Maltese Caucasian Population

“…It also has much higher heritability when compared to IR [56], implying that environmental factors that afect IR have much less impact on HDL-C. Furthermore, many of the genetic polymorphisms that have been shown to afect HDL-C concentrations would not be expected to afect insulin resistance [57][58][59][60]. It should also be noted that, although epidemiological data show that low HDL-C is associated with increased cardiovascular disease, most known genetic variants that afect HDL-C levels do not increase cardiovascular disease risk [57,61,62].…”

Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine

“…Liu F. et al [14] findings indicate that the m.5178C > A variant is linked to elevated levels of high-density lipoprotein cholesterol (HDL-C), standardized mean difference (SMD) = 0.12, 95%, confidence interval (CI) = 0.06-0.17, p < 0.001], and total cholesterol (TC) (SMD = 0.08, 95% CI = 0.02-0.14, p = 0.01). When we examined specific populations, we found that the m.5178C > A variant was associated with increased HDL-C levels in both Japanese (SMD = 0.09, 95% CI = 0.01-0.17, p = 0.03) and Chinese (SMD = 0.13, 95% CI = 0.07-0.20, p < 0.001) groups.…”