Association of MMP-9 gene polymorphisms with atrial fibrillation in hypertensive heart disease patients

Gai, Xiaowu; Lan, Xiaopeng; Luo, Zhen; Wang, Feifei; Liang, Yingping; Zhang, Hueimin; Zhang, Wenli; Hou, Jianping; Huang, Mingfang

doi:10.1016/j.cca.2009.07.020

Cited by 24 publications

(21 citation statements)

References 30 publications

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“…Lacchini et al (2010) did not find any statistically significant difference in terms of total cholesterol, age and triglyceride, while a difference was seen in HDL, LDL, systolic and diastolic blood pressure, and body mass index in hypertensive patients compared to control. Gai et al (2009) reported that in terms of smoking, gender distribution, diabetes, systolic and diastolic blood pressure there was no statistically significant difference.…”

Section: Discussionmentioning

confidence: 95%

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Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

et al. 2013

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The current study was conducted to determine whether there is a relation between hypertension and two different polymorphisms, including C1562T of the Matrix metalloproteinase-9 (MMP-9) gene and C677T of the methylenetetrahydrofolate reductase (MTHFR) gene. Genomic DNA obtained from 224 persons (125 patients with hypertension and 99 healthy controls) were used in the study. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism and electrophoresis. The results were statistically analyzed and were found to be statistically significant. The frequencies of the C1562T genotypes were found to be, in controls CC 75.8 % and CT 24.2 % and in patients CC 71.2 %, and CT 28.8 %. The frequencies of C677T genotype were found to be, in controls CC 56.6 %, CT 38.4 and TT 5.1 % in controls and in patients CC 52 %, CT 30.4 % and TT 17.6 %. In conclusion, we may suggest that there is no relation between the essential hypertension and C1562T polymorphism of MMP-9 gene; on the other hand C677T polymorphism (genotype TT) of MTHFR gene can be regarded as a genetic indicator for the development of essential hypertension.

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Section: Discussionmentioning

confidence: 95%

“…The authors suggested that there is a remarkable relation between Chinese hypertensive heart disease patient population and C1562T polymorphism of the MMP-9 gene (Gai et al 2009). …”

Section: Discussionmentioning

confidence: 99%

Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

et al. 2013

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“…Associations between the rs3918242 polymorphism and higher circulating concentrations of the protein have previously been reported (Blankenberg et al, 2003;Yasmin et al, 2006;Gai et al, 2009;Wu et al, 2010). Overexpression of MMP-9 was found in human atherosclerotic plaques and involved in the rupture of the plaques (Brown et al, 1995).…”

Section: Figmentioning

confidence: 99%

Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in the Chinese Han Population: A Case–Control Study

Bai

Chen

et al. 2013

Genetic Testing and Molecular Biomarkers

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Objective: Matrix metalloproteinase-9 (MMP-9) plays an important role in inflammation and matrix degradation involved in atherosclerosis and plaque rupture. The T allele of rs3918242 has been reported to lead to a high promoter activity and associate with the extent of coronary artery disease (CAD). And some studies have reported that the G allele of rs17576 might be associated with CAD. The aim of this study was to assess the association between the polymorphisms of the MMP-9 gene and CAD in the Chinese Han population. Methods: This case-control study comprised 258 CAD cases and 153 controls from the Chinese Han Population. The genomic DNA of MMP-9 was isolated from whole blood. Polymerase chain reaction-based restriction fragment length polymorphism was used to determine the rs3918242 and rs17576 genotypes in the MMP-9 gene and the total serum levels of MMP-9 were measured using enzyme-linked immunosorbent assay in both case and control groups. Results: Analysis of MMP-9 gene polymorphisms showed that the frequencies of the T allele and CT + TT genotypes of rs3918242 were significantly higher in the case group than in the control group ( p < 0.05). However, the distribution of variant genotypes of rs17576 did not differ between the case and control groups ( p > 0.05). The total serum level of MMP-9 was significantly higher in the case group than in the control group ( p < 0.05). The subjects carrying T alleles in the CAD group had higher average serum MMP-9 levels compared with CC genotypes ( p < 0.05). Conclusions: Our results suggest that the single-nucleotide polymorphism of rs3918242 in the MMP-9 gene is associated with CAD and high serum levels of MMP-9 are also associated with CAD in the Chinese Han population. Therefore, genetic variation of rs3918242 may participate in the development of CAD through influencing MMP-9 expression.

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“…The polymorphism at position-1562 caused by a single base change C → T results in the loss of binding of a nuclear protein to this region of the MMP-9 gene promoter and increased transcriptional activity [25]. The T allele was associated with higher blood pressure and arterial stiffness in hypertensives [17].…”

Section: C1562t and R279q Variants Of Mmp-9 Genementioning

confidence: 89%

“…The T allele was associated with higher blood pressure and arterial stiffness in hypertensives [17]. This polymorphism (rs3918242) was also studied in relation with AF, CAD and CVD [25][26][27]. Another polymorphism R279Q (rs17576) of MMP-9 gene located at exon 6, is A to G substitution that results in change in amino acid arginine (R) to glutamine (Q) which lowers the catalytic domain activity of the enzyme [25].…”

Section: C1562t and R279q Variants Of Mmp-9 Genementioning

confidence: 99%

Association of MMP-1, 9, 12 and TIMP-1 gene polymorphisms in Malaysian male hypertensive subjects

Aalam¹,

Ramachandran²,

Heidari³

et al. 2018

biomedicalresearch

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Association of MMP-9 gene polymorphisms with atrial fibrillation in hypertensive heart disease patients

Cited by 24 publications

References 30 publications

Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in the Chinese Han Population: A Case–Control Study

Association of MMP-1, 9, 12 and TIMP-1 gene polymorphisms in Malaysian male hypertensive subjects

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