Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case–control study

Abstract

BackgroundMicroRNA (miRNA) polymorphisms may alter miRNA-related processes, and they likely contribute to cancer susceptibility. Various studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers; however, few studies have focused on head and neck squamous cell carcinoma (HNSCC) risk. This study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese population.MethodsIn this study, we genotyped five common single-nucleotide polymorphisms (SNPs) in several key miRNAs (miR-149 rs2292832, miR-146a rs2910164, miR-605 rs2043556, miR-608 rs4919510, and miR-196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case–control study including 576 cases and 1552 controls, which were matched by age and sex in a Chinese population.ResultsThe results revealed that miR-605 rs2043556 [dominant model: adjusted odds ratio (OR) 0.71, 95% confidence interval (CI) 0.58–0.88; additive model: adjusted OR 0.74, 95% CI 0.62–0.89] and miR-196a2 rs11614913 (dominant model: adjusted OR 1.36, 95% CI 1.08–1.72; additive model: adjusted OR 1.28, 95% CI 1.10–1.48) were significantly associated with the risk of oral squamous cell carcinoma (OSCC). Furthermore, when these two loci were evaluated together based on the number of putative risk alleles (rs2043556 A and rs11614913 G), a significant locus-dosage effect was noted on the risk of OSCC (Ptrend < 0.001). However, no significant association was detected between the other three SNPs (miR-149 rs2292832, miR-146a rs2910164, and miR-608 rs4919510) and HNSCC risk.ConclusionOur study provided the evidence that miR-605 rs2043556 and miR-196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population.

microRNA-605 rs2043556 polymorphisms affect clopidogrel therapy through modulation of CYP2B6 and P2RY12 in acute coronary syndrome patients

“…Interestingly, we revealed that miR-605 rs2043556 A/G polymorphisms are significantly associated with UA and AMI. This potentially functional polymorphism within miR-605 has been reported to be associated with the risk of certain types of cancers in Chinese individuals [25][26][27]. We also demonstrated that the expression of mature miR-605 in cells transfected with the miR-605 rs2043556 G group is lower than that in cells transfected with rs2043556 A, which is consistent with studies of miR-605 in Li-Fraumeni syndrome [24].…”

Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population

“…Several studies have investigated the association between miR-605 rs2043556:T>C and cancer risk [ 82 ]. Specifically, the miR-605 C allele was associated with an increased risk of bladder cancer in a Caucasian population [ 60 ], and in gastrointestinal cancer, the C allele was significantly less common in the controls vs. cancer patients in an Asian population [ 31 ].…”

“…Specifically, the miR-605 C allele was associated with an increased risk of bladder cancer in a Caucasian population [ 60 ], and in gastrointestinal cancer, the C allele was significantly less common in the controls vs. cancer patients in an Asian population [ 31 ]. However, rs2043556-C significantly decreased the oral squamous cell carcinoma risk in a Chinese population [ 82 ]. Only one article and one meta-analysis have evaluated the association between rs2043556 and BC risk.…”

A Brief review of Circulating MicroRNAs and Essential Hypertension

“…A polymorphism of miRNA 605 gene was associated with increased risk of squamous cell carcinoma (Miao et al, 2016), Li-Fraumeni syndrome (Id Said and Malkin, 2015), prostate cancer (Huang et al, 2014), and gastrointestinal cancer (Zhang et al, 2012). MiRNA 605 was downregulated in melanoma cell lines and suppressed melanoma cell growth both in vitro and in vivo.…”