Association of MicroRNA-210 and MicroRNA-155 with severity of preeclampsia

Youssef, Hanan Mohamed Gabr; Marei, Elham Sayed

doi:10.1016/j.preghy.2019.05.010

Cited by 16 publications

(12 citation statements)

References 24 publications

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“…Its increased expression level was associated with a decreased level of pro-angiogenic factor, VEGF, in an experimental rat model of PE (Cheng et al, 2011). Newly performed studies have reported significantly higher levels of miRNA-155 in the maternal peripheral blood of women with compared to women without PE (Ayoub et al, 2019;Youssef and Marei, 2019;Witvrouwen et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…It might therefore be anticipated that dysfunction of miRNA expression could be important for the development of PE. Studies recently published explored a possible causal relationship between miRNA expression and PE (Youssef and Marei, 2019;Hemmatzadeh et al, 2020). It has been demonstrated that expression levels of miRNAs in different tissues play a role in physiological pregnancy as regulators of trophoblast proliferation, migration, invasion, apoptosis, differentiation, cellular metabolism and placental angiogenesis (Hayder et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Preeclamptic Women Have Disrupted Placental microRNA Expression at the Time of Preeclampsia Diagnosis: Meta-Analysis

Ćirković

Stanisavljević

Milin-Lazović

et al. 2021

Front. Bioeng. Biotechnol.

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Introduction: Preeclampsia (PE) is a pregnancy-associated, multi-organ, life-threatening disease that appears after the 20th week of gestation. The aim of this study was to perform a systematic review and meta-analysis to determine whether women with PE have disrupted miRNA expression compared to women who do not have PE.Methods: We conducted a systematic review and meta-analysis of studies that reported miRNAs expression levels in placenta or peripheral blood of pregnant women with vs. without PE. Studies published before October 29, 2021 were identified through PubMed, EMBASE and Web of Science. Two reviewers used predefined forms and protocols to evaluate independently the eligibility of studies based on titles and abstracts and to perform full-text screening, data abstraction and quality assessment. Standardized mean difference (SMD) was used as a measure of effect size.Results: 229 publications were included in the systematic review and 53 in the meta-analysis. The expression levels in placenta were significantly higher in women with PE compared to women without PE for miRNA-16 (SMD = 1.51,95%CI = 0.55–2.46), miRNA-20b (SMD = 0.89, 95%CI = 0.33–1.45), miRNA-23a (SMD = 2.02, 95%CI = 1.25–2.78), miRNA-29b (SMD = 1.37, 95%CI = 0.36–2.37), miRNA-155 (SMD = 2.99, 95%CI = 0.83–5.14) and miRNA-210 (SMD = 1.63, 95%CI = 0.69–2.58), and significantly lower for miRNA-376c (SMD = –4.86, 95%CI = –9.51 to –0.20). An increased level of miRNK-155 expression was found in peripheral blood of women with PE (SMD = 2.06, 95%CI = 0.35–3.76), while the expression level of miRNA-16 was significantly lower in peripheral blood of PE women (SMD = –0.47, 95%CI = –0.91 to –0.03). The functional roles of the presented miRNAs include control of trophoblast proliferation, migration, invasion, apoptosis, differentiation, cellular metabolism and angiogenesis.Conclusion: miRNAs play an important role in the pathophysiology of PE. The identification of differentially expressed miRNAs in maternal blood creates an opportunity to define an easily accessible biomarker of PE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preeclamptic Women Have Disrupted Placental microRNA Expression at the Time of Preeclampsia Diagnosis: Meta-Analysis

Ćirković

Stanisavljević

Milin-Lazović

et al. 2021

Front. Bioeng. Biotechnol.

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“…In contrast, [11] reported that MicroRNA-155 could not be used as a prognostic biomarker for severity of Preeclampsia.…”

Section: Discussionmentioning

confidence: 96%

Role of MicroRNA-155 in Pathogenesis and Prognosis of Preeclampsia pregnancies

Tolba

Abdelrahman

Sakr

et al. 2020

Benha Journal of Applied Sciences

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Preeclampsia (PE) is a medical condition characterized by hypertension and proteinuria in pregnant females following 20 weeks of gestation. It is the most common cause of fetal morbidity and mortality, which has no curative therapeutic strategy, except for delivery of the placenta. The association between PE and aberrant microRNA (miRNA) expression in placentas was first reported in 2007 and a number of other similar findings have since been demonstrated.The aim of this study was to assess the level of expression of miR-155 in Egyptian women with preeclampsia and its role in pathogenesis and prognosis of the disease. This study was a case control study included a total of 40 pregnant females; 9 cases with early onset PEdiagnosed < 34 weeks of gestation whose mean age was 32.4 years, and 21 case of late onset PEdiagnosed ≥ 34 weeks of gestation whose mean age was 32.2 years admitted to the obstetrics and gynaecology department, Banha University Hospitals, in addition to 10 normotensive pregnant women of matched age as a control group. MIRNA 155 expression level were in PE cases when compared to control groups (p<0.001). MIRNA 155 expression level showed no significant difference between early onset and late onset PE. miRNA 155 expression showed significantly higher level in PE than normotensive pregnant females with no difference between early and late onset PE.

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“…Wang, Cheng, et al, 2019). Several miRNAs seem to be differentially expressed in serum and plasma of PE pregnancies (Jairajpuri et al, 2017;Youssef & Marei, 2019;Zhong et al, 2019). The upregulation of miR-518b, miR-517-5p, miR-520h, and miR-206 is associated with future risk of PE, which might pave the path for early diagnosis of the disease (Akehurst et al, 2015;Hromadnikova et al, 2017;Srinivasan et al, 2020).…”

Section: Ncrnas Mediated Regulations In Pementioning

confidence: 99%

“…Downregulated miRNAs such as miR‐454, miR‐141‐5p, miR‐652‐3p too are involved in proliferative, apoptotic, and invasive pathways of trophoblast cells by targeting ephrin receptor B4 (EPHB4), activating transcription factor 2, and homeobox A9 (HOXA9), that are involved in regulating trophoblast cell function, MAPK/ERK pathway and trophoblast cell function, respectively (Shi et al, 2019; Wang & Yan, 2018; Y. Wang, Cheng, et al, 2019). Several miRNAs seem to be differentially expressed in serum and plasma of PE pregnancies (Jairajpuri et al, 2017; Youssef & Marei, 2019; Zhong et al, 2019). The upregulation of miR‐518b, miR‐517‐5p, miR‐520h, and miR‐206 is associated with future risk of PE, which might pave the path for early diagnosis of the disease (Akehurst et al, 2015; Hromadnikova et al, 2017; Srinivasan et al, 2020).…”

Section: Ncrnas In Women's Healthmentioning

confidence: 99%

Non‐coding RNAs and their cross‐talks impacting reproductive health of women

et al. 2021

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Non‐coding RNAs (ncRNAs) work as crucial posttranscriptional modulators of gene expression regulating a wide array of biological processes that impact normal physiology, including reproductive health. The health of women, especially reproductive health, is now a prime focus of society that ensures the females' overall physical, social, and mental well‐being. Furthermore, there has been a growing cognizance of ncRNAs' possible applications in diagnostics and therapeutics of dreaded diseases. Hence, understanding the functions and mode of actions of ncRNAs in the context of women's health will allow us to develop effective prognostic and therapeutic strategies that will enhance the quality of life of women. Herein, we summarize recent progress on ncRNAs, such as microRNAs (miRNAs) and long ncRNAs (lncRNAs), and their implications in reproductive health by tying the knot with lifestyle factors that affect fertility complications, pregnancy outcomes, and so forth. We also discourse the interplay among the RNA species, especially miRNAs, lncRNAs, and protein‐coding RNAs, through the competing endogenous RNA regulations in diseases of women associated with maternal and fetal health. This review provides new perspectives correlating ncRNAs, lifestyle, and reproductive health of women, which will attract future studies to improve women's lives. This article is categorized under: RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs

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Association of MicroRNA-210 and MicroRNA-155 with severity of preeclampsia

Cited by 16 publications

References 24 publications

Preeclamptic Women Have Disrupted Placental microRNA Expression at the Time of Preeclampsia Diagnosis: Meta-Analysis

Preeclamptic Women Have Disrupted Placental microRNA Expression at the Time of Preeclampsia Diagnosis: Meta-Analysis

Role of MicroRNA-155 in Pathogenesis and Prognosis of Preeclampsia pregnancies

Non‐coding RNAs and their cross‐talks impacting reproductive health of women

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