Association of occupational exposure with features of systemic sclerosis

Marie, I.; Ménard, Jean-François; Duval-Modeste, Anne-Bénédicte; Joly, P.; Dominique, S.; Bravard, P.; Noël, David; Gehanno, Jean-François; Bubenheim, Michael; Bénichou, Jacques; Lévesque, H.

doi:10.1016/j.jaad.2014.11.027

Cited by 46 publications

(34 citation statements)

References 31 publications

(23 reference statements)

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“…Freshly fractured particulate silica (crystalline silica, quartz) is released in gold mining, sandblasting, rock drilling, sand factory work, granite cutting, construction work, brick laying, sail tilling, cement work, and scouring powder factory work (Table 1) [2,4].…”

Section: Silicamentioning

confidence: 99%

“…Systemic sclerosis (SSc) is a systemic inflammatory disorder affecting the skin and other organs [1][2][3][4]. The condition is characterized by three histopathologic features: (i) both structural and functional vascular lesions, associated with progressive endothelial damage, reduction in the number of capillaries, thickening of arterial walls, and obliterative vasculopathy; (ii) perivascular and tissue infiltration of mononuclear inflammatory cells at early stages of SSc [5][6][7][8] (histological analyses of skin biopsy specimens have shown prominent CD4+ cellular infiltration with overexpression of cellular adhesion molecules in both vessels and interstitium); and (iii) increased synthesis and excessive deposition of extracellular matrix, resulting in fibrotic destruction of internal organs during the course of SSc [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Environmental risk factors of systemic sclerosis

Marie

Gehanno

2015

Semin Immunopathol

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Systemic sclerosis (SSc) has a complex pathogenesis. Although, there is a growing evidence that environmental factors have an impact on alterations and modulation of epigenetic determinants, resulting in SSc onset and progression. A marked correlation has thus been found between SSc onset and occupational exposure to crystalline silica and the following organic solvents: white spirit, aromatic solvents, chlorinated solvents, trichloroethylene, and ketones; the risk associated with high cumulative exposure to silica and organic solvents further appears to be strongly increased in SSc. Altogether, occupational exposure should be systematically checked in all SSc patients at diagnosis, as (1) exposed patients seem to develop more severe forms of SSc and (2) the identification of the occupational agents will allow its interruption, which may lead to potential improvement of SSc outcome. By contrast, based on current published data, there is insufficient evidence that exposure to other chemical agents (including notably pesticides as well as personal care such as silicone and hair dye), physical agents (ionizing radiation, ultraviolet radiation, electric and magnetic fields), and biological agents (infections and diet, foods, and dietary contaminants) is a causative factor of SSc. Further investigations are still warranted to identify other environmental factors that may be associated with SSc onset and progression.

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Section: Silicamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Environmental risk factors of systemic sclerosis

Marie

Gehanno

2015

Semin Immunopathol

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“…A prospective study has recently shown that occupational cases have the worst prognosis as compared to idiopathic ones. The exposure to crystalline silica/solvents is correlated with more severe forms of the SS characterized by diffuse cutaneous involvement, interstitial lung disease, general microangiopathy (digital ulcers and myocardial dysfunction), and association with cancer [8].…”

Section: Discussionmentioning

confidence: 99%

“…Malignant neoplasms may induce a wide variety of paraneoplastic rheumatological syndromes [21,22]. The opposite is also true, as it has been observed that scleroderma caused by the occupational exposure to solvents may frequently result in cancer [8]. Recent studies have suggested a model of paraneoplastic autoimmunity in which cross-reactive immune responses may target autoantigens expressed both in cancers and diseased autoimmune target tissues [23].…”

Section: Case Reportmentioning

confidence: 99%

Can scleroderma be induced by anesthetics? Case report

Magnavita¹

2016

Med Pr

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Occupational exposure to solvents is consistently associated with the risk of systemic sclerosis. We pose the question of whether the occupational exposure to anesthetics may favor the occurrence of this disease. This paper describes an incidence of systemic sclerosis in the case of an anesthesiologist who had been occupationally exposed to high doses of anesthetic in the operating room. Anecdotal cases in the literature give limited support to the causal association of the occupational exposure to anesthetics and systemic sclerosis. The extremely limited number of workers exposed makes it necessary to report all cases observed in order to assess the degree of the occupational risk for anesthesiologists. Med Pr 2016;67(4):557-560Key words: cancer, occupational exposure, operating room, anesthetics, solvent, solvent exposure Streszczenie Narażenie zawodowe na rozpuszczalniki jest związane z ryzykiem wystąpienia sklerodermii. Celem pracy było zbadanie, czy narażenie zawodowe na środki znieczulające również może wywołać tę chorobę. W artykule przedstawiono przypadek sklerodermii u lekarki anestezjologa, która była narażona na wysokie dawki środków znieczulających na sali operacyjnej. Opublikowane dotąd opisy przypadków nie pozwalają jednoznacznie powiązać narażenia zawodowego na środki znieczulające z wystąpieniem sklerodermii. Ze względu na niewielką liczbę pracowników narażonych na te środki powinny być raportowane wszystkie przypadki wystąpienia sklerodermii w celu określenia stopnia ryzyka zawodowego u anestezjologów. Med. Pr.

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“…Occupational exposure to crystalline silica/solvents is correlated with more severe forms of SSc, characterized by diffuse cutaneous involvement, interstitial lung disease, general microangiopathy (digital ulcers and myocardial dysfunction), and association with cancer) [3].…”

Section: Introductionmentioning

confidence: 99%

Incidence and prevalence of Systemic Sclerosis (SSc) in Poland – differences between rural and urban regions

Kanecki

Goryński

Tarka

et al. 2017

Ann Agric Environ Med.

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Kanecki K, Goryński P,Tarka P, WierzbaW, Tyszko P. Incidence and prevalence of Systemic Sclerosis (SSc) in Poland -differences between rural and urban regions. Ann Agric Environ Med. 2017; 24(2): 240-244. doi: 10.5604/12321966.1233570 Abstract Introduction. Systemic sclerosis (SSc) is a rare and potentially severe connective tissue disease, characterized by skin fibrosis and involvement of internal organs. Because of its rarity and heterogeneous clinical presentation, reliable epidemiological studies on SSc have been particularly difficult to carry out. Objectives. The purpose of this study was to present SSc epidemiology among hospitalized patients in Poland. Materials and method. The analysis was based on population-based administrative data, taken from a Polish hospital morbidity study carried out by the National Institute of Public Health between January 2008 -December 2012. Results. Analyzed data covered 9,049 hospitalization records. The final sample comprised 3,653 patients with first-time hospitalizations for SSc. The average age of the sample was 53 years (SD 16.2; range 0-91 years); 84% of patients were female and 16% male. Based on hospitalization registers, the average SSc incidence was estimated to be 1.9/100,000 per year and peak age of incidence was 55 years. The point prevalence was estimated to be 9.4/100,000 at the end of 2012. SSc was more common in females, with F:M ratio ranging from 6.2:1-4.6:1 depending on the year. Analysis of hospitalization trends revealed that overall numbers of SSc hospitalizations increased, while first-time hospitalizations decreased between 2008-2012. Clusters of higher incidence were observed in more rural regions vs. urban regions. Conclusion. Estimated incidence of SSc in Poland was comparable to reported incidence in other European countries. Analysis of demographic factors and reports of clusters of higher incidence may suggest the existence of environmental risk factors for the development of SSc. These observations may require further research.

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Association of occupational exposure with features of systemic sclerosis

Cited by 46 publications

References 31 publications

Environmental risk factors of systemic sclerosis

Environmental risk factors of systemic sclerosis

Can scleroderma be induced by anesthetics? Case report

Incidence and prevalence of Systemic Sclerosis (SSc) in Poland – differences between rural and urban regions

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