2007
DOI: 10.1016/j.cca.2007.01.012
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Association of metabolic syndrome and hepatitis B infection in a Chinese population

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Cited by 42 publications
(50 citation statements)
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“…The current study is also in keeping with data from Taiwan and China indicating that HBV-infected patients have reduced triglyceride level and a lower prevalence of metabolic syndrome overall [26,27]. The observation is consistent across these large population studies and unlikely to be due to chance.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…The current study is also in keeping with data from Taiwan and China indicating that HBV-infected patients have reduced triglyceride level and a lower prevalence of metabolic syndrome overall [26,27]. The observation is consistent across these large population studies and unlikely to be due to chance.…”
Section: Discussionsupporting
confidence: 91%
“…In transgenic mouse and cell line models, hepatitis B X (HBx) protein expression results in hepatic steatosis and activation of the nuclear factor kappaB pathway [24,25]. On the other hand, two studies on ethnic Chinese population failed to demonstrate a positive correlation between hepatitis B infection and metabolic syndrome [26,27]. The association with fatty liver has also not been adequately tested in large human studies.…”
Section: Introductionmentioning
confidence: 95%
“…The results from Table 2 is consistent with the reported works of Ianello et al (2003) and Luo et al (2007) who showed an inverse correlation between HBV-infection and elevated serum triglyceride levels even though their studies were carried out in different geographical locations and settings. Upon infection, the viral X protein (HBxP) interacts with host hepatic metabolic genes such as sterol regulator element binding protein-1 (SREBP-1), carbohydrate regulator element binding protein (ChREBP), peroxisome proliferator activator receptor-gamma (PPAR-γ), among others.…”
Section: Discussionsupporting
confidence: 83%
“…According to one early study from Shanghai, the prevalence of NAFLD in participants who were seropositive for hepatitis B surface antigen (HBsAg) was even less than HBsAg-negative counterparts (8% vs. 15%) [26,64]. This could partly be due to an inverse relationship between the presence of MetS and serum HBsAg-positive status in Chinese people [65,66]. Therefore, persons with chronic HBV infection are not a highrisk population for NAFLD.…”
Section: Nafld and Chronic Viral Hepatitis In Chinamentioning
confidence: 94%