Association of Omega-3 fatty acid and epileptic seizure in epileptic patients: A systematic review

Pourmasoumi, Makan; Vosoughi, Nooshin; Derakhshandeh-Rishehri, Seyedeh-Masomeh; Assarroudi, Mostafa; Heidari‐Beni, Motahar

doi:10.4103/ijpvm.ijpvm_281_16

Cited by 19 publications

(5 citation statements)

References 36 publications

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“…Evidence suggests that omega-3 PUFAs have anticancer activity, modulating cancer development by maintaining cell proliferation signals, inhibiting growth inhibitors and cell death, promoting angiogenesis, and reducing inflammation [ 85 ]. In genetic diseases such as epilepsy, although there are studies suggesting that omega-3 PUFAs may be beneficial, but the current research is insufficient to support this conclusion [ 86 , 87 ].…”

Section: Factors Associated With Omega-3 Pufa-microbiome-host Immumentioning

confidence: 99%

Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity

Wang

et al. 2021

Mediators of Inflammation

176

120

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Omega-3 polyunsaturated fatty acids (omega-3 PUFAs), which are essential fatty acids that humans should obtain from diet, have potential benefits for human health. In addition to altering the structure and function of cell membranes, omega-3 PUFAs (docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), alpha-linolenic acid (ALA), and docosapentaenoic acid (DPA)) exert different effects on intestinal immune tolerance and gut microbiota maintenance. Firstly, we review the effect of omega-3 PUFAs on gut microbiota. And the effects of omega-3 PUFAs on intestinal immunity and inflammation were described. Furthermore, the important roles of omega-3 PUFAs in maintaining the balance between gut immunity and the gut microbiota were discussed. Additional factors, such as obesity and diseases (NAFLD, gastrointestinal malignancies or cancer, bacterial and viral infections), which are associated with variability in omega-3 PUFA metabolism, can influence omega-3 PUFAs–microbiome–immune system interactions in the intestinal tract and also play roles in regulating gut immunity. This review identifies several pathways by which the microbiota modulates the gut immune system through omega-3 PUFAs. Omega-3 supplementation can be targeted to specific pathways to prevent and alleviate intestinal diseases, which may help researchers identify innovative diagnostic methods.

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Section: Factors Associated With Omega-3 Pufa-microbiome-host Immumentioning

confidence: 99%

Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity

Wang

et al. 2021

Mediators of Inflammation

176

120

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“…While DHA injection in mice lowers blood pressure (Hoshi et al, 2013b), the physiological roles of this fatty acid within the nervous system are not well defined. Injection of DHA in rats increased latency of PTZ-induced seizure implicating its neuroprotective effect ( (Trépanier et al, 2014)); however, a systemic review assessing protective role of omega-3 supplementation in human seizures reported inconclusive evidence of benefit (Pourmasoumi et al, 2018). Two patients with KCNMA1-linked channelopathy have been trialed on DHA (in combination with acetazolamide; Heim et al, 2019).…”

Section: Precision Medicine and Future Directionsmentioning

confidence: 99%

KCNMA1-linked channelopathy

Bailey

Moldenhauer

Park

et al. 2019

Journal of General Physiology

117

118

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KCNMA1 encodes the pore-forming α subunit of the “Big K+” (BK) large conductance calcium and voltage-activated K+ channel. BK channels are widely distributed across tissues, including both excitable and nonexcitable cells. Expression levels are highest in brain and muscle, where BK channels are critical regulators of neuronal excitability and muscle contractility. A global deletion in mouse (KCNMA1−/−) is viable but exhibits pathophysiology in many organ systems. Yet despite the important roles in animal models, the consequences of dysfunctional BK channels in humans are not well characterized. Here, we summarize 16 rare KCNMA1 mutations identified in 37 patients dating back to 2005, with an array of clinically defined pathological phenotypes collectively referred to as “KCNMA1-linked channelopathy.” These mutations encompass gain-of-function (GOF) and loss-of-function (LOF) alterations in BK channel activity, as well as several variants of unknown significance (VUS). Human KCNMA1 mutations are primarily associated with neurological conditions, including seizures, movement disorders, developmental delay, and intellectual disability. Due to the recent identification of additional patients, the spectrum of symptoms associated with KCNMA1 mutations has expanded but remains primarily defined by brain and muscle dysfunction. Emerging evidence suggests the functional BK channel alterations produced by different KCNMA1 alleles may associate with semi-distinct patient symptoms, such as paroxysmal nonkinesigenic dyskinesia (PNKD) with GOF and ataxia with LOF. However, due to the de novo origins for the majority of KCNMA1 mutations identified to date and the phenotypic variability exhibited by patients, additional evidence is required to establish causality in most cases. The symptomatic picture developing from patients with KCNMA1-linked channelopathy highlights the importance of better understanding the roles BK channels play in regulating cell excitability. Establishing causality between KCNMA1-linked BK channel dysfunction and specific patient symptoms may reveal new treatment approaches with the potential to increase therapeutic efficacy over current standard regimens.

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“…As well, GABA together with GAD and GABA transporters are highly expressed in different islets of Langerhans suggesting the potential role of GABA in pancreatic biology. [ 5 ]…”

Section: Methods and Search Strategymentioning

confidence: 99%

The potential role of pancreatic γ-aminobutyric acid (GABA) in diabetes mellitus: A critical reappraisal

Al-Kuraishy¹,

Hussian²,

Al-Naimi³

et al. 2021

Int J Prev Med

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Association of Omega-3 fatty acid and epileptic seizure in epileptic patients: A systematic review

Cited by 19 publications

References 36 publications

Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity

Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity

KCNMA1-linked channelopathy

The potential role of pancreatic γ-aminobutyric acid (GABA) in diabetes mellitus: A critical reappraisal

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