Association of ocular cataracts with inhaled and oral steroid therapy during long-term treatment of asthma

Toogood, J.H.; Markov, A E; Baskerville, J.; Dyson, Charles

doi:10.1016/0091-6749(93)90263-f

Cited by 98 publications

(55 citation statements)

References 45 publications

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“…The systemic side-effects of long-term treatment with high doses of inhaled glucocorticosteroids include easy bruising [61], adrenal suppression [62,63] and decreased bone mineral density [64,65]. Inhaled glucocorticosteroids have also been associated with cataracts [66] and glaucoma in cross-sectional studies [67,68], but there is no evidence of posterior-subcapsular cataracts in prospective studies [69][70][71].…”

Section: Asthma Controlmentioning

confidence: 99%

Global strategy for asthma management and prevention: GINA executive summary

Bateman

Ss²,

Barnes³

et al. 2007

Eur Respir J

2,664

2,301

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Asthma is a serious health problem throughout the world. During the past two decades, many scientific advances have improved our understanding of asthma and ability to manage and control it effectively. However, recommendations for asthma care need to be adapted to local conditions, resources and services. Since it was formed in 1993, the Global Initiative for Asthma, a network of individuals, organisations and public health officials, has played a leading role in disseminating information about the care of patients with asthma based on a process of continuous review of published scientific investigations. A comprehensive workshop report entitled ''A Global Strategy for Asthma Management and Prevention'', first published in 1995, has been widely adopted, translated and reproduced, and forms the basis for many national guidelines. The 2006 report contains important new themes. First, it asserts that ''it is reasonable to expect that in most patients with asthma, control of the disease can and should be achieved and maintained,'' and recommends a change in approach to asthma management, with asthma control, rather than asthma severity, being the focus of treatment decisions. The importance of the patient-care giver partnership and guided self-management, along with setting goals for treatment, are also emphasised.

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Section: Asthma Controlmentioning

confidence: 99%

Global strategy for asthma management and prevention: GINA executive summary

Bateman

Ss²,

Barnes³

et al. 2007

Eur Respir J

2,664

2,301

View full text Add to dashboard Cite

show abstract

“…[238][239][240] Furthermore, it has been suggested that infants not receive live vaccines during long-term corticosteroid therapy and that clinicians consider checking vaccine titers on completion of corticosteroid therapy to assess the adequacy of response. 237 Ocular adverse effects of long-term systemic corticosteroid therapy include cataracts 241,242 and increased intraocular pressure, [242][243][244][245] although neither has been frequently reported among children in general or among those being treated for IH in particular. The most serious ocular adverse effect is that of vision loss caused by embolic occlusion of the central retinal artery after intralesional injection.…”

Section: Adverse Effects Of Corticosteroid Therapymentioning

confidence: 99%

Diagnosis and Management of Infantile Hemangioma

Darrow¹,

Mancini²,

Nopper³

et al. 2015

Pediatrics

217

290

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Infantile hemangiomas (IHs) are the most common tumors of childhood. Unlike other tumors, they have the unique ability to involute after proliferation, often leading primary care providers to assume they will resolve without intervention or consequence. Unfortunately, a subset of IHs rapidly develop complications, resulting in pain, functional impairment, or permanent disfigurement. As a result, the primary clinician has the task of determining which lesions require early consultation with a specialist. Although several recent reviews have been published, this clinical report is the first based on input from individuals representing the many specialties involved in the treatment of IH. Its purpose is to update the pediatric community regarding recent discoveries in IH pathogenesis, treatment, and clinical associations and to provide a basis for clinical decision-making in the management of IH.

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“…14 In adults who received oral or high-dose inhaled glucocorticoids (or both), the prevalence of posterior subcapsular cataracts correlated with both the daily dose and the duration of oral glucocorticoid therapy, but not with the dose and duration of inhaled glucocorticoid therapy. 90 In a cross-sectional study of children taking inhaled beclomethasone or budesonide, no cataracts were found on slit-lamp examination, even in patients who had taken 2000 mg per day for more than 10 years. 91 …”

Section: Cataractsmentioning

confidence: 99%