2023
DOI: 10.3390/biomedicines11102864
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Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine

Marcello Bergonzini,
Francesco Loreni,
Antonio Lio
et al.

Abstract: Epigenetic modifications play a fundamental role in the progression of coronary artery disease (CAD). This panoramic review aims to provide an overview of the current understanding of the epigenetic mechanisms involved in CAD pathogenesis and highlights the potential implications for personalized medicine approaches. Epigenetics is the study of heritable changes that do not influence alterations in the DNA sequence of the genome. It has been shown that epigenetic processes, including DNA/histone methylation, a… Show more

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Cited by 4 publications
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“…Recognizing the synergistic effects of hypertension, epigenetic modifications, and T2DM on CAD development is crucial for effective risk assessment and management strategies ( 143 ). Clinicians should consider these factors when evaluating cardiovascular risk in patients with T2DM.…”
Section: Discussionmentioning
confidence: 99%
“…Recognizing the synergistic effects of hypertension, epigenetic modifications, and T2DM on CAD development is crucial for effective risk assessment and management strategies ( 143 ). Clinicians should consider these factors when evaluating cardiovascular risk in patients with T2DM.…”
Section: Discussionmentioning
confidence: 99%