Association of mir-499 gene polymorphism with some hormones in type 2 diabetes mellitus patients

Mohsen, Israa Harjan; Zaidan, Haider K.; Nassir, Ishtar Munim; Al-Saadi, Ali Hmood; Al-Terehi, Mona N.; Al-Jboori, Methaq J

doi:10.5958/0976-5506.2018.01730.8

Cited by 4 publications

(3 citation statements)

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“…The flow diagram and data related to screening are shown in Figure 1 . Among 15 included studies[ 28 37 38 39 40 41 42 43 44 45 46 47 48 49 50 ] (32 polymorphisms), we found two articles for two single-nucleotide polymorphisms (rs3820455 and rs11888095), three studies were included for rs3746444 and rs531564 polymorphisms, and also more than three studies were included for each of the following polymorphisms (rs895819, rs11614913, and rs2910164). These data are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Association of microRNA gene polymorphisms with Type 2 diabetes mellitus: A systematic review and meta-analysis

et al. 2020

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Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder with growing prevalence and increasing economic burden. Based on the role of genetics and epigenetic factors on T2DM, we aimed to carry a systematic review and meta-analysis for all miRNA gene polymorphisms and risk of T2DM. Materials and Methods: A computerized literature search was carried out on PubMed, Web of Science, Scopus, Embase, as well as references of relevant review/meta-analysis. Key search terms were “Diabetes Mellitus, Type 2,” “MicroRNAs,” and “Polymorphism, Single Nucleotide.” All types of observational studies from January 1, 1992, to November 30, 2019, were included, without language restriction. Data analysis was performed using R programming language (3.5.2). Level of heterogeneity was obtained by Cochran's Q test ( P < 0.05), and subgroup analysis was performed based on ethnicity. Results: Thirty-two polymorphisms from fifteen articles were included. Meta-analysis was carried out based on minor allele frequencies. Seven studies with 2193 cases and 3963 controls were included for rs2910164 polymorphism. In subgroup analysis, there were significant results in Caucasian population in dominant model (odds ratio [OR] =1.12; 95% confidence interval [CI]: 0.83–1.51), homozygote model (OR = 1.78; 95% CI: 1.06–3.00), heterozygote model (OR = 1.77; 95% CI: 1.03–3.05), and recessive model (OR = 1.78; 95% CI: 1.07–2.96). Four studies with 2085 cases and 1933 controls were included for rs895819 polymorphism. Overall, there was no significant result for association with rs895819, but subgroup analysis revealed that minor allele significantly decreased the risk of T2DM in Caucasians by recessive model (OR = 0.34; 95% CI: 0.18–0.66), dominant model (OR = 0.70; 95% CI: 0.52–0.94), homozygote model (OR = 0.32; 95% CI: 0.16–0.62), heterozygote model (OR = 0.37; 95% CI: 0.19–0.74), allelic model (OR = 0.67; 95% CI: 0.52–0.85). Conclusion: The minor allele of rs2910164 may increase the risk of T2DM by leading to lower level of miR-146a. In contrast, minor allele of rs895819 may decrease the risk of T2DM by leading to higher level of miR-27a.

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Section: Resultsmentioning

confidence: 99%

Association of microRNA gene polymorphisms with Type 2 diabetes mellitus: A systematic review and meta-analysis

et al. 2020

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“…These results were agreed with Mohsen et al, who stated that hyperglycemia induces miRNA-499 downregulation and explained their results with increased oxidative stress. They added that miRNA-499 downregulation mediated diabetic cardiomyopathy 29 . Also, Chavali et al, reported down regulation of miRNA-499 in diabetic hearts, suggesting miRNA-499 as a putative candidate implicated in the pathophysiology of diabetic heart disease 30 .…”

Section: Sensitivitymentioning

confidence: 99%

MicroRNA-499 Gene Expression in Egyptian Type 2 Diabetes Mellitus Patients with and without Coronary Heart Disease.

Oraby

Elshaer

Rashed

et al. 2021

Azhar International Journal of Pharmaceutical and Medical Scien

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Type 2 diabetes mellitus (T2DM) is a cumulative lifelong disease with long term dangerous cardiovascular complications. MicroRNA-499 (miRNA-499) is a muscle-specific miRNA highly expressed in normal heart. This case control study was designed to assess serum levels of miRNA-499 gene expression in Egyptian T2DM patients in comparison with normal healthy volunteers and to explore its relationship with its coronary heart disease (CHD) complication. This study was performed on 180 individuals enrolled from Kasr Al-Ainy Hospital. They were divided into three groups; 60 T2DM patients with CHD, 60 T2DM patients without any complication and 60 healthy volunteers. Fasting blood glucose, HbA1c and lipid profile were assessed. Quantitative Real Time PCR was used for evaluation of miRNA-499 gene expression. Receiver Operating Characteristics (ROC) curve of miRNA-499 serum gene expression was performed to study the ability of miRNA-499 gene expression to discriminate between the studied groups. MiRNA-499 gene expression was downregulated in both diabetic groups (p>0.001**) than the control group and in diabetic group with CHD complication than diabetic group without complications (p > 0.05**). ROC curve revealed that miRNA-499 gene expression discriminated between diabetic patients and controls with sensitivity 90% and specificity 96.6%. MiRNA-499 gene expression discriminated also between diabetic patients with and without CHD complication with sensitivity 73% and specificity 70%. MiRNA-499 downregulation was related to T2DM and its CHD complication risks. Collectively, miRNA-499 could be a beneficial biomarker for T2DM and its CHD complication and could discriminate between diabetic patients with and without CHD complication and normal individuals.

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“…It has been well known that T2D is the world's leading cause of motility and morbidity (Ali et al, 2022; Danaeifar, 2022). In addition, this metabolic disease can lead to the failure of different organs, especially the heart, nerves, eyes, kidneys, and blood vessels (Ali et al, 2022; Demir et al, 2021; Mohsen et al, 2022). Obesity, a sedentary lifestyle, energy‐dense diets, and aging are the most important risk factors for the occurrence or development of NCDs, especially T2D (Azadnajafabad et al, 2021; Pillon et al, 2021; Sharin et al, 2021; Storz, 2020).…”

Section: Introductionmentioning

confidence: 99%

Effect of sesame (Sesamum indicum L.) consumption on glycemic control in patients with type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials

Ramírez‐Coronel

Alhilali

Ahmed

et al. 2023

Phytotherapy Research

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Conflicting evidence exists on the effect of sesame consumption on glucose metabolism in patients with type 2 diabetes (T2D). Therefore, this meta‐analysis focuses on the relationship between sesame (Sesamum indicum L.) intervention and glycemic control in patients with T2D. Published literature was retrieved and screened from PubMed, Scopus, ISI Web of Science, and the Cochrane Library up to December 2022. Outcome measures included fasting blood sugar (FBS) concentrations, fasting insulin levels, and hemoglobin A1c (HbA1c) percentage. Pooled effect sizes were reported as weighted mean differences (WMDs) and 95% confidence intervals (CIs). Eight clinical trials (395 participants) were eligible for meta‐analyses. Overall, sesame consumption significantly reduced serum FBS (WMD: −28.61 mg/dL, 95% CI: −36.07 to −21.16, p˂0.001; I2 = 98.3%) and HbA1c percentage (WMD: −0.99%, 95% CI: −1.22 to −0.76, p ≤ 0.001; I2 = 65.1%) in patients with T2D. However, sesame consumption did not significantly influence fasting insulin levels (Hedges's: 2.29, 95% CI: −0.06 to 4.63, p = 0.06; I2 = 98.1%). In summary, the current meta‐analysis showed a promising effect of sesame consumption on glycemic control through reducing FBS and HbA1c, yet additional prospective studies are recommended, using higher doses and longer intervention period, to confirm the impact of sesame consumption on insulin levels in T2D patients.

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Association of mir-499 gene polymorphism with some hormones in type 2 diabetes mellitus patients

Cited by 4 publications

References 0 publications

Association of microRNA gene polymorphisms with Type 2 diabetes mellitus: A systematic review and meta-analysis

Association of microRNA gene polymorphisms with Type 2 diabetes mellitus: A systematic review and meta-analysis

MicroRNA-499 Gene Expression in Egyptian Type 2 Diabetes Mellitus Patients with and without Coronary Heart Disease.

Effect of sesame (Sesamum indicum L.) consumption on glycemic control in patients with type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials

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