Association of metabolic syndrome with pediatric psoriasis: a case‐control study in Kabul, Afghanistan

Aalemi, Ahmad Khalid; Hamdard, Abdul Ghafar; Chen, Hong-Xiang

doi:10.1111/ijd.14805

Cited by 11 publications

(11 citation statements)

References 24 publications

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“…All studies reported the pooled prevalence of MetS among patients with psoriasis; of them, 15 described this prevalence in men and women, 38 reported the prevalence in adults, 15–22,24–26,28,29,31–36,38,40–44,46–52,54–57,59 and 4 reported the prevalence in children and teenagers 30,37,53,58 . Fifteen studies 17,19–22,32,34,37,38,40,44,45,49,50,59 analysed the prevalence of combined MetS in patients with mild, moderate and severe psoriasis.…”

Section: Resultsmentioning

confidence: 99%

“…All studies reported the pooled prevalence of MetS among patients with psoriasis; of them, 15 described this prevalence in men and women, 38 reported the prevalence in adults, [15][16][17][18][19][20][21][22][24][25][26]28,29,[31][32][33][34][35][36]38,[40][41][42][43][44][46][47][48][49][50][51][52][54][55][56][57]59 and 4 reported the prevalence in children and teenagers. 30,37,53,58 Fifteen studies 17,[19][20][21][22]32,34,37,38,40,<...…”

Section: General Study Characteristicsmentioning

confidence: 99%

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Global prevalence of metabolic syndrome in patients with psoriasis in the past two decades: current evidence

Liu

Cai

Sun

et al. 2022

Acad Dermatol Venereol

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Patients with psoriasis are at an increased risk of metabolic syndrome (MetS); however, a systematic analysis of its global prevalence has not been performed to date. Here, we performed a systematic review and meta‐analysis to assess the prevalence of MetS among patients with psoriasis. We searched five databases from inception through September 2021 and used the Agency for Healthcare Research and Quality (AHRQ) and Newcastle–Ottawa Scale (NOS) tools to assess observational study quality. Stata SE 15.1 was used to perform the data analysis. Subgroup, meta‐regression and sensitivity analyses were used to evaluate interstudy heterogeneity. Publication bias was evaluated using Egger's and Begg's linear tests. The global prevalence of MetS in patients with psoriasis was 32% (95% confidence interval [CI], 0.26–0.38). The prevalence in adults was 32% (95% CI, 0.29–0.36), while that in children and adolescents was 9% (95% CI, 0.00–0.18). Latin America had the highest prevalence of 47% (95% CI, 0.43–0.51), whereas North America had the lowest prevalence of 26% (95% CI, 0.16–0.37). Patients with psoriasis vulgaris (29%; 95% CI, 0.23–0.35) or severe psoriasis (37%; 95% CI, 0.27–0.46) had a higher prevalence of MetS than those with other psoriasis types. These findings suggest that MetS should be appropriately recognized and managed in patients with psoriasis. More population‐based prospective observational studies are required to elucidate the mechanisms underlying the coexistence of MetS in patients with psoriasis.

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Section: Resultsmentioning

confidence: 99%

“…All studies reported the pooled prevalence of MetS among patients with psoriasis; of them, 15 described this prevalence in men and women, 38 reported the prevalence in adults, [15][16][17][18][19][20][21][22][24][25][26]28,29,[31][32][33][34][35][36]38,[40][41][42][43][44][46][47][48][49][50][51][52][54][55][56][57]59 and 4 reported the prevalence in children and teenagers. 30,37,53,58 Fifteen studies 17,[19][20][21][22]32,34,37,38,40,<...…”

Section: General Study Characteristicsmentioning

confidence: 99%

Global prevalence of metabolic syndrome in patients with psoriasis in the past two decades: current evidence

Liu

Cai

Sun

et al. 2022

Acad Dermatol Venereol

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“…As depicted in Table 1, 21 studies examined the relationship between MetS and psoriasis with a total population of 11,826 patients. All studies had an average age range between 35 and 53 years old, except one study in which children with an average age of 13 years old were under investigation 48 . Ninteen of 21 studies recorded that psoriasis patients are greatly more affected by MetS 29–32,35–49 .…”

Section: Resultsmentioning

confidence: 99%

“…one study in which children with an average age of 13 years old were under investigation. 48 Ninteen of 21 studies recorded that psoriasis patients are greatly more affected by MetS. [29][30][31][32][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] Howbeit, statistical analysis results, following the removal of adjusted variables in one study, were altered.…”

Section: Vitiligomentioning

confidence: 99%

Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta‐analysis of case‐control studies

Sodagar,

Ghane,

Heidari

et al. 2023

Health Science Reports

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Background and AimMetabolic syndrome (MetS) is a well‐known noncommunicable disease that plays a significant role in emerging other chronic disorders and following complications. MetS is also involved in the pathophysiology of numerous dermatological diseases. We aim to evaluate the association of MetS with the most prevalent dermatological diseases.MethodsA systematic search was carried out on PubMed, Science Direct, Web of Science, Cochrane, as well as the Google Scholar search engine. Only English case‐control studies regarding MetS and any skin disease from the beginning of 2010 up to November 15, 2022, were selected. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA).ResultsA total of 37 studies (13,830 participants) met the inclusion criteria. According to our result, patients with psoriasis, hidradenitis suppurativa (HS), vitiligo, androgenetic alopecia (AGA), and lichen planus (LP) have a higher chance of having MetS compared to the general population. Furthermore, people with seborrheic dermatitis (SED) and rosacea are more prone to insulin resistance, high blood pressure (BP), and higher blood lipids. After pooling data, the meta‐analysis revealed a significant association between MetS and skin diseases (pooled odds ratio [OR]: 3.28, 95% confidence interval: 2.62−4.10). Concerning the type of disease, MetS has been correlated with AGA (OR: 11.86), HS (OR: 4.46), LP (OR: 3.79), and SED (OR: 2.45). Psoriasis also showed a significant association but with high heterogeneity (OR: 2.89). Moreover, skin diseases and MetS are strongly associated in Spain (OR: 5.25) and Thailand (OR: 11.86). Regarding the metaregression model, the effect size was reduced with increasing age (OR: 0.965), while the size increased with AGA (OR: 3.064).ConclusionsMetS is closely associated with skin complications. Dermatologists and other multidisciplinary teams should be cautious while treating these patients to prevent severe complications resulting from MetS.

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“…In an anthropometric survey of 113 children with psoriasis and 113 healthy children in Kabul (Afghanistan), researchers found that children with psoriasis had higher body weight and central obesity than children in the control group (27.4 % vs. 12.4 %, OR=2.67; р=0.005 and 23 % vs. 9.7 %, OR=2.77; р=0.007, respectively). In addition, sick children had higher family history of skin diseases (23.0 % vs. 13.7 %; р<0.001) [1]. The importance of such a factor in the development of psoriasis as body weight and the presence of obesity in children is emphasized by the results of other studies [21].…”

Section: Indicatorsmentioning

confidence: 91%

Total, longitudinal and transverse body sizes in men with psoriasis of different somatotypes

et al. 2021

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Using a constitutional approach to predict the onset of a disease can be key not only to solving the problem of late-stage lifestyle modification therapy but also to understanding the deep, seemingly incomprehensible links between organs and body structure. The aim of the study was to establish and analyze the differences in total, longitudinal and transverse body sizes between healthy and/or psoriatic men of different somatotypes depending on the severity of the disease. Anthropo-somatotypological examination was performed on Ukrainian men (aged 22 to 35 years) with psoriasis (n=100, including 32 with mild and 68 with severe). A clinical assessment of the severity and area of psoriatic lesions was performed using the PASI index. Anthropometric data of 82 practically healthy men of the same age group was taken from the data bank of the research center of National Pirogov Memorial Medical University, Vinnytsya. Statistical processing of the obtained results was performed in the license package “Statistica 5.5” using non-parametric evaluation methods. In patients with mild and severe psoriasis, men of mesomorphic and endo-mesomorphic somatotypes in comparison with healthy men of the corresponding somatotypes, higher values of almost all total (in the endo-mesomorphs with severe disease), transverse (except for shoulder width) and lateral body size (except endo-mesomorphs with severe disease) was found. In patients with psoriasis, men of endo-mesomorphic somatotype with a mild course of the disease found greater than in patients with a similar course men of mesomorphic somatotype, body weight, length and surface area, height of acromial and finger anthropometric points, and transverse middle thoracic diameters and anteroposterior middle thoracic diameter; and in patients with psoriasis men of endo-mesomorphic somatotype with a severe course of the disease – only greater values than in patients with a similar course of the disease men of mesomorphic somatotype, interspinous distance. When comparing the total, longitudinal and transverse dimensions of the body between men with psoriasis of the corresponding somatotypes, in representatives of the mesomorphic somatotype with a mild course of the disease found greater than with severe course, body length values and lower – posterior middle thoracic diameter. The revealed differences in total, longitudinal and transverse body sizes between healthy and/or patients with mild or severe psoriasis Ukrainian men of mesomorphic and endo-mesomorphic somatotypes provide an opportunity to increase the effectiveness of the use of body structure and size to identify risk groups psoriasis.

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Association of metabolic syndrome with pediatric psoriasis: a case‐control study in Kabul, Afghanistan

Cited by 11 publications

References 24 publications

Global prevalence of metabolic syndrome in patients with psoriasis in the past two decades: current evidence

Global prevalence of metabolic syndrome in patients with psoriasis in the past two decades: current evidence

Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta‐analysis of case‐control studies

Total, longitudinal and transverse body sizes in men with psoriasis of different somatotypes

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