Association of MTHFR and TNF-α genes polymorphisms with susceptibility to Legg-Calve-Perthes disease in Iranian children: A case-control study

Azarpira, Mohammad Reza; Ghilian, Mohammad Mahdi; Sobhan, Mohammad Reza; Mehdinezhad-Yazdi, Masoud; Aghili, Kazem; Miresmaeili, Seyed Mohsen; Neámatzadeh, Hossein

doi:10.1016/j.jor.2018.08.042

Cited by 28 publications

(23 citation statements)

References 20 publications

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“…TNF-α is a potential pro-inflammatory cytokine, which plays a critical role in a wide range of inflammatory, malignancies, and autoimmune diseases (10,11) . The TNF-α gene is located on chromosome 6p21.3, contains 8 exons, and encodes 382 amino acids (12,13) . The human TNF-α gene has close linkage with HLA class I and class II (8) .…”

Section: Association Of Tnf-α -308g>a Polymorphism With Susceptibilitmentioning

confidence: 99%

ASSOCIATION OF TNF- α-308G>A POLYMORPHISM WITH SUSCEPTIBILITY TO CELIAC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS

Aflatoonian

Moghimi

Akbarian-Bafghi

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: There is increasing evidence to show that TNF-α -308G>A polymorphism may be a risk factor for celiac disease, but the results are inconsistent. OBJECTIVE: Thus, we aimed to perform a meta-analysis involving published studies up to January 2019 to elucidate the association. METHODS: To assess the effect of TNF-α -308G>A polymorphism on celiac disease susceptibility, we searched PubMed, ISI Web of Knowledge, Chinese National Knowledge Infrastructure (CNKI) databases to identify eligible studies, without restriction. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to celiac disease. RESULTS: A total of 11 studies with 1147 cases and 1774 controls were selected for this meta-analysis. The pooled results indicated that TNF-α -308G>A polymorphism was associated with increased risk of celiac disease (A vs G: OR=2.077, 95% CI=1.468-2.939, P=≤0.001; AA vs GG: OR=8.512, 95% CI=3.740-19.373, P=≤0.001; AA+AG vs GG: OR=1.869, 95% CI=1.161-3.008, P=0.010; and AA+AG vs GG: OR=4.773, 95% CI=3.181-7.162, P≤0.001). Subgroup analysis by ethnicity also revealed significant association in Caucasians. In addition, there was a significant association between TNF-α -308G>A polymorphism and celiac disease risk in Italy, Spain and PCR-FRLP group studies. CONCLUSION: Our meta-analysis suggests that the TNF-α -308G>A polymorphism plays an important role in celiac disease susceptibility. However, our results are still needed to strengthen by further studies in different ethnicities and larger sample sizes.

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Section: Association Of Tnf-α -308g>a Polymorphism With Susceptibilitmentioning

confidence: 99%

ASSOCIATION OF TNF- α-308G>A POLYMORPHISM WITH SUSCEPTIBILITY TO CELIAC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS

Aflatoonian

Moghimi

Akbarian-Bafghi

et al. 2019

Arq. Gastroenterol.

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“…Epidemiological studies had identified that Methylene tetrahydrofolate reductase (MTHFR) was a potential genetic marker of different malignancies (Yi et al, 2016;He and Shen, 2017). The human MTHFR gene is located on chromosome 1p36.3, consist of 11 exons and spans 2.2 kb of genomic DNA (Abedinzadeh et al, 2015;Azarpira et al, 2018). It is encodes the vital enzyme which plays a key role in the folate/homocysteine metabolic pathway and regulates the intracellular folate level for the synthesis and methylation of DNA (Azarpira et al, 2018;Kamali et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…The human MTHFR gene is located on chromosome 1p36.3, consist of 11 exons and spans 2.2 kb of genomic DNA (Abedinzadeh et al, 2015;Azarpira et al, 2018). It is encodes the vital enzyme which plays a key role in the folate/homocysteine metabolic pathway and regulates the intracellular folate level for the synthesis and methylation of DNA (Azarpira et al, 2018;Kamali et al, 2018). In humans, the MTHFR 677C>T (in exon 4) polymorphism has been heavily studied in different disease.…”

Section: Introductionmentioning

confidence: 99%

Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis

Karimi-Zarchi

Moghimi

Abbasi

et al. 2019

Asian Pac J Cancer Prev

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Background: Previous studies have evaluated the impact of MTHFR 677C>T polymorphism on susceptibility to ovarian and cervical cancers in women, but the conclusions are still controversial. To get a more precise evaluation of the association between MTHFR 677C>T polymorphism and risk of ovarian and cervical cancers, we performed a meta-analysis of the association of all eligible studies. Methods: A comprehensive search performed in PubMed, Google Scholar, CNKI, and Web of Science databases to identify the relevant studies up to October 15, 2018. The strength of the association was estimated by odds ratios (OR) with 95% confidence interval (CI). Results: A total of 27 case-control studies including eleven studies with 4990 cases 7730 controls on ovarian cancer and 16 studies with 4990 cases and 7730 controls on cervical cancer were selected. Pooled data revealed that the MTHFR 677C>T polymorphism not significantly associated with an increased risk of ovarian and cervical cancers under all five genetic models. However, stratified analysis by ethnicity showed that the MTHFR 677C>T polymorphism was significantly associated with risk of ovarian cancer in Asians. No publication bias was found in the current meta-analysis. Conclusions: The results of this meta-analysis proposes that the MTHFR 677C>T polymorphism may not play a role in development of ovarian and cervical cancers in overall population. Further well-designed studies are necessary to clarify the precise role of the MTHFR 677C>T polymorphism on ovarian and cervical cancers risk.

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“…In past decades, apart from genetic variations that have raised major concerns in cancer bio logy, the role of inflammation factors such as tumour necrosis factor-alpha (TNF-α) has been widely researched in the aetiology of cancer [10,11]. The human TNF-α gene located on chromosome 6p21.3 contains 8 exons and encodes 382 amino acid proteins, in which -308G>A and -238 G>A are the most common polymorphisms [12,13]. TNF-α is a potential pro-inflammatory cytokine, which plays a critical role in a wide range of inflammatory, autoimmune and malignant diseases.…”

Section: Introductionmentioning

confidence: 99%

Association of TNF-α -308G>A Polymorphism with Susceptibility to Cervical Cancer and Breast Cancer – a Systematic Review and Meta-analysis

Farbod¹,

Karimi²,

Seifi³

et al. 2019

Klin Onkol

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Background: To date, several studies have been carried out on the association of TNF-α-308G>A with the risk of cervical cancer (CC) and breast cancer (BC). However, their conclusions were not consistent. Thus, we performed a comprehensive meta-analysis to evaluate the association more precisely from all eligible case-control studies. Methods: We searched the PubMed, Google Scholar and Cochrane Library databases systematically to identify relevant studies up to 1 February 2019. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using a fixed-or random-effects model. Results: A total of 40 case-control studies including 20 studies with 4,780 cases and 4,620 controls on CC and 20 studies with 12,390 cases and 14,910 controls on BC were selected in this meta-analysis. The pooled results showed that the TNF-α-308G>A polymorphism was significantly associated with an increased risk of CC (A vs.

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Association of MTHFR and TNF-α genes polymorphisms with susceptibility to Legg-Calve-Perthes disease in Iranian children: A case-control study

Abstract: Our case-control study failed to determine any association of MTHFR (677C > T and 1298A > C) and TNF-α (-308G > A and -238G > A) polymorphisms with LCPD risk. More studies with larger sample size are warranted to validate our findings.

Cited by 28 publications

References 20 publications

ASSOCIATION OF TNF- α-308G>A POLYMORPHISM WITH SUSCEPTIBILITY TO CELIAC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS

ASSOCIATION OF TNF- α-308G>A POLYMORPHISM WITH SUSCEPTIBILITY TO CELIAC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS

Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis

Association of TNF-α -308G>A Polymorphism with Susceptibility to Cervical Cancer and Breast Cancer – a Systematic Review and Meta-analysis

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