Association of MBL2 exon1 polymorphisms with high-risk human papillomavirus infection and cervical cancers: a meta-analysis

Wang, Hui-Lian; Lu, Xi; Yang, Xudong; Xu, Nan

doi:10.1007/s00404-016-4201-z

Cited by 13 publications

(7 citation statements)

References 32 publications

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“…Through a meta-analysis of existing data on CC, a recent study demonstrated that MspI and Ile462Val polymorphisms in CYP1A1 gene are potential risk factors for CC development [56]. Another study suggested a potential association between MBL2 gene exon1 polymorphisms and an increased risk of CC development [57]. Interestingly, studies of various populations in African countries, including South Africa, Zimbabwe, Morocco, Sudan, Tunisia, and Senegal, identified an association between CC risk and polymorphisms in TGFBT10C , TGFBc509T , HLADRB1 , CCR2V6L , IL-10-1082G / A , and FasR-1377G genes [20].…”

Section: Introductionmentioning

confidence: 99%

Human Papilloma Virus-Associated Cervical Cancer and Health Disparities

Olusola

Banerjee

Philley

et al. 2019

Cells

264

156

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Cervical cancer develops through persistent infection with high-risk human papilloma virus (hrHPV) and is a leading cause of death among women worldwide and in the United States. Periodic surveillance through hrHPV and Pap smear-based testing has remarkably reduced cervical cancer incidence worldwide and in the USA. However, considerable discordance in the occurrence and outcome of cervical cancer in various populations exists. Lack of adequate health insurance appears to act as a major socioeconomic burden for obtaining cervical cancer preventive screening in a timely manner, which results in disparate cervical cancer incidence. On the other hand, cervical cancer is aggressive and often detected in advanced stages, including African American and Hispanic/Latina women. In this context, our knowledge of the underlying molecular mechanism and genetic basis behind the disparate cervical cancer outcome is limited. In this review, we shed light on our current understanding and knowledge of racially disparate outcomes in cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Human Papilloma Virus-Associated Cervical Cancer and Health Disparities

Olusola

Banerjee

Philley

et al. 2019

Cells

264

156

View full text Add to dashboard Cite

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“…Cervical cancer is one of the most common gynecological malignancies worldwide with an estimated 570,000 cases and 311,000 deaths in 2018 1. The causal role of high-risk human papillomavirus (HR-HPV) in cervical intraepithelial neoplasia (CIN) has been approved by various studies 2, 3. Especially, HPV16 is by far the most common type of carcinogenic globally, with the positivity rate of over 60% in cervical cancer patients 4.…”

Section: Introductionmentioning

confidence: 99%

Association between Vaginal Micro-environment Disorder and Cervical Intraepithelial Neoplasia in a Community Based Population in China

Li¹,

Ding²,

Gao³

et al. 2020

J. Cancer

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There are other factors that contribute to cervical carcinogenesis except HPV infection. This study aimed to investigate the association between vaginal micro-environment factors, including H 2 O 2 , vaginal PH value, vagina cleanness, β-glucuronidase, coagulase, neuraminidase and leukocyte esterase and cervical intraeipithelial neoplasia (CIN). In total 1019 participants, including 623 normal cervical (NC) women, 303 patients with low-grade cervical intraepithelial neoplasia (CIN1) and 93 patients with high-grade cervical intraepithelial neoplasia (CIN2/3), were enrolled into the study. HPV genotyping was detected by flow-through hybridization and gene chip. Vaginal H 2 O 2 , β-glucuronidase, coagulase, neuraminidase and leukocyte esterase were detected by Aerobic Vaginitis (AV) / Bacterial Vaginal Disease (BV) Five Joint Test Kit. Vaginal PH was measured on the glass slide after microscopy, using color strips with a PH range of 3.8-5.4. Vagina cleanness was determined according to the National Clinical Laboratory Practice Guideline. χ 2 test and Logistic regression were operated using SPSS 22.0 software. Our results showed that HPV16 infection rate and the abnormal rates of H 2 O 2 , PH, vagina cleanness, β-glucuronidase or neuraminidase increased gradually along with the severity of CIN (P<0.05). Abnormities of H 2 O 2 , cleanness, β-glucuronidase and neuraminidase were risk factors for CIN regardless of HPV16 infection, furthermore, abnormities of PH value, leukocyte esterase could also increase the risk of CIN in HPV16 positive group. In addition, women with abnormal vaginal micro-environment factors in HPV16 positive group had a significantly higher risk of developing CIN than HPV16 negative group. The results from generalized multifactor dimensionality reduction (GMDR) model showed that there was interaction effect with abnormities of vagina cleanness, H 2 O 2 , β-glucuronidase and neuraminidase on CIN2/3 in HPV16 negative group, while, there was interaction effect with abnormities of vagina cleanness, β-glucuronidase and neuraminidase on CIN1 and with abnormities of vagina cleanness, PH, H 2 O 2 , β-glucuronidase, neuraminidase and leukocyte esterase on CIN2/3 in HPV16 positive group. Our results suggested that vaginal micro-environment disorder could increase the risk of CIN, especially, the abnormality of H 2 O 2 , cleanness, β-glucuronidase and neuraminidase. There were interaction effects with abnormities of H 2 O 2 , vagina cleanness, β-glucuronidase and neuraminidase on CIN whether HPV16 was infected or not.

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“…Virtually, all cases of CC result from infection with the oncogenic strains of human papillomavirus (HPV) [ 3 , 4 ]. The majority of HPV infections are short-lived and resolve spontaneously [ 5 – 7 ]. However, in some individual cases, permanent infection will lead to development of a precancerous lesion, known as cervical intraepithelial neoplasia or adenocarcinoma in situ [ 5 ] Additional factors increasing the likelihood of the development of CC include tobacco smoking, long-term oral contraceptive use, high parity, early sexual intercourse, pollutants, and co-infection with type 2 herpes simplex virus or the human immunodeficiency virus [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

The association of CCAT2 rs6983267 SNP with MYC expression and progression of uterine cervical cancer in the Polish population

Łaźniak

Lutkowska

Wareńczak-Florczak

et al. 2018

Arch Gynecol Obstet

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PurposePrevious studies have reported a significant contribution of NC_000008.10:g.128413305 G>T (rs6983267) single-nucleotide polymorphism (SNP) in the MYC enhancer region to the susceptibility of various cancers. However, the role of rs6983267 SNP in cervical cancer (CC) development and progression has not been demonstrated to date. Therefore, we evaluated the role of rs6983267 SNP in MYC expression in cervical cancers and non-cancerous cervical tissues. In addition, we assessed the role of this SNP in the development and progression of CC.MethodsUsing high-resolution melting analysis, we evaluated rs6983267 SNP frequency in women diagnosed with cervical squamous cell carcinoma (SCC) (n = 481) and controls (n = 502) in a Polish Caucasian population. Logistic regression analysis was employed to adjust for the effects of age, parity, oral contraceptive use, tobacco smoking, and menopausal status.ResultsDividing patients based on clinical characteristics demonstrated an association of the rs6983267 genotype with tumor stage III and grade of differentiation G2 and G3. The p trend value calculated for the rs6983267 SNP in patients with stage III was 0.0006. We also observed a significant contribution of rs6983267 SNP to tumor grade of differentiation G2 and G3. Additional contributors were oral contraceptive use, smoking, and postmenopausal age. We found statistically significant increase of MYC transcript levels in cervical SCC tissues from carriers of the GG vs. T/T (p < 0.00001), G/T vs. T/T (p = 0.0002), and in the non-cancerous cervical tissues from carriers of the GG vs. T/T (p = 0.00046).ConclusionThe rs6983267 SNP may contribute to the increased MYC expression as well as the spread and rapid growth of cervical SCC as compared to lower grade carcinomas.Electronic supplementary materialThe online version of this article (10.1007/s00404-018-4740-6) contains supplementary material, which is available to authorized users.

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Association of MBL2 exon1 polymorphisms with high-risk human papillomavirus infection and cervical cancers: a meta-analysis

Cited by 13 publications

References 32 publications

Human Papilloma Virus-Associated Cervical Cancer and Health Disparities

Human Papilloma Virus-Associated Cervical Cancer and Health Disparities

Association between Vaginal Micro-environment Disorder and Cervical Intraepithelial Neoplasia in a Community Based Population in China

The association of CCAT2 rs6983267 SNP with MYC expression and progression of uterine cervical cancer in the Polish population

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