Association of outdoor air pollution, lifestyle, genetic factors with the risk of lung cancer: A prospective cohort study

Liang, Huaying; Zhou, Xin; Zhu, Yiqun; Li, Dianwu; Jing, Danrong; Su, Xiaoli; Pan, Pinhua; Liu, Hong; Zhang, Yan

doi:10.1016/j.envres.2022.114996

Cited by 28 publications

(16 citation statements)

References 56 publications

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“…6 The associations of genetic risk and lifestyle with risk of other major cancers, including cancers of thyroid, lung, stomach, pancreas, colorectum, ovarian, kidney, bladder, uterine, prostate, non-Hodgkin's lymphoma, lymphocytic leukemia, and melanoma, have been reported. [8][9][10][11][12][13][14] However, no such evidence has been reported for early-onset cancers.…”

Section: Discussionmentioning

confidence: 99%

“…These studies have focused on overall cancer 5 and a few major cancer types. [6][7][8][9][10][11][12][13][14] Early-onset cancer, defined as cancer diagnosed under age 50, represents a unique spectrum of malignancies 15,16 and generally manifests with a more aggressive disease phenotype. 15,16 The incidence of early-onset cancer has increased globally over the past decades, possibly supporting a basis in changing environmental hazards or interactions between hazardous environments and genetics.…”

Section: Introductionmentioning

confidence: 99%

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Genetic Risk, Health-Associated Lifestyle, and Risk of Early-onset Total Cancer and Breast Cancer

Zhang,

Lindström,

Kraft

et al. 2024

Preprint

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Importance Early-onset cancer (diagnosed under 50 years of age) is associated with aggressive disease characteristics and its rising incidence is a global concern. The association between healthy lifestyle and early-onset cancer and whether it varies by common genetic variants is unknown. Objective To examine the associations between genetic risk, lifestyle, and risk of early-onset cancers. Design, Setting, and Participants We analyzed a prospective cohort of 66,308 white British participants who were under age 50 and free of cancer at baseline in the UK Biobank. Exposures Sex-specific composite total cancer polygenic risk scores (PRSs), a breast cancer-specific PRS, and sex-specific health-associated lifestyle scores (HLSs, which summarize smoking status, body mass index [males only], physical activity, alcohol consumption, and diet). Main Outcomes and Measures Hazard ratios (HRs) and 95% confidence intervals (CIs) for early-onset total and breast cancer. Results A total of 1,247 incident invasive early-onset cancer cases (female: 820, male: 427, breast: 386) were documented. In multivariable-adjusted analyses with 2-year latency, higher genetic risk (highest vs. lowest tertile of PRS) was associated with significantly increased risks of early-onset total cancer in females (HR, 95% CI: 1.85, 1.50-2.29) and males (1.94, 1.45-2.59) as well as early-onset breast cancer in females (3.06, 2.20-4.25). An unfavorable lifestyle (highest vs. lowest category of HLS) was associated with higher risk of total cancer and breast cancer in females across genetic risk categories; the association with total cancer was stronger in the highest genetic risk category than the lowest: HRs in females and men were 1.85 (1.02, 3.36), 3.27 (0.78, 13.72) in the highest genetic risk category and 1.15 (0.44, 2.98), 1.16 (0.39, 3.40) in the lowest. Conclusions and Relevance Both genetic and lifestyle factors were independently associated with early-onset total and breast cancer risk. Compared to those with low genetic risk, individuals with a high genetic risk may benefit more from adopting a healthy lifestyle in preventing early-onset cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic Risk, Health-Associated Lifestyle, and Risk of Early-onset Total Cancer and Breast Cancer

Zhang,

Lindström,

Kraft

et al. 2024

Preprint

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“…Even though the majority of research has focused on the consequences of short-term exposures, it has been proposed that long-term exposure may be more significant in terms of overall public health, and two prospective cohort studies imply the new trend for long-term exposure studies [96][97][98][99][100][101][102]. The first investigation, the 1993 Harvard Six Cities study by Dockery et al [63], a cohort of 8111 people with 14 to 16 years of follow-up, revealed that the overall death rate ratio for the most polluted city relative to the least polluted city was 1.26.…”

Section: Miller Et Al'smentioning

confidence: 99%

Health effects of outdoor air pollutants

Bostan

2022

WJER

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One of the most common causes of death and sickness worldwide is cardiovascular disease. A growing body of research suggests that exposure to air pollution increases the risk of cardiovascular disease. Especially children, the elderly, pregnant women, and those from lower socioeconomic backgrounds are more susceptible to the impacts of air pollution. This study aims to explore the health effects of pollutants on the cardiovascular system and respiratory systems. This study follows a literature study method. The study found that exposure to outdoor air pollution is related to immediate and chronic health consequences, from mild physiologic abnormalities to death, especially from respiratory and cardiovascular illnesses. Chemical air pollutants harm patients, especially with chronic respiratory and cardiac disorders, but also asthmatic youngsters. Short-term exposure worsens chronic diseases, and increases symptoms, medical care needs, and mortality, while long-term, repetitive exposure enhances the cumulative risk of these diseases and death. Keywords:Air pollutants, Cardiovascular system, Respiratory system.

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“…Furthermore, nitrogen oxides could enter the human body through inhalation, skin contact, and ingestion, 4 thus causing harm to humans. 5–7 Countries worldwide have set increasingly stringent emission standards to reduce NO x emissions. 8–10 Many technologies have been developed to reduce NO x emissions, among which selective catalytic reduction (SCR) with NH 3 as the reducing agent was the most mature and effective method, especially for stationary sources of NO x emissions.…”

Section: Introductionmentioning

confidence: 99%

Low-temperature selective catalytic reduction of NO with NH₃ over an FeO_x/β-MnO₂ composite

Cheng

et al. 2023

RSC Adv.

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Association of outdoor air pollution, lifestyle, genetic factors with the risk of lung cancer: A prospective cohort study

Cited by 28 publications

References 56 publications

Genetic Risk, Health-Associated Lifestyle, and Risk of Early-onset Total Cancer and Breast Cancer

Genetic Risk, Health-Associated Lifestyle, and Risk of Early-onset Total Cancer and Breast Cancer

Health effects of outdoor air pollutants

Low-temperature selective catalytic reduction of NO with NH₃ over an FeO_x/β-MnO₂ composite

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Association of outdoor air pollution, lifestyle, genetic factors with the risk of lung cancer: A prospective cohort study

Cited by 28 publications

References 56 publications

Genetic Risk, Health-Associated Lifestyle, and Risk of Early-onset Total Cancer and Breast Cancer

Genetic Risk, Health-Associated Lifestyle, and Risk of Early-onset Total Cancer and Breast Cancer

Health effects of outdoor air pollutants

Low-temperature selective catalytic reduction of NO with NH3 over an FeOx/β-MnO2 composite

Contact Info

Product

Resources

About

Low-temperature selective catalytic reduction of NO with NH₃ over an FeO_x/β-MnO₂ composite