Association of organic solvents and occupational noise on hearing loss and tinnitus among adults in the U.S., 1999–2004

Staudt, Amanda M; Whitworth, Kristina W.; Chien, Lung-Chang; Whitehead, Lawrence W.; Porras, David Gimeno Ruiz de

doi:10.1007/s00420-019-01419-2

Cited by 24 publications

(16 citation statements)

References 39 publications

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“…The generation of superoxide radical in the organ of Corti, spiral ganglion neurons, and stria vascularis and increased levels of 8-Isoprostane, a biomarker of lipid peroxidation, in the stria vascularis and spiral ganglion neurons have been reported after styrene exposure [32]. Exposure to BTEX (Benzene, Toluene, Ethylbenzene, and Xylene), a cocktail of highly soluble and volatile organic compounds naturally occurring in crude oil and petroleum products, is also a major risk factor for hearing loss [33,34], as ototoxic levels of BTEX can be present in both indoor and outdoor environments [35]. Emissions from motor vehicles, petrol stations, and refineries are major sources of BTEX in the outdoor environment.…”

Section: Ototoxic Chemicalsmentioning

confidence: 99%

Environmental Exposures and Hearing Loss

Rosati

Jamesdaniel

2020

IJERPH

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Pollutants that contaminate the natural or built environment adversely affect the health of living organisms. Although exposure to many of them could be avoided or minimized by careful preventive measures, it is impossible to totally avoid exposure to all pollutants. Ototraumatic agents, such as noise, chemicals, and heavy metals, are pervasive pollutants, mostly produced by human activity, and are critical factors in inducing acquired hearing loss. More importantly, exposure to these pollutants often occurs concurrently and, therefore, the synergistic interactions potentiate auditory dysfunction in susceptible individuals. Epidemiological studies have provided compelling data on the incidence of auditory dysfunction after exposure to a number of ototraumatic agents in the environment, while animal studies have offered crucial insights for understanding the underlying molecular mechanisms. Together, they provide a framework for developing effective interventional approaches for mitigating the adverse impacts of environmental or occupational exposure to ototraumatic agents. This article provides a brief overview of the common pollutants that cause hearing loss.

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Section: Ototoxic Chemicalsmentioning

confidence: 99%

Environmental Exposures and Hearing Loss

Rosati

Jamesdaniel

2020

IJERPH

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“…Several studies have documented the ototoxicity of the solvent mixture, noise plus solvent mixture, and toluene plus noise (Hsu et al, 2015;Lewkowski et al, 2019;Staudt et al, 2019, Hemmativaghef, 2020. A study found a significant association between organic solvent (toluene, benzene, and ethylbenzene) and high-frequency hearing loss whereby the estimated effect is higher than the audiometrically assessed (Staudt et al 2019).…”

Section: Literature Reviewmentioning

confidence: 99%

Solvent-Induced Hearing Loss from Occupational Exposure In Asia – A systematic review

Aris

Abidin

Razali

et al. 2021

E-BPJ

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Exposure to certain solvents in the workplace can cause hearing loss. This study aims to bring attention to the existing literature on the adverse effects of solvents on workers' auditory function in a diverse Asia occupational setting. The literature search used in this study is PubMed and Web of Science. 87% of the selected studies reported that the highest prevalence of hearing loss was from solvents plus noise-exposed group. Evidence shows that interaction between the solvent and the noise could be both additive and synergistic. More epidemiology studies on solvent-induced hearing loss using diverse approaches are warranted in Asia region. Keywords: hearing loss, organic solvent, pure tone audiometry, chemical-induced hearing loss eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI:

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“…Of interest with regard to the potential ototoxicity of styrene in the general population is a Ph. D. thesis project examining the relationship between exposure to styrene and other simple aromatic solvents (assessed via concentrations in blood from subjects aged 20-59 years measured in the NHANES 1999NHANES -2004 data sets) and hearing impairment assessed as self-reported hearing loss or tinnitus and audiometrically assessed hearing loss (pure tone threshold change greater than 25 dB in either ear) (Staudt 2016). The number of study participants was 2513 but the sample size varied with analysis as the available data for each of the studied solvents and outcomes was variable.…”

Section: Non-cancer Health Effectsmentioning

confidence: 99%

“…After adjustment for covariates, odds ratios for styrene were no longer elevated; those for benzene, toluene, and ethylbenzene and highfrequency hearing loss were elevated. As noted by the author, blood concentrations of volatile organic compounds (VOCs) are reflective of recent rather than chronic exposures, and thus are not an ideal exposure metric for a chronic health effect (Staudt 2016). However, when background exposure is constant, as it is with styrene and the other aromatics considered in the thesis, blood concentrations can provide an accurate representation of chronic exposure.…”

Section: Non-cancer Health Effectsmentioning

confidence: 99%

Evaluation of potential health effects associated with occupational and environmental exposure to styrene – an update

Banton

Bus

Collins

et al. 2019

Journal of Toxicology and Environmental Health, Part B

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The potential chronic health risks of occupational and environmental exposure to styrene were evaluated to update health hazard and exposure information developed since the Harvard Center for Risk Analysis risk assessment for styrene was performed in 2002. The updated hazard assessment of styrene's health effects indicates human cancers and ototoxicity remain potential concerns. However, mechanistic research on mouse lung tumors demonstrates these tumors are mouse-specific and of low relevance to human cancer risk. The updated toxicity database supports toxicity reference levels of 20 ppm (equates to 400 mg urinary metabolites mandelic acid + phenylglyoxylic acid/g creatinine) for worker inhalation exposure and 3.7 ppm and 2.5 mg/kg bw/day, respectively, for general population inhalation and oral exposure. No cancer risk value estimates are proposed given the established lack of relevance of mouse lung tumors and inconsistent epidemiology evidence. The updated exposure assessment supports inhalation and ingestion routes as important. The updated risk assessment found estimated risks within acceptable ranges for all age groups of the general population and workers with occupational exposures in non-fiber-reinforced polymer composites industries and fiber-reinforced polymer composites (FRP) workers using closedmold operations or open-mold operations with respiratory protection. Only FRP workers using open-mold operations not using respiratory protection have risk exceedances for styrene and should be considered for risk management measures. In addition, given the reported interaction of styrene exposure with noise, noise reduction to sustain levels below 85 dB(A) needs be in place.

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Association of organic solvents and occupational noise on hearing loss and tinnitus among adults in the U.S., 1999–2004

Cited by 24 publications

References 39 publications

Environmental Exposures and Hearing Loss

Environmental Exposures and Hearing Loss

Solvent-Induced Hearing Loss from Occupational Exposure In Asia – A systematic review

Evaluation of potential health effects associated with occupational and environmental exposure to styrene – an update

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