Association of metabolic syndrome and its components with suicidal ideation and depression in adults: A nationally representative sample of the Korean population

Ko, Jeong Kyung; Han, Kook Nam; Shin, Cheolmin; Lee, Seung-Hoon; Kim, Yong Ku; Yoon, Ho Kyong; Ko, Young Hwii

doi:10.1016/j.jad.2019.02.049

Cited by 12 publications

(9 citation statements)

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“…Batty et al conducted a 14-year follow up study and found that increased fasting blood glucose increased the risk of suicide [ 21 ]. Further, Ko et al reported that elevated levels of fasting plasma glucose may lead to suicidal risk [ 31 ]. Glucose is a ubiquitous source of energy and provides energy to human brain cells.…”

Section: Discussionmentioning

confidence: 99%

Potential metabolic monitoring indicators of suicide attempts in first episode and drug naive young patients with major depressive disorder: a cross-sectional study

et al. 2020

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Backgrounds: Major depressive disorder is an ordinary mental disorder, and suicide is considered to be a major concern among patients with MDD. Previous studies focused on the relationship between suicide attempts and metabolism in elderly patients with MDD, while ignore the young people. The aim of this study is to find the potential relationship between suicide attempts and metabolism in young patients with MDD to find a way to prevent and ultimately reduce suicide in young patients with MDD. Methods: Cross-sectional design was employed in the study.740 patients aged between 18 and 45 years old with MDD had been consecutively recruited in this study between 2011 and 2017, 128 of whom had suicide attempts. Their serum samples used to monitor fasting blood glucose, serum lipids as well as socio-demographic characteristics were collected. Besides, some clinical scales were also employed to measure symptoms of anxiety, depression and other conditions. Results: This study indicated that compared with non-suicide attempters, suicide attempters in young patients with MDD showed higher levels of FBG, TC, LDL-C (all p < 0.05) and lower levels of HDL-C(p < 0.001). Further logistic regression analysis suggested that suicide attempts were associated with increased FBG, decreased HDL-C, the course of disease, HAMD scores and obvious anxiety. Conclusions: Suicide attempts in young patients with MDD may be predicted by metabolic levels in the future. And our findings suggested that the level of FBG and HDL-C can be promising biomarkers to predict the occurrence of this event.

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Section: Discussionmentioning

confidence: 99%

Potential metabolic monitoring indicators of suicide attempts in first episode and drug naive young patients with major depressive disorder: a cross-sectional study

et al. 2020

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“…The total sample sizes of the cross-sectional and cohort studies were 111,866 and 287, 628, respectively. Most of cross-sectional studies (4 studies in each country) had been conducted in Brazil [3,[20][21][22] and South Korea [23][24][25][26]; and most cohort studies (n = 6) had been conducted in America [7,[27][28][29][30][31].…”

Section: Study and Participants' Characteristicsmentioning

confidence: 99%

The relationship between depression and risk of metabolic syndrome: a meta‐analysis of observational studies

Moradi

Albatineh

Mahmoodi

et al. 2021

Clin Diabetes Endocrinol

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Introduction The link between metabolic syndrome and depression has always been controversial. Different studies that have examined the relationship between metabolic syndrome and depression have reported different results. Therefore, the goal of the present study was to examine the association between depression and MetS by meta-analysis. Methods Embase, Scopus, PubMed, and ISI were searched for publications in English from January 1990 to February 2020. Search included cohort and cross-sectional studies aimed at examining the association between depression and MetS. The risk of bias was assessed by Newcastle-Ottawa Scale. Heterogeneity and publication bias were tested, subgroup analysis and meta-regression were conducted. Results 49 studies with total sample size 399,494 were analyzed. Results indicated the odds of MetS was higher in depressed compared to non-depressed individuals [OR: 1.48; 95 %CI: 1.33–1.64) vs. (OR: 1.38; 95 %CI: 1.17–1.64)]. For cross-sectional studies, depressed patients in Europe (OR = 1.35; 95 %CI: 1.47–1.99) were at higher odds of MetS compared to those in America and Asia. For cohort studies, depressed patients in America (OR = 1.46; 95 %CI: 1.16–1.84) were at higher odds of MetS than those in Europe. Cross-sectional studies indicated women with depression were at higher odds of MetS (OR = 1.95; 95 %CI: 1.38–2.74) compared to men. In both types of studies, the odds of MetS decreased with age. Conclusions Metabolic syndrome is more common in depressed compared to non-depressed individuals.

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“…There are available sources indicated that both biological and environmental factors impact on the aetiology of suicidal ideation in patients with MDD. Some studies approved that the aetiology of suicidal ideation is related to gene expression including involvement of the brain-derived neurotrophic factor-neurotrophic receptor tyrosine kinase-cAMP responsive element binding protein pathway (Pulay & Rethelyi, 2016;Bozorgmehr et al, 2018), the level of heterotrimeric G proteins (Gonzalez-Maeso & Meana, 2006), low central nervous system serotonin level (van Heeringen, 2003), and high triglyceride level and elevated fasting plasma glucose level (Ko et al, 2019). In addition, recent epidemiological investigation also showed that environment factors may be at work in the aetiology of suicidal ideation such as unhealthy family environment, low standard of living, and stressful life events in the preceding 12 months (Dutta et al, 2017).…”

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confidence: 99%

Dorsolateral and ventrolateral prefrontal cortex structural changes relative to suicidal ideation in patients with depression

Zhang

Wei

Chang

et al. 2020

Acta Neuropsychiatr.

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The prefrontal cortex (PFC) is enormously important in suicide and major depressive disorder (MDD). However, little is known about the structural alterations in the brains of people with MDD and suicidal ideation. We examined the gray matter volume (GMV) of the PFC of individuals with MDD and suicidal ideation to determine if PFC volumetric differences contribute to suicidal ideation in patients with MDD. Thirty-five subjects with MDD and suicidal ideation, 38 subjects with MDD but without suicidal ideation, and 43 age- and gender-matched healthy control (HC) subjects underwent T1-weighted imaging. A voxel-based morphometric analysis was conducted to compare the PFC GMVs of the three groups. Further GMV reductions in the left and right dorsolateral PFC (DLPFC) and right ventrolateral PFC (VLPFC) were detected in the MDD with suicidal ideation group compared with those in the HC group and the MDD without suicidal ideation group, whereas the MDD without suicidal ideation group only exhibited significant differences in the left DLPFC relative to the HC group. Our findings demonstrated that left DLPFC reductions were associated with MDD and suicidal ideation, and diminished GMV reductions in the right DLPFC and right VLPFC were only associated with suicidal ideation. These results help us better understand the neuropathological changes in MDD with suicidal ideation.

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Association of metabolic syndrome and its components with suicidal ideation and depression in adults: A nationally representative sample of the Korean population

Cited by 12 publications

References 53 publications

Potential metabolic monitoring indicators of suicide attempts in first episode and drug naive young patients with major depressive disorder: a cross-sectional study

Potential metabolic monitoring indicators of suicide attempts in first episode and drug naive young patients with major depressive disorder: a cross-sectional study

The relationship between depression and risk of metabolic syndrome: a meta‐analysis of observational studies

Dorsolateral and ventrolateral prefrontal cortex structural changes relative to suicidal ideation in patients with depression

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