Association of markers of endothelial dysfunction with depression in middle-aged patients with cerebral microangiopathy

Vorobieva, O. V.; Fateeva, V V

doi:10.17116/jnevro20211210417

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…В исследованиях ряда авторов была показана значимая роль именно комплексного определения перечисленных биомаркёров, в частности: адипонектина, NO, АДМА, PAI-1 и t-PA. Проатерогенный сдвиг в активности всех указанных биологических молекул отмечен у «асимптомных» пациентов с выраженным церебральным атеросклерозом [34,54,55]. Следовательно, комплексная оценка биохимических параметров позволяет выявить атеросклероз на ранних стадиях, когда нет ещё клинической картины.…”

Section: особенности нарушений метаболизма у пациентов с бессимптомны...unclassified

Pathophysiological aspects of the development of cerebral atherosclerosis

Гусейнова¹,

Соловьева²,

Тихонова³

et al. 2022

Nauchno-Prakticheskii Zhurnal «Patogenez»

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Сосудистые заболевания головного мозга на сегодняшний день являются важнейшей медико-социальной проблемой. Одним из ведущих факторов развития данной патологии является атеросклеротическое поражение церебральных сосудов. Обзор посвящен патогенетической значимости биохимических маркёров при церебральном атеросклерозе. Рассмотрены современные данные о механизмах, лежащих в основе атеросклеротического поражения сосудов. Показано участие эндотелиальной дисфункции, окислительного стресса, воспаления и нарушений липидного обмена в патогенезе атеросклероза. Отмечена роль таких биохимических маркёров, как эндотелин-1, оксид азота, адипонектин, интерлейкин-6, интерлейкин-1β, С-реактивный белок, фактор некроза опухоли-альфа в развитии атеросклероза и показана их взаимосвязь с клиническими проявлениями церебрального атеросклероза. Cerebrovascular disease is the most important current medical and social challenge. Cerebral atherosclerosis is one of the leading factors in the development of this pathology. This review focuses on the pathogenetic significance of biochemical markers for cerebral atherosclerosis. The modern view of the mechanisms underlying atherosclerotic lesions is addressed in detail. The review shows the involvement of endothelial dysfunction, oxidative stress, and lipid metabolic disorders in the pathogenesis of atherosclerosis. The authors highlighted the role of biochemical markers, such as endothelin-1, nitric oxide, adiponectin, interleukin-6, interleukin-1ß, C-reactive protein, and tumor necrosis factor-alpha, in the development of atherosclerosis and underlined their relationship with clinical manifestations of cerebral atherosclerosis.

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Section: особенности нарушений метаболизма у пациентов с бессимптомны...unclassified

Pathophysiological aspects of the development of cerebral atherosclerosis

Гусейнова¹,

Соловьева²,

Тихонова³

et al. 2022

Nauchno-Prakticheskii Zhurnal «Patogenez»

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Cognitive impairment in COVID-19 patients complicated by depression after the acute phase

Vorob’еva,

Shindryaeva,

Fateeva

2024

Neurology bulletin

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BACKGROUND: Damage of the central nervous system in COVID-19 patients includes cognitive impairment, depression, and fatigue. Clinical features of cognitive impairment after the acute phase of COVID-19 and the contribution of various factors to the development of memory deficit have not been fully studied. AIM: This study assesses the clinical features of cognitive impairment in COVID-19 patients complicated by depression after the acute phase and analyzes how health and demographic factors contribute to the development of cognitive impairment. MATERIALS AND METHODS: The observational cross-sectional study includes 33 patients aged 18–80 (mean age: 53.5; women: 60.6%) who meet the eligibility criteria. All subjects had a clinical semi-structured interview, a general clinical examination, MoCA, HDRS-17, and MFI-20 neuropsychological tests. RESULTS: The average MoCA-total score was 23.8±2.2. Cognitive impairments primarily affected memory (average MoCA memory score: 10.5±2.0), executive functions (average MoCA executive functioning score: 9.5±1.1), and attention (average MoCA attention score: 14.8±1.9). There is a strong negative correlation of HDRS-17 and MoCA-total values ( r=−0.72; p0.05), executive functioning index ( r=−0.82; p0.05), and memory index ( r=−0.85; p0.05). Age (β=−0.028; p=0.03), number of cardiovascular risk factors (β=−0.53; p=0.001), severity of COVID-19 in the acute phase (β=−0.97; p=0.001) and depression (β=−0.065; p=0.02) are the main contributors to cognitive impairment. CONCLUSION: Multi-domain cognitive impairment with predominant deterioration of executive functions, memory and attention was detected in patients who had COVID-19 complicated by depression after the acute phase. The key factors of, or main contributors to, cognitive impairment were identified, which can help select the best targeted therapy for this category of patients.

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Association of markers of endothelial dysfunction with depression in middle-aged patients with cerebral microangiopathy

Cited by 2 publications

References 12 publications

Pathophysiological aspects of the development of cerebral atherosclerosis

Pathophysiological aspects of the development of cerebral atherosclerosis

Cognitive impairment in COVID-19 patients complicated by depression after the acute phase

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