Association of myocardial viability on nitrate-augmented technetium-99m hexakis-2-methoxylisobutyl isonitrile myocardial tomography and intermediate-term outcome in patients with prior myocardial infarction and left ventricular dysfunction

Quantity of viable myocardium required to improve survival with revascularization in patients with ischemic cardiomyopathy: A meta-analysis

“…[27][28][29][30][31][32][33][34][35][36][37] The uptake of these flow tracers in SPECT imaging can show the preservation of resting myocardial perfusion in dysfunctional myocardium, and therefore, the presence of viability. Compared to FDG-PET studies which identify the specific area (perfusion-metabolism mismatch) in myocardium with preserved perfusion, a higher amount of viable myocardium may be needed to lead to improved survival with revascularization ( Figure 5).…”

The Effects of Medications on Myocardial Perfusion

“…In positron emission tomography (PET) studies, pre-treatment with nitrates increased tracer uptake in the ischemic myocardium compared with that in the nonviable myocardium, resulting in improved viability detection (31,32). Pre-treatment with nitrates improved detection of viable myocardium and predicted post-revascularization recovery in different studies that used resting MPI with the technetium-labeled tracers (tetrofosmin, sestamibi) and with thallium-201 (33)(34)(35)(36)(37)(38)(39)(40). In patients with ischemic cardiomyopathy, the prognostic value of SPECT MPI after nitrate was comparable to that of PET imaging (40).…”

Incremental prognostic value of cardiac single-photon emission computed tomography after nitrate administration in patients with ischemic left ventricular dysfunction

“…Other studies reported on the prognostic value of nitrate-augmented myocardial perfusion imaging. 20,21 In patients with ischemic cardiomyopathy and heart failure, Senior et al 20 demonstrated that myocardial viability, as determined by nitrate-enhanced thallium-201 and sestamibi, is equivalent for predicting functional improvements, remodeling, and survival after revascularization. He et al 21 demonstrated that nitrate-augmented myocardial sestamibi uptake may predict improved event-free survival in patients with ischemic LV dysfunction undergoing coronary revascularization.…”