Association of oral HPV16 infection with periodontal inflammation and the oral microbiome in older women

Shigeishi, Hideo; Su, Cheng-Yih; Kaneyasu, Yoshino; Miyata, Mari; Nakamura, Mariko; Ishikawa, Masatoshi; Saito, Ayumi; Ohta, Kouji; Sugiyama, Masaru

doi:10.3892/etm.2020.9598

Cited by 16 publications

(15 citation statements)

References 29 publications

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“…Three mechanisms of action of these microbiota in the pathogenesis of oral cancer had been revealed: chronic inflammation, antiapoptotic activity, cancerogenic substances [24]. In addition, as one of the cause of cervical cancer, HPV is also a risk factor for oral cancer [27]. HPV16 and Prevotella were significantly more abundant in oral squamous cell carcinoma lesions as compared to the control tissue section [28].…”

Section: Discussionmentioning

confidence: 99%

The feature of cervical microbiota associated with the progression of cervical cancer among reproductive females

Ding

Kong

et al. 2021

Gynecologic Oncology

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Cervical species diversity was higher in severer cervical intraepithelial neoplasia of reproductive-age women.• women with severer cervical pathology had more complex composition of cervical microbiota and more anaerobic bacteria.• Porphyromonas and Campylobacter were newfound marker genera of cervical cancer.• The correlation of differential functional pathways with Prevotella was opposite to that with Lactobacillus.• Marker genera in the lesion progression will be helpful for diagnosis, prevention and treatment.

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Section: Discussionmentioning

confidence: 99%

The feature of cervical microbiota associated with the progression of cervical cancer among reproductive females

Ding

Kong

et al. 2021

Gynecologic Oncology

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“…Regarding periodontal disease and dental caries status, our sub-cohort is similar to that of the larger OraRad cohort ( Table 1 and Brennan et al, 2021 ). A study identified by LitSuggest, reviewing findings pertaining to oral HPV infection in relation to periodontitis, suggests periodontal pockets may act as a reservoir for HPV and that oral HPV prevalence may be associated with periodontitis ( Shigeishi et al, 2021a ). Another recent study characterizing HPV16 DNA prevalence and periodontal disease inflammation in a population of older Japanese women identified an increase of Prevotella intermedia and Porphyromonas and a decrease of Veillonella and Prevotella to be associated with periodontal disease inflammation ( Shigeishi et al, 2021b ).…”

Section: Discussionmentioning

confidence: 99%

“…Of 203 HPV microbiome articles, only 15 were verified as relevant to HPV and the oral microbiome in SCC. Only two studies identified by LitSuggest related oral SCC with HPV and periodontitis ( Chowdhry et al, 2019 ; Shigeishi et al, 2021a ). Furthermore, few studies investigated multiple primary tumor sites in SCC patients.…”

Section: Discussionmentioning

confidence: 99%

Haemophilus pittmaniae and Leptotrichia spp. Constitute a Multi-Marker Signature in a Cohort of Human Papillomavirus-Positive Head and Neck Cancer Patients

et al. 2022

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ObjectivesHuman papillomavirus (HPV) is a known etiological factor of oropharyngeal head and neck cancer (HNC). HPV positivity and periodontal disease have been associated with higher HNC risk, suggesting a role for oral bacterial species. Our objective was to determine oral microbiome profiles in HNC patients (HPV-positive and HPV-negative) and in healthy controls (HC).MethodsSaliva samples and swabs of buccal mucosa, supragingival plaque, and tongue were collected from HNC patients (N = 23 patients, n = 92 samples) before cancer therapy. Next-generation sequencing (16S-rRNA gene V3–V4 region) was used to determine bacterial taxa relative abundance (RA). β-Diversities of HNC HPV+ (N = 16 patients, n = 64 samples) and HNC HPV– (N = 7 patients, n = 28 samples) groups were compared using PERMANOVA (pMonte Carlo < 0.05). LEfSe discriminant analysis was performed to identify differentiating taxa (Log LDA > 2.0). RA differences were analyzed by Mann–Whitney U-test (α = 0.05). CombiROC program was used to determine multi-marker bacterial signatures. The Microbial Interaction Network Database (MIND) and LitSuggest online tools were used for complementary analyses.ResultsHNC vs. HC and HNC HPV+ vs. HNC HPV– β-diversities differed significantly (pMonte Carlo < 0.05). Streptococcus was the most abundant genus for HNC and HC groups, while Rothia mucilaginosa and Haemophilus parainfluenzae were the most abundant species in HNC and HC patients, respectively, regardless of antibiotics treatment. LEfSe analysis identified 43 and 44 distinctive species for HNC HPV+ and HNC HPV– groups, respectively. In HNC HPV+ group, 26 periodontal disease-associated species identified by LefSe had a higher average RA compared to HNC HPV– group. The significant species included Alloprevotella tannerae, Fusobacterium periodonticum, Haemophilus pittmaniae, Lachnoanaerobaulum orale, and Leptotrichia spp. (Mann–Whitney U-test, p < 0.05). Of 43 LEfSe-identified species in HPV+ group, 31 had a higher RA compared to HPV– group (Mann–Whitney U-test, p < 0.05). MIND analysis confirmed interactions between Haemophilus and Leptotrichia spp., representing a multi-marker signature per CombiROC analysis [area under the curve (AUC) > 0.9]. LitSuggest correctly classified 15 articles relevant to oral microbiome and HPV status.ConclusionOral microbiome profiles of HNC HPV+ and HNC HPV– patients differed significantly regarding periodontal-associated species. Our results suggest that oral bacterial species (e.g., Leptotrichia spp.), possessing unique niches and invasive properties, coexist with HPV within HPV-induced oral lesions in HNC patients. Further investigation into host–microbe interactions in HPV-positive HNC patients may shed light into cancer development.

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“…Others found correlation between HPV positivity in oropharyngeal cancer and severity of periodontitis measured by extent of alveolar bone loss [ 64 ], suggesting potential interaction between periodontal pathogens or resulting inflammation and HPV. However, other studies [ 65 , 66 , 67 ] that addressed altered prevalence or composition of oral/periodontal bacteria were too small (i.e., number of HPV positive cases < 10) to draw any reliable conclusion concerning specific bacteria to interact HPV.…”

Section: Head and Neck Cancermentioning

confidence: 99%

Bacterial-Viral Interactions in Human Orodigestive and Female Genital Tract Cancers: A Summary of Epidemiologic and Laboratory Evidence

Kato

Zhang

Sun

2022

Cancers

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Infectious agents, including viruses, bacteria, fungi, and parasites, have been linked to pathogenesis of human cancers, whereas viruses and bacteria account for more than 99% of infection associated cancers. The human microbiome consists of not only bacteria, but also viruses and fungi. The microbiome co-residing in specific anatomic niches may modulate oncologic potentials of infectious agents in carcinogenesis. In this review, we focused on interactions between viruses and bacteria for cancers arising from the orodigestive tract and the female genital tract. We examined the interactions of these two different biological entities in the context of human carcinogenesis in the following three fashions: (1) direct interactions, (2) indirect interactions, and (3) no interaction between the two groups, but both acting on the same host carcinogenic pathways, yielding synergistic or additive effects in human cancers, e.g., head and neck cancer, liver cancer, colon cancer, gastric cancer, and cervical cancer. We discuss the progress in the current literature and summarize the mechanisms of host-viral-bacterial interactions in various human cancers. Our goal was to evaluate existing evidence and identify gaps in the knowledge for future directions in infection and cancer.

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Association of oral HPV16 infection with periodontal inflammation and the oral microbiome in older women

Cited by 16 publications

References 29 publications

The feature of cervical microbiota associated with the progression of cervical cancer among reproductive females

The feature of cervical microbiota associated with the progression of cervical cancer among reproductive females

Haemophilus pittmaniae and Leptotrichia spp. Constitute a Multi-Marker Signature in a Cohort of Human Papillomavirus-Positive Head and Neck Cancer Patients

Bacterial-Viral Interactions in Human Orodigestive and Female Genital Tract Cancers: A Summary of Epidemiologic and Laboratory Evidence

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