Association of oral contraceptive and metformin did not improve insulin resistance in women with polycystic ovary syndrome

Iwata, Margareth Chiharu; Porquere, Livia; Sorpreso, Isabel Cristina Espósito; Baracat, Edmund C.; Júnior, José Maria Soares

doi:10.1590/1806-9282.61.03.215

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…In an androgenized rat model, metformin demonstrates a significant impact on ovarian follicle dynamics by reducing the proliferation of theca cells and suppressing CYP-17 expression 14 . On the contrary, the combination of oral contraceptives and metformin did not improve insulin resistance in women with polycystic ovary syndrome 15 . The combination of metformin and lifestyle changes has the potential to boost the number of menstrual cycles in individuals with polycystic ovary syndrome 16 .…”

Section: Discussionmentioning

confidence: 78%

Effect of a combination of gliptin and metformin on serum vitamin B12, folic acid, and ferritin levels

Genc,

Nalbant,

Genc

et al. 2023

Rev. Assoc. Med. Bras.

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OBJECTIVE:The primary objective of this study was to explore the impact of metformin and metformin/gliptin combination therapy on the serum concentrations of vitamin B12, ferritin, and folic acid in individuals diagnosed with type 2 diabetes. METHODS: This study included 118 patients, classified into two groups: 59 patients using only metformin and 59 patients using a combination of metformin/gliptin. Among the latter group, 35 patients used vildagliptin/metformin, and 24 used sitagliptin/metformin. The study recorded the demographic data such as the age and gender of the patients, as well as their initial and 1-year follow-up blood parameters. RESULTS: Folic acid decreased significantly in the metformin group but not in the metformin/gliptin group. Vitamin B12 and ferritin decreased significantly in both groups. The decrease in vitamin B12 and ferritin was not significantly different between the two groups. The decrease in fasting plasma glucose was more significant in the metformin/gliptin group than in the metformin group. CONCLUSION: After 1 year, both groups taking metformin and metformin/gliptin showed low serum ferritin and vitamin B12 levels. Therefore, vitamin B12 levels in patients using these drugs should be closely monitored. Ferritin levels can be used to indicate whether glycemic control has been achieved.

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Section: Discussionmentioning

confidence: 78%

Effect of a combination of gliptin and metformin on serum vitamin B12, folic acid, and ferritin levels

Genc,

Nalbant,

Genc

et al. 2023

Rev. Assoc. Med. Bras.

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“…Combined treatment with oral contraceptives and clomiphene citrate appears to improve the results when comparing the usage of any of these drugs alone; however, few studies validate this assertion. 17,20 Acupuncture has gained attention for treating insulin sensitivity, since this therapy certainly mediates the activation of sensory nerve fibers which regulates the sympathetic activity in the ovaries and in the central nervous system 18 . According to Balen et al 21 (2016) this therapy suppresses the secretion of cortisol in the adrenals, and modulates the secretion of beta-endorphin, influencing the release of GnRH, presupposing that acupuncture can acts in the anovulation resulted from PCOS.…”

Section: Discussionmentioning

confidence: 99%

Polycystic ovary syndrome therapeutic methods: A systematic review

Farinha¹,

Farinha²,

Silva³

et al. 2023

Braz. J. Hea. Rev.

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Polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine disorder, whose prevalence in women varies from 6 to 10% in the reproductive period. It can lead to health complications, such as menstrual dysfunction, infertility, hirsutism, acne and metabolic syndrome. The biggest difficulties with this syndrome is to recognize its etiopathogenesis and select the best therapy. This study is a systematic review, which carried out an electronic search in the following databases SCIELO, LILACS, PUBMED, selected 34 articles. The purpose of the review is: to understand the therapeutic methods available for treatment, although there is no cure for the syndrome, the aim of the approach is to minimize the clinical signs and improve the quality of life of these women. The first therapy to be used is the change in lifestyle and changes in the diet, in the background medications are applied. Treatment must be individualized according to the complaints of each patient.

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“…Como resultado, ocorre atresia folicular ovariana, ciclos anovulatórios e amenorreia, bem como efeitos da pele, incluindo hirsutismo e grave agravamento da acne (Iwata et al, 2015).…”

Section: Hiperinsulinemiaunclassified

Síndrome de ovários policísticos (SOP), fisiopatologia e tratamento, uma revisão

Alves

Donne²,

Romano³

et al. 2022

RSD

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A síndrome dos ovários policísticos é uma patologia de etiologia multifatorial e uma das principais causas de infertilidade feminina mundialmente. Além de alterações na fisiologia reprodutiva, como ciclos menstruais irregulares, anovulação, hiperandrogenismo e presença de múltiplos cistos no ovário, também ocorrem alterações metabólicas capazes de afetar a qualidade de vida e a sobrevida de mulheres portadoras da síndrome. O comprometimento endócrino atrelado à síndrome dos ovários policísticos ocorre devido ao desenvolvimento de síndrome metabólica, condição caracterizada por tolerância à glicose diminuída, dislipidemia e hipertensão. Contudo, a manifestação dos sintomas associados à síndrome dos ovários policísticos depende da interação entre fatores genéticos, epigenéticos, estilo de vida e hábitos alimentares. A inter-relação entre esses fatores resulta na diversidade fenotípica apresentada por mulheres portadoras da síndrome. Ou seja, as manifestações clínicas e a gravidade sintomática variam entre as mulheres portadoras, de forma que o tratamento é individualizado para cada paciente. O manejo terapêutico da síndrome é voltado ao alívio sintomático e indução da ovulação, uma vez que ainda não existe um tratamento curativo. Essa revisão narrativa objetiva evidenciar os principais aspectos clínicos, endócrinos e metabólicos da síndrome dos ovários policísticos, uma das principais causas de infertilidade feminina.

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Association of oral contraceptive and metformin did not improve insulin resistance in women with polycystic ovary syndrome

Abstract: AssociAtion of orAl contrAceptive And metformin did not improve insulin resistAnce in women with polycystic ovAry syndrome rev assoC Med bras 2015; 61(3):215-219 215

Cited by 11 publications

References 30 publications

Effect of a combination of gliptin and metformin on serum vitamin B12, folic acid, and ferritin levels

Effect of a combination of gliptin and metformin on serum vitamin B12, folic acid, and ferritin levels

Polycystic ovary syndrome therapeutic methods: A systematic review

Síndrome de ovários policísticos (SOP), fisiopatologia e tratamento, uma revisão

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