Association of Metabolic Syndrome Traits and Severity of Kidney Stones: Results From a Nationwide Survey on Urolithiasis in Japan

Kohjimoto, Yasuo; Sasaki, Yumiko; Iwase, Masanori; Matsumura, Nagahide; Inagaki, Takeshi; Hara, Isao

doi:10.1053/j.ajkd.2012.12.028

Cited by 141 publications

(117 citation statements)

References 28 publications

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“…The Third National Health and Nutrition Examination Survey analysis showed that the probability of self-reported US disease is approximately twice as high among patients with MS than those without [21]. Consistent with the findings of Kohjimoto et al [24], a high number of MS components are associated with an increased risk of developing stone disease [21]. A plausible explanation for the association between MS and nephrolithiasis is that MS is associated with lower urine pH, which is an established characteristic of uric acid urolithiasis and a high risk factor for nephrolithiasis [32]–[34].…”

Section: Discussionsupporting

confidence: 84%

“…In addition to diabetes and cardiovascular risks, MS has been associated with US disease in recent studies [21], [23]. Kohjimoto et al reported that the probability of recurring or multiple stones among patients with 4 MS traits was up to 1.8-fold greater than that for patients without MS traits [24]. Their findings indicated that the clustering of MS traits is associated with increased risk of kidney stone formation.…”

Section: Discussionmentioning

confidence: 99%

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Increased Risk of Acute Coronary Syndrome among Patients with Urinary Stone Disease: A Nationwide Population-Based Cohort Study

et al. 2014

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Background/ObjectivesUrinary stones (US) are associated with systemic metabolic and endocrine disorders that share risk factors typically associated with acute coronary syndrome (ACS).MethodsFor this investigation, 30 142 patients with US were set as the research group, and 121 768 randomly selected patients were set as the comparison group through frequency matching by age, sex, and index year. Each patient was individually tracked to identify those who developed ACS during the follow-up period. Cox proportional hazards regression and the Kaplan-Meier method were adopted to calculate the hazard ratios of ACS risk and plot the survival curve.ResultsOverall, 275 (13.4 per 10 000 person-y) and 736 events (9.1 per 10 000 person-y) were observed among patients in the research and comparison cohorts, respectively. The patients with US had a substantially lower ACS-free survival rate compared with that of the patients in the comparison cohort (P<.001). After adjusting for potential risk factors, the patients with US were observed to have a 1.22-fold higher risk of ACS compared with patients in the comparison cohort (95% confidence interval = 1.05–1.40, P<.001), particularly among younger patients.ConclusionsThe results indicate that US is associated with increased risk of developing ACS, particularly among young (≤49 years) and male adults. Future studies should examine the possible mechanisms of US-related ACS morbidity by conducting multicenter recruitment and measurements of laboratory data.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Increased Risk of Acute Coronary Syndrome among Patients with Urinary Stone Disease: A Nationwide Population-Based Cohort Study

et al. 2014

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“…Numerous studies have been put forward the possible association of metabolic syndrome and urolithiasis [34,35]. The metabolic syndrome refers to an array of risk factors for heart diseases and other health issues, such as stroke and diabetes.…”

Section: Albuminuria Metabolic Syndrome and Urolithiasismentioning

confidence: 99%

“…There is an increase in incidences of urolithiasis up to 75% in patients who are overweight or obese [34]. Kohjimoto et al studied that patients with four metabolic traits have 1.8 times greater chances of recurrent stone formation as well as the formation of multiple stones compared to patients that have no traits of the same [35].…”

Section: Albuminuria Metabolic Syndrome and Urolithiasismentioning

confidence: 99%

Albumin and Its Role in Urolithiasis

Raizada

Kumar

Singh

et al. 2017

Asian J Pharm Clin Res

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Urolithiasis is a multifactorial disease with an incidence rate of more than one million cases reported annually in India. Various forms of the calculus have been reported to have 90-95% inorganic and 5% organic matter. Out of the major proteins that comprise this organic component of the matrix, albumin, and uromodulin are found to be the most abundant. Albumin is also the most abundant protein in the human blood serum where it plays the role of a transporter of hormones, fatty acids, and other compounds. The increased concentrations of albumin may significantly affect a patient's susceptibility to kidney stone formation. The study of the role of albumin in urolithiasis could give us useful insights on its potential role in this disease and may add to the therapeutic repertoire of albumin.

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“…[1,2] In addition to obesity, metabolic syndrome, and type 2 diabetes, [3,4] factors such as calcium-deficient diet, and diet rich in salt and animal protein increase the incidence of the disease. [2,5] More than 100 chemical components have been defined in urinary system stones; however, multiple underlying molecular mechanisms of the disease have not been clarified yet.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Efficacy of Chemical Method to Determine Urinary Tract Stone Composition

Kara¹,

Malkoç²,

Tonyalı³

et al. 2017

South Clin Ist Euras

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Objective: The present study evaluated use of chemical method to determine components and category of urinary stones described in current stone disease guidelines.Methods: Chemical analysis of total of 198 urinary stones was performed between March 2014 and September 2015. Calcium, oxalate, uric acid, magnesium, phosphate, cysteine, ammonium, and carbonate were among components detected in stone composition. Stones were divided into groups based on presence of 1, 2, or 3 or more components. Composition results were compared with stone composition data provided in global guidelines.Results: Sixty-five (32.9%) samples consisted of 1 mineral and 133 (67.1%) contained more than 1. Of the total, 107 (54%) compositions were included in European Association of Urology (EAU) guidelines. The 107 samples included 45 (22.7%) with components of calcium oxalate, 22 (11.6%) of calcium phosphate, 11 (6.1%) of calcium and uric acid, 10 (5%) of uric acid, 7 (3.5%) of cysteine, 7 (3.5%) of carbonate apatite, 4 (2%) of ammonium urate, and 1 (0.5%) of magnesium, ammonium, and phosphate. However, 91 (46%) stones consisted of components that are not in current EAU guidelines. Conclusion:Chemical analysis was found insufficient to categorize stone types and components seen in EAU guidelines. There is also a lack of information on the process in the literature. It was concluded that chemical analysis is not the best method to evaluate urinary stones.

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Association of Metabolic Syndrome Traits and Severity of Kidney Stones: Results From a Nationwide Survey on Urolithiasis in Japan

Cited by 141 publications

References 28 publications

Increased Risk of Acute Coronary Syndrome among Patients with Urinary Stone Disease: A Nationwide Population-Based Cohort Study

Increased Risk of Acute Coronary Syndrome among Patients with Urinary Stone Disease: A Nationwide Population-Based Cohort Study

Albumin and Its Role in Urolithiasis

Evaluation of the Efficacy of Chemical Method to Determine Urinary Tract Stone Composition

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