Association of Multidrug Resistant Pulmonary Tuberculosis and Diabetes Mellitus

Abstract

BACKGROUNDMultidrug Resistant Tuberculosis is a form of tuberculosis, which is caused by resistance for rifampicin and/or isoniazid. Diabetes increases the chances of emergence of resistance in tuberculosis patients. So, the aim of this study is to evaluate the association of diabetes mellitus in the emergence of resistance in tuberculosis patients. Aims and Objectives-To study the association of multidrug resistant pulmonary tuberculosis and diabetes mellitus. MATERIALS AND METHODS218 patients of pulmonary tuberculosis taken in this study who presented to SRN Hospital, over a period of one year from September 2016 to August 2017. Patients were investigated for FBS, PPBS and A1c and Gene-Xpert test was done to find drug resistance among tubercular patients. Study Design-A cross-sectional observational study. RESULTSOut of 218 patients, 108 were of MDR-TB and 110 were of drug sensitive TB on the basis of Gene-Xpert test. That means, 49.5% were of MDR-TB and 50.5% were drug sensitive TB. Out of 108 patients of MDR-TB, 33 (30.60%) were diabetic and among 110 patients of drug sensitive TB, 19 (17.03%) were diabetic. After using Chi-square test, p value was found to be 0.0210 which was statistically significant. CONCLUSIONPrevalence of diabetes mellitus was higher in patients suffering from tuberculosis and even greater in patients of multi-drug resistant pulmonary tuberculosis, so it can be concluded that diabetes mellitus may be one of the risk factors for emergence of resistance in the patients having pulmonary tuberculosis.