Association of Mean Daily Polyphenols Intake with Mediterranean Diet Adherence and Anthropometric Indices in Healthy Greek Adults: A Retrospective Study

Kapolou, Aikaterini; Karantonis, Haralabos C.; Rigopoulos, Nikolaos; Koutelidakis, Antonios E.

doi:10.3390/app11104664

Cited by 16 publications

(8 citation statements)

References 50 publications

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“…Regular dietary intake of polyphenols, approximately 1–2 g per day, has been associated with chronic disease prevention [ 52 ]. Although there is no official recommendation for phenolic compounds, it is worth noting that a serving of 50 g of BQC (40% substitution) could provide almost 25% of the reported mean daily intake (1 and 1.2 g/d) [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Improving Nutritional and Health Benefits of Biscuits by Optimizing Formulations Based on Sprouted Pseudocereal Grains

Paucar-Menacho

López

Martínez

et al. 2022

Foods

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A mixture design (MD) was used to evaluate the effect of replacing wheat flour (WF) with sprouted cañihua (Chenopodium pallidicaule Aellen), kiwicha (Amarathus caudatus L.), and quinoa (Chenopodium quinoa Willd.) flours (SCF, SKF, and SQF, respectively) on the content of phytic acid (PA), γ-aminobutyric acid (GABA), total soluble phenolic compounds (TSPC), and antioxidant activity (AA) in biscuits. Generally, sprouted pseudocereal flours contained lower amounts of starch and protein, comparable fat, ash, PA content, and increased levels of bioactive compounds (GABA and TSPC) and AA compared with wholegrain flours. Moreover, it was confirmed that sprouted pseudocereal flours were nutritionally superior to refined WF. MD allowed the modeling of target parameters showing that PA, GABA, TSPC, and AA were positively influenced by the proportion of flours in the biscuit. The models that better described the variation in nutritional parameters as a function of the formulation displayed typically linear and binary interactions terms. SKF exerted the highest influence on the increased content of PA. Therefore, to increase mineral bioavailability, the use of SCF and SQF in the formulation of biscuits was suggested. SCF and SQF positively influenced in GABA, TSPC, and AA in biscuits. The optimal ternary blends of flours that maximize the content of bioactive compounds and AA of biscuits and simultaneously minimize PA content were identified. To study the fate of biscuits in digestion, the optimal formulation for biscuits containing SQF/SCF was selected. For this type of baked product, reduced starch digestibility and glycemic index was observed compared with the control (100% WF). Moreover, the amounts of bioaccessible GABA, TSPC, and AA were higher in gastric and intestinal digests compared with control biscuit. Overall, these results highlighted the nutritional and health benefits of incorporation of flours from sprouted Andean grains in the production of biscuits.

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Section: Resultsmentioning

confidence: 99%

Improving Nutritional and Health Benefits of Biscuits by Optimizing Formulations Based on Sprouted Pseudocereal Grains

Paucar-Menacho

López

Martínez

et al. 2022

Foods

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“…Although there are no data regarding the amount of phenolic compounds needed to be ingested to have an healthy diet, the World Health Organization and Food and Agriculture Organization of the United Nations (WHO/FAO) report recommends a population-wide intake goal of 400 g of edible fruit and vegetables per day for the prevention of non-communicable diseases [59]. This amount of fruit and vegetables corresponds to a regular dietary intake of polyphenols of approximately 1-2 g per day [60].…”

Section: Phytochemical Compounds: Structure Food Sources Bioavailabil...mentioning

confidence: 99%

The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention

et al. 2022

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Research in pharmacological therapy has led to the availability of many antidiabetic agents. New recommendations for precision medicine and particularly precision nutrition may greatly contribute to the control and especially to the prevention of diabetes. This scenario greatly encourages the search for novel non-pharmaceutical molecules. In line with this, the daily and long-term consumption of diets rich in phenolic compounds, together with a healthy lifestyle, may have a protective role against the development of type 2 diabetes. In the framework of the described studies, there is clear evidence that the bio accessibility, bioavailability, and the gut microbiota are indeed affected by: the way phenolic compounds are consumed (acutely or chronically; as pure compounds, extracts, or in-side a whole meal) and the amount and the type of phenolic compounds (ex-tractable or non-extractable/macromolecular antioxidants, including non-bioavailable polyphenols and plant matrix complexed structures). In this review, we report possible effects of important, commonly consumed, phenolic-based nutraceuticals in pre-clinical and clinical diabetes studies. We highlight their mechanisms of action and their potential effects in health promotion. Translation of this nutraceutical-based approach still requires more and larger clinical trials for better elucidation of the mechanism of action toward clinical applications.

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“…In particular, stratifying the adolescents into three groups based on their polyphenol intake (low, moderate, and high), KIDMED score revealed an optimal adherence to the MD (8:21 ± 1:84) in high polyphenols' consumers, suggesting that the health benefits of the MD could be related to the high intake of fruits and vegetables. Other authors have reported a linear correlation between MD and the intake of polyphenols [42,50]. Nowadays, the MD is considered one of the healthiest eating patterns, due to high consumption of fruits and vegetables, which represent the main food sources of polyphenols, along with a high intake of legumes, nuts and whole grains, low-fat dairy, a moderate intake of fish, and reduced consumption of meat [54], thus providing a balanced intake of macro-and micronutrients.…”

Section: Discussionmentioning

confidence: 98%

“…Phenol-Explorer is an updated comprehensive database for natural polyphenols including food synthesis, processing, and humans' polyphenol metabolites (http://phenol-explorer.eu-version3.6). The last version of Phenol-Explorer database provides data on 502 polyphenol compounds in 452 plant-based foods collected from 638 scientific peer-reviewed articles and divided in the main polyphenol classes [42][43][44]. The Phenol-Explorer 3.6 database reports data that also consider the effects of cooking and food processing on polyphenol content.…”

Section: Adherence To Thementioning

confidence: 99%

Serum from Adolescents with High Polyphenol Intake Exhibits Improved Lipid Profile and Prevents Lipid Accumulation in HepG2 Human Liver Cells

Augimeri

Avolio

Caparello

et al. 2023

Oxidative Medicine and Cellular Longevity

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The traditional Mediterranean diet (MD) is characterized by a high phenolic-rich food intake, including in particular vegetables and fruits, but also legumes, whole grain cereals, nuts, and extra virgin olive oil. Evidence for beneficial effects of polyphenols in humans depends on the amount consumed and on their bioavailability. Here, we evaluated the association between the estimated polyphenol intake by fruits and vegetables food source and serum biochemical parameters in healthy adolescents, recruited into the DIMENU research project. Categorizing adolescents into three groups according to their estimated total polyphenol intake, we found that adolescents who declared high consumption of polyphenols had a higher adherence to the MD and had a better serum lipid profile than adolescents consuming low amounts of polyphenols. Moreover, using human HepG2 liver cells treated with oleic acid as an in vitro model for studying lipid accumulation, we showed that intracellular lipid accumulation is alleviated by serum from adolescents consuming a polyphenol-rich diet following MD recommendations. Our data underline the importance of promoting adherence to the typical MD foods as a superior strategy to prevent metabolic and chronic diseases and to ensure a better quality of life among adolescents.

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Association of Mean Daily Polyphenols Intake with Mediterranean Diet Adherence and Anthropometric Indices in Healthy Greek Adults: A Retrospective Study

Cited by 16 publications

References 50 publications

Improving Nutritional and Health Benefits of Biscuits by Optimizing Formulations Based on Sprouted Pseudocereal Grains

Improving Nutritional and Health Benefits of Biscuits by Optimizing Formulations Based on Sprouted Pseudocereal Grains

The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention

Serum from Adolescents with High Polyphenol Intake Exhibits Improved Lipid Profile and Prevents Lipid Accumulation in HepG2 Human Liver Cells

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