Association of Meteorin-Like Hormone with insulin resistance and body composition in healthy Iranian adults

Alizadeh, Hamid; Alizadeh, Ali

doi:10.1016/j.dsx.2020.05.031

Cited by 7 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zheng et al reported that mice specifically overexpressing Metrnl in adipocytes were protected from diet-induced insulin resistance [17]. Many literature studies have reported that subfatin is associated with insulin resistance [9,10,[16][17][18]. The current study showed that the serum subfatin level is lower in the obese group, and a low serum subfatin level increases insulin resistance.…”

Section: Discussionsupporting

confidence: 52%

Düşük serum meteorin benzeri/subfatin seviyesi, obezite ve insülin direnci ile ilişkilidir

Cavlı

Önalan

Yakar

et al. 2022

Family Practice and Palliative Care

View full text Add to dashboard Cite

Introduction: Meteorin-like (Metrnl), also known as subfatin is a newly discovered adipokine of adipocyte origin that may play a role in obesity and insulin resistance. The current study aimed to investigate the association between subfatin and biochemical values, demographic characteristics, and insulin resistance in obese patients and healthy controls.Methods: This cross-sectional study included 59 obese patients with sex and age-matched group of 41 healthy controls. An enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Subfatin (Metrnl), and the correlations of Metrnl level with anthropometric parameters, HOMA index, and biochemical measurements were assessed.Results: The levels of BMI (p<0.001), insulin (p=0.002), and HOMA-IR score (p<0.001) were significantly higher in obese patients than controls. The serum levels of Subfatin were found to be lower in obese patients (1.85 [1.35–5.51] ng/ml) compared to the healthy controls (21.82 [12.61–27.76] ng/ml) (p<0.001). Subfatin had a significantly negative relationship with age (r =-0.250, p=0.012), weight (r =-0.373, p=0.001), BMI (r =-0.492, p=0.001), HbA1c (r =-0.209, p=0.037), LDL (r =-0.264, p=0.008), HOMA-IR (r =-0.223, p=0.026), and glucose (r =-0.376, p<0.001). There was a significantly positive correlation between subfatin and height (r=0.321, p=0.001).Conclusion: These results show that levels of subfatin were decreased in obese patients. There is a relationship between circulating amounts of subfatin hormone and age, weight, height, LDL-cholesterol, glucose, hbA1c, and HOMA-IR. Subfatin might be a new biomarker of obesity and insulin resistance.Keywords: Meteorin-like/subfatin, adiposity, insulin resistance, adipokines, biomarkers, diabetes mellitus type 2

show abstract

Section: Discussionsupporting

confidence: 52%

Düşük serum meteorin benzeri/subfatin seviyesi, obezite ve insülin direnci ile ilişkilidir

Cavlı

Önalan

Yakar

et al. 2022

Family Practice and Palliative Care

View full text Add to dashboard Cite

show abstract

“…Notably, part of these reports lacked indicator data concerning insulin resistance and insulin sensitivity, which was challenging to explain the negative correlation between blood Metrnl and FBG. Furthermore, a study on healthy Iranian adults also concerned with FBG showed a negative correlation with baseline plasma Metrnl (83). It is worth noting that Metrnl was found to be lower in COPD patients with comorbidities such as T2DM and CAD, instead, higher Metrnl level in protopathic exacerbations (56).…”

Section: Metrnl and Diabetesmentioning

confidence: 94%

“…Many clinical researchers have analyzed the correlation between Metrnl and insulin resistance in diabetes or prediabetes via calculating this index, but the results seemed a little controversial. A study on healthy Iranian adults found plasma Metrnl in recreational athletes increased significantly compared to sedentary subjects after correcting the insulin resistance degree (83). In contrast, baseline plasma Metrnl remained no different.…”

Section: Metrnl and Insulin Sensitivitymentioning

confidence: 98%

“…Notably, this negative association was prone to arise in T2DM patients compared with other diseases. Actually, it seems more studies figured out that there is no relationship between Metrnl and BMI in healthy or metabolic syndrome (31,52,80,83,87,89,95,99,100). Apart from total height and body weight, the waist-to-hip ratio (WHR) was further measured but still no correlation (52).…”

Section: Metrnl and Obesitymentioning

confidence: 99%

See 1 more Smart Citation

Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies

Gao

Sun

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Meteorin-like, also known as Metrnl, Meteorin-β, Subfatin, and Cometin, is a novel secreted protein exerting pleiotropic effects on inflammation, immunology, and metabolism. Earlier research on this hormone focused on regulating energy expenditure and glucose homeostasis. Consequently, several studies attempted to characterize the molecule mechanism of Metrnl in glucose metabolism and obesity-related disorders but reported contradictory clinical results. Recent studies gradually noticed its multiple protective functions in inflammatory immune regulations and cardiometabolic diseases, such as inducing macrophage activation, angiogenesis, tissue remodeling, bone formation, and preventing dyslipidemias. A comprehensive understanding of this novel protein is essential to identify its significance as a potential therapeutic drug or a biomarker of certain diseases. In this review, we present the current knowledge on the physiology of Metrnl and its roles in inflammation, immunology, and metabolism, including animal/cell interventional preclinical studies and human clinical studies. We also describe controversies regarding the data of circulation Metrnl in different disease states to determine its clinical application better.

show abstract

“…Physical activity affects reproductive hormones and ovulation (Ahrens et al, 2014). During performing physical activity, skeletal muscles produce and release myokines in autocrine, paracrine, and endocrine behaviors, thus the body's metabolism increases, which proliferates insulin sensitivity and fat oxidation (Alizadeh & Alizadeh, 2020). The increase of body fat is caused by the consumption of unhealthy and low nutrient foods (Ruano, Lucumi, Albán, Arteaga, & Fors, 2018), which is related to obesity that could cause reproductive disorders (Pasquali et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Aerobic Exercise Has Positive Effects on Menstrual Cycle

Tamher

Fitri

Pitriani

2021

J. pendidik. jasmani olahraga

View full text Add to dashboard Cite

The purpose of this study was to determine the effect of aerobic exercise on obese women. The research design used was a pretest-posttest two treatment design. The subjects involved in this study were 22 women divided into 2 groups, including the aerobic exercise group and the zumba group. This study was conducted 3 times a week for 12 weeks with 65-85% intensity of the maximum pulse rate. Menstrual cycle data were obtained using the interview technique and menstrual questionnaire. The results of this study indicated that aerobic exercise and zumba did not affect the menstrual cycle. Although the study data showed no increase or decrease in menstrual cycles after endurance training, overall subjects experienced positive psychological improvements and decreased menstrual pain.This study concludes that aerobic exercise is good to do because it does not affect the menstrual cycle.

show abstract

Association of Meteorin-Like Hormone with insulin resistance and body composition in healthy Iranian adults

Cited by 7 publications

References 22 publications

Düşük serum meteorin benzeri/subfatin seviyesi, obezite ve insülin direnci ile ilişkilidir

Düşük serum meteorin benzeri/subfatin seviyesi, obezite ve insülin direnci ile ilişkilidir

Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies

Aerobic Exercise Has Positive Effects on Menstrual Cycle

Contact Info

Product

Resources

About