Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta-analysis

Zeng, Xian‐Tao; Lu, Junti; Tang, Xiangjun; Weng, Hong; Luo, Jie

doi:10.3892/br.2014.248

Cited by 7 publications

(5 citation statements)

References 31 publications

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“…Meanwhile, we observed that A66G variant was associated with increased meningioma and glioma susceptibility in Asian. Our results are consistent with a previous meta-analysis showing that MTRR rs1801394 polymorphism may increase the risk of meningioma [ 39 ].…”

Section: Discussionsupporting

confidence: 93%

Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults

et al. 2017

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Polymorphic variants of genes involved in folate metabolism are implicated in the susceptibility to meningioma and glioma, but the results from published articles are controversial and inconclusive. Therefore, we performed this meta-analysis including all studies available to evaluate the relationship between folate metabolism genetic polymorphisms and the susceptibility to meningioma and glioma in adults. We searched the literature in PubMed, EMBASE and Cochrane Central Library for relevant articles published up to August 2016. The odds ratios (ORs) and the corresponding 95% confidence intervals (95%Cls) were used to evaluate the associations of two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) with the risk of meningioma and glioma in adults. We found significant association of MTHFR A1298C (rs1801131) variant genotypes with increased incidence of meningioma and glioma in this study population (CA vs. AA: OR=1.22, P<0.001; CA+CC vs. AA: OR=1.18, P=0.002). Moreover, we found that MTRR A66G (rs1801394) variant genotypes was associated with increased risk of meningioma and glioma (G vs. A: OR=1.11, P=0.020; GG vs. AA+AG: OR=1.17, P=0.043; GG vs. AA: OR=1.22, P=0.023). In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.

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Section: Discussionsupporting

confidence: 93%

Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults

et al. 2017

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“…The predominant genotype found in Japanese (Suzuki et al, 2008), Chinese (Yang et al, 2013) and African (Shi et al, 2003) population for MTRR A66G polymorphism is AA genotype (Table S5). We observed a decreased risk association for glioma with AG genotype of MTRR enzyme in our study population but no such association for glioma risk with AG genotype was observed in Chinese Han (Zeng et al, 2014;Zhang et al, 2013), British or European (Bethke et al, 2008) population. We did not observe any risk association for meningioma with MTRR A66G SNP in our study population but the Chinese Han population (Zhang et al, 2013) showed AG genotype of MTRR A66G as a risk factor for adult meningioma and a study in British population (Bethke et al, 2008) and meta-analysis in European population (Zeng et al 2014) showed homozygous polymorphism of MTRR GG genotype to be associated with increased risk for meningioma.…”

Section: Discussioncontrasting

confidence: 64%

“…We observed no significant association of increased risk for development of glioma or meningioma with MTR A2756G SNP. Other meta-analysis studies on European descent and Asian population also reported of no risk association with MTR A2756G for either with glioma or meningioma (Zeng et al, 2014).…”

Section: Discussionmentioning

confidence: 93%

Association of Single Nucleotide Polymorphisms (SNPs) in Genes Encoding for Folate Metabolising Enzymes with Glioma and Meningioma in Indian Population

Kumawat

Gowda

Debnath

et al. 2018

Asian Pac J Cancer Prev

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Background: The association of primary brain tumors with Single Nucleotide polymorphisms (SNPs) in genes of folate metabolising enzymes have been reported to vary among different ethnic population. Here, we have studied the association of SNPs of folate metabolizing genes with the primary brain tumors (glioma and meningioma) in North Indian population. Methods: SNPs of genes coding for folate metabolizing enzymes was carried out in 288 study population from North India [Glioma (n=108), Meningioma (n=76) and healthy-control (n=104)]. The allele-specific polymerase chain reaction (ARMS-PCR) was used to analyse the SNP A1298C of the MTHFR (Methylenetetrahydrofolate-reductase) and the SNP A66G of the methionine synthase reductase (MTRR) genes. The PCR-RLFP (Restriction Fragment Length Polymorphism) was used to analyse the SNP C677T of the Methylene tetrahydrofolate-reductase and the SNP A2756G of the methionine-synthase (MTR) genes. Serum homocysteine, vitamin B 12 and folate levels were evaluated in controls/patients serum using Chemiluminescence immunoassay and the levels were correlated with SNPs genotype. Results: The CC genotype of MTHFR A1298C was observed to have reduced risk of having meningioma than AA genotype (odd ratio=0.62, 95%CI 0.32-0.97, p=0.03). Similarly, the AG genotype of MTRR A66G showed reduced risk of glioma than AA genotype (odd ratio=0.56, 95%CI 0.32-0.97, p=0.039). Furthermore, in patients with AA genotype of MTR A2756G and CT genotype of MTHFR C677T showed higher serum homocysteine level than GG genotype (8.6 µmol/L, p=0.048) and CC genotype (11.2µmol/L, p=0.039) respectively. Conclusion: Our findings provide an insight into the risk association of SNPs in MTHFR A1298C and MTRR A66G genes with glioma/meningioma patients. Further studies are needed to evaluate their clinical implications.

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“…Xu et al found that significantly increased meningioma risk was only observed under the TC vs CC model in a meta-analysis of four studies 9. A meta-analysis by Zeng et al showed that the MTRR rs1801394 polymorphism (seven case-control studies), but not MTR rs1805087 (seven case-control studies), may be associated with meningioma risk in adults 8. We removed data that did not meet the HWE, such as the rs1805087 data of Zhang et al,20 and added data from case-control studies, such as the WHO grade III meningioma group 21.…”

Section: Discussionmentioning

confidence: 99%

“…There were several previous meta-analyses for associations between meningioma risk and gene polymorphisms, including MTHFR rs1801133, MTRR rs1801394, MTR rs1805087, GSTM1 null/present, and GSTT1 null/present 8–13. However, an updated meta-analysis was still required.…”

Section: Introductionmentioning

confidence: 99%

Genetic variants and increased risk of meningioma: an updated meta-analysis

Han

Wang

et al. 2017

OTT

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PurposeVarious genetic variants have been reported to be linked to an increased risk of meningioma. However, no confirmed conclusion has been obtained. The purpose of the study was to investigate potential meningioma-associated gene polymorphisms, based on published evidence.Materials and methodsAn updated meta-analysis was performed in September 2016. After electronic database searching and study screening, we selected eligible case-control studies and extracted data for meta-analysis, using Mantel–Haenszel statistics. P-values, pooled odds ratios (ORs), and 95% confidence intervals were calculated.ResultsWe finally selected eight genes with ten polymorphisms: MLLT10 rs12770228, CASP8 rs1045485, XRCC1 rs1799782, rs25487, MTHFR rs1801133, rs1801131, MTRR rs1801394, MTR rs1805087, GSTM1 null/present, and GSTT1 null/present. Results of meta-analyses showed that there was increased meningioma risk in case groups under all models of MLLT10 rs12770228 (all OR >1, P<0.001), compared with control groups. Similar results were observed under the allele, homozygote, dominant, and recessive models of MTRR rs1801394 (all OR >1, P<0.05), and the heterozygote and dominant models of MTHFR rs1801131 in the Caucasian population (all OR >1, P<0.05). However, no significantly increased meningioma risks were observed for CASP8 rs1045485, XRCC1 rs25487, rs1799782, MTHFR rs1801133, MTR rs1805087, or GSTM1/GSTT1 null mutations.ConclusionOur updated meta-analysis provided statistical evidence for the role of MLLT10 rs12770228, MTRR rs1801394, and MTHFR rs1801131 in increased susceptibility to meningioma.

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Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta-analysis

Cited by 7 publications

References 31 publications

Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults

Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults

Association of Single Nucleotide Polymorphisms (SNPs) in Genes Encoding for Folate Metabolising Enzymes with Glioma and Meningioma in Indian Population

Genetic variants and increased risk of meningioma: an updated meta-analysis

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