Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children

Angelova, Sirma; Salim, Ayshe; Kiselova-Kaneva, Yoana; Ivanova, Diana; Peev, Stefan

doi:10.3390/molecules25010085

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…The use of analysis from dipstick urinalysis is insufficient to show the state of individual reactivity to pathological processes of the excretory system. Dipstick urinalysis, as a conventional diagnostic method, is often associated with false positive and false negative results, so in determining the pathological process, it is necessary to carry out other diagnostic tests (Angelova et al, 2019).…”

Section: (B) Pielonefritismentioning

confidence: 99%

Saliva as Diagnostic Medium to Detect Infectious Disease in Human Body: A Review

Arinawati¹,

Novianti²

2022

Proceedings of the International Conference on Sustainable Innovation on Health Sciences and Nursing (ICOSI-HSN 2022)

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Saliva is a oral biological fluid that has many benefits and has an function for maintaining oral health and can be clinically informative as a diagnostic media. Biomarkers in saliva are molecules that contain certain ingredients can be used to diagnose disease or assess the development and outcome of treatment. The characteristics of biomarkers make it feasible to be an alternative diagnostic media. The latest emerging technology has revealed medically that salivary biomarkers are important for detection many disease conditions such as cancer, viruses, bacteria, cardiac disease, autoimmune and metabolism disturbance. The purpose of this study is to determine the role of saliva as a diagnostic medium through its various biomarkers in saliva that can detect diseases caused by viral, bacterial and fungal infections in the body. This literature review of PubMed database was conducted without any limitation on date of publication to identify the potential of saliva as diagnostic medium of infectious diseases. Saliva has potential as medium diagnostic for ZIKA virus in the early week of symptom onset. High level of IgG can be detected in saliva of Helicobacter pylori bacterial infection in the body. Changes in salivary proteins such as calprotectin and histatin also have important diagnostic values in the detection of fungal infections. It can be concluded that saliva has potential as diagnostic medium that can be used in detecting various diseases caused by viral, bacterial and fungal infections.

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Section: (B) Pielonefritismentioning

confidence: 99%

Saliva as Diagnostic Medium to Detect Infectious Disease in Human Body: A Review

Arinawati¹,

Novianti²

2022

Proceedings of the International Conference on Sustainable Innovation on Health Sciences and Nursing (ICOSI-HSN 2022)

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“… 100 Angelova and colleagues detected the salivary mRNA levels of IL-6, MMP-8, and GSS in 28 pyelonephritis children, and demonstrated 64, 3.27, and 1.94 times increase, respectively. 101 Fan et al revealed reduced expression of salivary PARK2 in manganese-exposed smelting workers, which may partly explain the manganese-induced Parkinsonian disorder. 102 Furthermore, the possibility to use those altered mRNA expressions in saliva as biomarkers for disease diagnosis deserves verification in a larger independent population.…”

Section: Introductionmentioning

confidence: 99%

Promising applications of human-derived saliva biomarker testing in clinical diagnostics

et al. 2023

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Saliva testing is a vital method for clinical applications, for its noninvasive features, richness in substances, and the huge amount. Due to its direct anatomical connection with oral, digestive, and endocrine systems, clinical usage of saliva testing for these diseases is promising. Furthermore, for other diseases that seeming to have no correlations with saliva, such as neurodegenerative diseases and psychological diseases, researchers also reckon saliva informative. Tremendous papers are being produced in this field. Updated summaries of recent literature give newcomers a shortcut to have a grasp of this topic. Here, we focused on recent research about saliva biomarkers that are derived from humans, not from other organisms. The review mostly addresses the proceedings from 2016 to 2022, to shed light on the promising usage of saliva testing in clinical diagnostics. We recap the recent advances following the category of different types of biomarkers, such as intracellular DNA, RNA, proteins and intercellular exosomes, cell-free DNA, to give a comprehensive impression of saliva biomarker testing.

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An Exploratory Study Demonstrating That Salivary Cytokine Profiles Are Altered in Children With Small Area Thermal Injury

Carlton

Voisey

Jones

et al. 2021

Journal of Burn Care &Amp; Research

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Serum can be used to investigate changes in cytokine concentration following burn injury in children, however for children receiving treatment in an outpatient setting, blood is not routinely collected and therefore cannot be used for monitoring. The aim of this study was to investigate the use of saliva as a non-invasive tool for predicting burn outcomes by measuring the concentration of salivary cytokines in children with small area burns. A multiplex cytokine assay was used to measure 17 cytokines in the saliva of paediatric patients with burns (n = 20) and healthy controls (n = 20). After the removal of cytokines that had >30% of samples below the assay lower detection limit, six cytokines including IL-1β, IL-4, IL-7, IL-8, MCP-1 and TNFα were analysed for association with burns. IL-1β and IL-4 were found to be significantly elevated in the paediatric burn patients compared to healthy controls. Interestingly, IL-1β was also significantly elevated in scald burns, compared to contact burns. In addition, biologically meaningful differences in cytokine concentration were identified in patients with different burn characteristics, which warrant further investigation. This exploratory study provides evidence that cytokines can be detected in the saliva of children and that salivary cytokine profiles differ between healthy controls and children with burns. Overall, this study demonstrates the value of saliva for the investigation of cytokines and its potential application in paediatric diagnostics, specifically in situations where blood collection is not appropriate.

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Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children

Cited by 4 publications

References 55 publications

Saliva as Diagnostic Medium to Detect Infectious Disease in Human Body: A Review

Saliva as Diagnostic Medium to Detect Infectious Disease in Human Body: A Review

Promising applications of human-derived saliva biomarker testing in clinical diagnostics

An Exploratory Study Demonstrating That Salivary Cytokine Profiles Are Altered in Children With Small Area Thermal Injury

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