Association of Neutrophil to Lymphocyte Ratio With Presence and Severity of Gastritis Due to<i>Helicobacter pylori</i>Infection

Farah, Raymond; Khamisy‐Farah, Rola

doi:10.1002/jcla.21669

Cited by 58 publications

(70 citation statements)

References 17 publications

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“…Our study showed that an NLR cutoff value of 5.4 is significant in differentiating between cases of acute bacterial tonsillitis with DSNI and those without DNSI; this is similar to the value reported by previous studies in which NLR was used as an index in diagnosing H. pyroli associated gastritis, acute appendicitis, psoriasis and infective endocarditis [20][21][22][23]. Another expected finding was that the WBC count was also positively correlated with acute bacterial tonsillitis.…”

Section: Discussionsupporting

confidence: 87%

“…Sen et al studied 138 patients with psoriasis and stated that the NLR levels were also significantly higher in the psoriasis patients, and that the NLR levels increased with increase in the psoriasis area and severity index score [20]. Farah and Khamisy-Farah studied 50 patients with Helicobacter pylori infection and found a significant correlation between H. pyroli infection and inflammation on the basis of the NLR value; furthermore, NLR increased as the severity of gastritis associated with the infection increased [21]. With regard to NLR and infections, a recent study by İshizuka et al has also assessed its relationship with gangrenous appendicitis based on an analysis of 314 patients who had undergone open appendectomy; they found that NLR has a significant association with gangrenous appendicitis and disease severity in patients undergoing appendectomy [22].…”

Section: Discussionmentioning

confidence: 94%

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Predictive value of the neutrophil-to-lymphocyte ratio in patients with deep neck space infection secondary to acute bacterial tonsillitis

Bağlam

Binnetoğlu

Yumuşakhuylu

et al. 2015

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 94%

Predictive value of the neutrophil-to-lymphocyte ratio in patients with deep neck space infection secondary to acute bacterial tonsillitis

Bağlam

Binnetoğlu

Yumuşakhuylu

et al. 2015

International Journal of Pediatric Otorhinolaryngology

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“…Neutrophil:lymphocyte ratio (NLR), which has become one of the most popular biomarkers in biological and medical research in recent years, has been shown to correspond to numerous chronic inflammatory diseases (9,10). NLR is both accessible and affordable, and it thus has been increasingly used in clinical trials and research studies; however, few studies have examined the relationship between NLR and T2D (11), and whether NLR is associated with T2D is unknown.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study

Guo

Zhang

et al. 2015

European Journal of Endocrinology

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Aim: It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship between NLR and T2D. In order to evaluate how NLR is related to T2D, we designed a large-scale cross-sectional and prospective cohort study in an adult population. Subjects and methods: Participants were recruited from the Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (nZ87 686) and a prospective (nZ38 074) assessment were performed. Participants without a history of T2D were followed up for w6 years (with a median follow-up of 2.7 years). Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the quintiles of NLR and T2D (covariates: age, sex, BMI, smoking status, drinking status, hypertension, hyperlipidemia, and family history of cardiovascular disease, hypertension, hyperlipidemia, or diabetes). Results: The prevalence and incidence of T2D were 4.9% and 6.8/1000 person-years respectively. The adjusted odds ratio and hazard ratio (95% CI) of the highest NLR quintile were 1.34 (1.21, 1.49) and 1.39 (1.09, 1.78) (both P for trend !0.01) respectively as compared to the lowest quintile of NLR. Leukocyte, neutrophil, and lymphocyte counts do not significantly predict the eventual development of T2D. Conclusion: The present study demonstrates that NLR is related to the prevalence and incidence of T2D, and it suggests that NLR may be an efficient and accurate prognostic biomarker for T2D.

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“…Zahorec [7] has shown that there is a correlation between the severity of the clinical course of seriously ill patients and the degree of neutrophilia and lymphopenia. Recent studies have shown that NLR values are highly associated with the prognosis of diseases related to inflammation [8,9]. High NLR values have also been shown to be referring to the poor prognosis in different types of cancers [10,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Preoperative Neutrophil-to-Lymphocyte Ratio Has a Better Predictive Capacity in Diagnosing Tubo-Ovarian Abscess

Yıldırım¹,

Türkyılmaz²,

Avşar

2015

Gynecol Obstet Invest

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Background: The aim of this study is to identify the inflammatory markers which predict a tubo-ovarian abscess (TOA) in the most accurate way. Methods: This study involves 312 women. Preoperative inflammatory markers in the study group were compared with those in the healthy control group to identify the most efficient predictor of TOA with a high sensitivity and specificity. The recommended cutoff values of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), white blood cell count, and red cell distribution width were determined using receiver operating characteristic curve (ROC) analyses. Results: The area under the curve (AUC = 0.99) in the ROC analysis was found to be statistically significant for NLR (p < 0.001) with a cutoff value of ≥4.15 (95% CI 0.97-1.00, sensitivity 95.2%, specificity 99.4%). The positive predictive value of NLR was 99.2%, and the negative predictive value was 96.7% (p < 0.001). The recommended threshold for PLR was found to be 164.37 (AUC = 0.95, 95% CI 0.93-0.98, sensitivity 86.7%, specificity 92%), and the cutoff point of the white blood cell count in the ROC analysis was 9.55 × 10³/μl (AUC = 0.90, 95% CI 0.87-0.95, sensitivity 78.68%, specificity 96.68%). Conclusion: Preoperative NLR and PLR improve the predictive value of serum markers for the presence of TOA.

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Association of Neutrophil to Lymphocyte Ratio With Presence and Severity of Gastritis Due toHelicobacter pyloriInfection

Cited by 58 publications

References 17 publications

Predictive value of the neutrophil-to-lymphocyte ratio in patients with deep neck space infection secondary to acute bacterial tonsillitis

Predictive value of the neutrophil-to-lymphocyte ratio in patients with deep neck space infection secondary to acute bacterial tonsillitis

Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study

Preoperative Neutrophil-to-Lymphocyte Ratio Has a Better Predictive Capacity in Diagnosing Tubo-Ovarian Abscess

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