Association of Maternal Iodine Status With Child IQ: A Meta-Analysis of Individual Participant Data

Levie, Deborah; Korevaar, Tim I M; Bath, Sarah C.; Murcia, Mario; Dineva, Mariana; Llop, Sabrina; Espada, Mercedes; Herwaarden, Antonius E. van; Rijke, Yolanda B. de; Ibarluzea, Jesús; Sunyer, Jordi; Tiemeier, Henning; Rayman, Margaret P.; Guxens, Mònica; Peeters, Robin P.

doi:10.1210/jc.2018-02559

Cited by 105 publications

(84 citation statements)

References 51 publications

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“…Moreover, the introduction of iodine prophylaxis overcame that difference in children born afterwards (5) . Even mild to moderate iodine deficiency in pregnancy may impact the verbal IQ of children, as it was recently demonstrated in a meta-analysis of results of three prospective European birth cohorts (Generation R, INMA, ALSPAC) (6) . Adequate iodine nutrition during the first 1000 days of life (including fetal period, infancy and early childhood) is of utmost importance, as during that period a child is almost exclusively dependent on iodine and thyroid hormones supply from his or her mother (7) .…”

mentioning

confidence: 82%

Current iodine nutrition status in Poland (2017): is the Polish model of obligatory iodine prophylaxis able to eliminate iodine deficiency in the population?

Trofimiuk–Müldner

Konopka

Sokołowski

et al. 2020

Public Health Nutr.

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Objective: The monitoring of the populations’ iodine status is an essential part of successful programmes of iodine deficiency elimination. The current study aimed at the evaluation of current iodine nutrition in school children, pregnant and lactating women as a marker of the effectiveness and sustainability of mandatory iodine prophylaxis in Poland. Design: The following iodine nutrition indicators were used: urinary iodine concentration (UIC) (all participants) and serum thyroglobulin (pregnant and lactating women). Setting: The study was conducted in 2017 within the National Health Programme in five regions of Poland. Participants: The research included 300 pregnant women, 100 lactating women and 1000 school children (aged 6–12 years). Results: In pregnant women, median UIC was 111·6 µg/l; there was no significant difference in median UIC according to the region of residence. In 8 % of pregnant women, thyroglobulin level was >40 ng/ml (median thyroglobulin 13·3 ng/ml). In lactating women, median UIC was 68·0 µg/l. A significant inter-regional difference was noted (P = 0·0143). In 18 % of breastfeeding women, thyroglobulin level was >40 ng/ml (median thyroglobulin 18·5 ng/ml). According to the WHO criteria, the investigated sample of pregnant and lactating women was iodine-deficient. Median UIC in school children was 119·8 µg/l (with significant inter-regional variation; P = 0·0000), which is consistent with iodine sufficiency. Ninety-four children (9·4 %) had UIC < 50 µg/l. Conclusions: Mandatory iodisation of household salt in Poland has led to a sustainable optimisation of iodine status in the general population. However, it has failed to assure adequate iodine nutrition during pregnancy and lactation.

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mentioning

confidence: 82%

Current iodine nutrition status in Poland (2017): is the Polish model of obligatory iodine prophylaxis able to eliminate iodine deficiency in the population?

Trofimiuk–Müldner

Konopka

Sokołowski

et al. 2020

Public Health Nutr.

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“…Using the one-step approach, we observed a positive curvilinear association between UI/Creat and verbal IQ score [ Fig. 3(a) and (30)]. There was a positive linear association when measures in preschool children from Generation R were excluded.…”

Section: Verbal Iqmentioning

confidence: 98%

“…Urinary creatinine concentration was determined by the Jaffe rate method in all cohorts. More information on the measurement methods and the variability between assays can be found in an online repository (30).…”

Section: Maternal Iodine Statusmentioning

confidence: 99%

“…Using pooled data in the one-step approach, we observed a positive linear association between the UI/Creat and mean nonverbal IQ score [ Fig. 2(a) and (30)], although this association was not statistically significant. Using the two-step approach in which we combined cohortspecific effect estimates using random-effects meta-analysis, neither UI/Creat ,150 mg/g nor UI/Creat $500 mg/g was associated with nonverbal IQ score (20.…”

Section: Nonverbal Iqmentioning

confidence: 99%

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Association of maternal iodine status with child IQ: a meta-analysis of individual-participant data

Levie¹,

Tim²,

Bath³

et al. 2019

ESPE

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ORCiD numbers: 0000-0002-9164-4869 (D. Levie). Context: Although the consequences of severe iodine deficiency are beyond doubt, the effects of mild to moderate iodine deficiency in pregnancy on child neurodevelopment are less well established. Objective: To study the association between maternal iodine status during pregnancy and child IQ and identify vulnerable time windows of exposure to suboptimal iodine availability.

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“…Inadequate iodine intake during pregnancy has long been known to be associated with gestational goitrogenesis in the mother (43) and with impaired fetal brain development (44). More recently, it became clear that the increased iodine requirement does not end with delivery, but rather it persists in lactating women.…”

Section: Iodine Supplementation In Pp Periodmentioning

confidence: 99%

Graves' Disease and the Post-partum Period: An Intriguing Relationship

et al. 2019

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The post-partum period is an immunologically peculiar period in a woman's life. Indeed, most of the pregnancy-related immune changes gradually revert in the 12 months following delivery. Although the post-partum period has long been identified as a period of aggravation of autoimmune thyroid diseases, most of the currently available studies took into account the relationship between post-partum and autoimmune thyroiditis. More recently, the potential repercussions of the post-partum period on Graves' disease were also taken into account. The present mini review will briefly overview the most recent advances in our knowledge of the immunology of the post-partum period in relation with the potential repercussions on the clinical course of Graves' disease. Moreover, some peculiar aspects of post-partum Graves' disease in terms of clinical and biochemical presentation, diagnostic challenges, and specific therapeutic considerations also taking into account the recommendation of the latest clinical guidelines on the management of thyroid diseases in pregnancy will be overviewed.

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Association of Maternal Iodine Status With Child IQ: A Meta-Analysis of Individual Participant Data

Cited by 105 publications

References 51 publications

Current iodine nutrition status in Poland (2017): is the Polish model of obligatory iodine prophylaxis able to eliminate iodine deficiency in the population?

Current iodine nutrition status in Poland (2017): is the Polish model of obligatory iodine prophylaxis able to eliminate iodine deficiency in the population?

Association of maternal iodine status with child IQ: a meta-analysis of individual-participant data

Graves' Disease and the Post-partum Period: An Intriguing Relationship

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