Association of myostatin gene (MSTN) polymorphism with economic traits in rabbits

Bindu, K. A.; Raveendran, Arun; Antony, Siby; Raghunandanan, K. V.

doi:10.3920/978-90-8686-727-1_16

Cited by 7 publications

(10 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These frequencies are similar to those found in this study. However, the T and C allele frequencies were reported at 0.38 and 0.62, respectively, in Polish and White Flemish Giants Rabbits (Markowska et al, 2010) and 0.43 and 0.57 in a pooled population of New Zealand White and Soviet Chinchilla and their crosses (Bindu et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…Rabbits exhibit several traits of economic importance, including a high rate of reproduction, early maturity, high growth rate and efficient feed utilisation (Bindu et al, 2012). Due to these facts, we considered the rabbit MSTN gene as a candidate target gene to analyse for any correlations to meat production traits and, therefore, single nucleotide polymorphisms (SNPs) in the MSTN gene were studied.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit

2016

View full text Add to dashboard Cite

The Myostatin (MSTN), or Growth and Differentiation Factor 8 (GDF8), gene has been implicated in the double muscling phenomenon, in which a series of mutations render the gene inactive and unable to properly regulate muscle fibre deposition. Single nucleotide polymorphisms (SNPs) in the MSTN gene have been correlated to production traits, making it a candidate target gene to enhance livestock and fowl productivity. This study aimed to assess any association of three SNPs in the rabbit MSTN gene (c.713T>A in exon 2, c.747+34C>T in intron 2, and c.*194A>G in 3'-untranslated region) and their combinations, with carcass, production and reproductive traits. The investigated traits included individual body weight, daily body weight gain, carcass traits and reproductive traits. The 3 SNPs were screened using PCR-restriction fragment length polymorphism (RFLP)-based analysis and the effects of the different SNP genotypes and their combinations were estimated in a rabbit population. Additionally, additive and dominance effects were estimated for significant traits. The results found no significant association between the c.713 T>A SNP and all the examined traits. Allele T at the c.747+34C>T SNP was only significantly associated (P<0.05) with increased body weight at 12 wk of age. However, for the SNP residing in the 3' untranslated region (c.*194A>G), allele G was significantly associated (P<0.05) with increased body weight and high growth rate. Genotype GG at the c.*194A>G SNP also had positive effects on most carcass traits. The estimated additive genetic effect for the c.*194A>G SNP was significant (P<0.05) with most body weight, daily gain and carcass traits. No significant association was obtained between any MSTN SNPs and reproductive traits. In the combinations analysis, regardless of the genotypes of SNPs at c.713T>A and c.747+34C>T, GG at the c.*194A>G SNP correlated with highest values in body weight and daily weight gain. In conclusion, the 'G' allele at the c.*194A>G SNP had positive effects on growth and carcass traits and so could be used as a favourable allele in planning rabbit selection. Further population-wide studies are necessary to test the association of the c.*194A>G SNP with carcass traits. We also recommend evaluation of the potential effects of the c.*194A>G SNP on MSTN gene expression.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit

2016

View full text Add to dashboard Cite

show abstract

“…The genetic polymorphisms in loci encoding growth hormone and myostatin have so far been described in several livestock species, but only few studies have investigated their variability in the rabbit genome. Based [6][7][8][9][10]3] Also, the GH and MSTN the gene polymorphisms and their association with different performance traits were successfully determined in Oryctolaguscuniculus [11][12][13][14][15]. The present study was focused on identification of the polymorphisms at GH and MSTN genes in rabbits from the New Zealand White breed, reared in Bulgaria and on establishment of the genetic structure of their populations, by means of PCR-RFLP analysis.…”

Section: Introductionmentioning

confidence: 99%

Rabbit Growth Hormone and Myostatin Gene Polymorphisms

Hristova¹

2017

OAJAR

View full text Add to dashboard Cite

show abstract

“…HRM curve data were analyzed using the Precision Melt Analysis™ software (Martino et al, 2010). Allele frequencies, genotype frequencies, heterozygosity (He), effective number of alleles (Ne) and Polymorphic Information Content (PIC) were estimated based on the study of previously described (Bindu et al, 2012). The effects of genotype on the traits were analyzed by the general linear model (GLM) procedure of SAS 9.2 program according to the following statistical model:

Y_{ijk} = μ + G_{i} + S_{j} + B_{k} + e_{ijk}

…”

Section: Methodsmentioning

confidence: 99%

Rapid Genotyping of <italic>MSTN</italic> Gene Polymorphism Using High-resolution Melting for Association Study in Rabbits

Peng

Zhang

et al. 2013

Asian Australas. J. Anim. Sci

View full text Add to dashboard Cite

The myostatin (MSTN) gene, as a negative regulator of skeletal muscle growth, has been proposed to be associated with production traits in farm animals. In the present study, a T/C variant at −125 bp (relative to ATG start codon) of 5’regulatory region of rabbit MSTN was identified by direct sequencing. Two hundred and twenty two rabbits, which were randomly sampled from 3 breeds (Ira rabbits, Champagne rabbits and Tianfu black rabbits), were genotyped by high-resolution melting (HRM). Comparing the genotyping results of 47 samples with direct sequencing, the HRM showed high sensitivity (0.96) and high specificity (0.98). In the three rabbit breeds, the allele C was the predominant allele. The polymorphic site showed high heterozygosity (He = 0.48) and high effective number of alleles (Ne = 1.91). The genetic diversity was reasonably informative (0.25

show abstract

Association of myostatin gene (MSTN) polymorphism with economic traits in rabbits

Cited by 7 publications

References 3 publications

Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit

Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit

Rabbit Growth Hormone and Myostatin Gene Polymorphisms

Rapid Genotyping of <italic>MSTN</italic> Gene Polymorphism Using High-resolution Melting for Association Study in Rabbits

Contact Info

Product

Resources

About

Association of myostatin gene (MSTN) polymorphism with economic traits in rabbits

Cited by 7 publications

References 3 publications

Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit

Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit

Rabbit Growth Hormone and Myostatin Gene Polymorphisms

Rapid Genotyping of &lt;italic&gt;MSTN&lt;/italic&gt; Gene Polymorphism Using High-resolution Melting for Association Study in Rabbits

Contact Info

Product

Resources

About

Rapid Genotyping of <italic>MSTN</italic> Gene Polymorphism Using High-resolution Melting for Association Study in Rabbits