Association of parental depression with offspring attention deficit hyperactivity disorder and autism spectrum disorder: A nationwide birth cohort study

Chen, Li Chi; Chen, Mu Hong; Hsu, Ju Wei; Huang, Kou‐Yuan; Bai, Ya Mei; Chen, Tzeng Ji; Wang, Pei Wen; Pan, Tai‐Long; Su, Tung Ping

doi:10.1016/j.jad.2020.07.059

Cited by 50 publications

(30 citation statements)

References 41 publications

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“…The finding that offspring of parents with major depressive disorder presented with higher rates of ADHD is consistent with previous studies suggesting that both paternal depression and maternal depression increase offspring ADHD and ASD risks, and these risks increase further with a longer duration of parental depression and with the additive effect of parental and maternal depression (Chen et al, 2020;Wolford et al, 2017). A meta-analysis showed that parents of children with ADHD had a higher major depressive disorder risk than did those of children without ADHD (Rasic et al, 2014) and longitudinal studies suggest that people with childhood ADHD are more likely to develop depressive symptoms in adolescence (Rice et al, 2019) or in adulthood (Meinzer et al, 2016).…”

Section: Discussionsupporting

confidence: 91%

Attention-deficit/hyperactivity disorder and other neurodevelopmental disorders in offspring of parents with depression and bipolar disorder

et al. 2021

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Background Offspring of parents with major mood disorders (MDDs) are at increased risk for early psychopathology. We aim to compare the rates of neurodevelopmental disorders in offspring of parents with bipolar disorder, major depressive disorder, and controls. Method We established a lifetime diagnosis of neurodevelopmental disorders [attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, communication disorders, intellectual disabilities, specific learning disorders, and motor disorders] using the Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime Version in 400 participants (mean age 11.3 + s.d. 3.9 years), including 93 offspring of parents with bipolar disorder, 182 offspring of parents with major depressive disorder, and 125 control offspring of parents with no mood disorder. Results Neurodevelopmental disorders were elevated in offspring of parents with bipolar disorder [odds ratio (OR) 2.34, 95% confidence interval (CI) 1.23–4.47, p = 0.010] and major depressive disorder (OR 1.87, 95% CI 1.03–3.39, p = 0.035) compared to controls. This difference was driven by the rates of ADHD, which were highest among offspring of parents with bipolar disorder (30.1%), intermediate in offspring of parents with major depressive disorder (24.2%), and lowest in controls (14.4%). There were no significant differences in frequencies of other neurodevelopmental disorders between the three groups. Chronic course of mood disorder in parents was associated with higher rates of any neurodevelopmental disorder and higher rates of ADHD in offspring. Conclusions Our findings suggest monitoring for ADHD and other neurodevelopmental disorders in offspring of parents with MDDs may be indicated to improve early diagnosis and treatment.

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Section: Discussionsupporting

confidence: 91%

Attention-deficit/hyperactivity disorder and other neurodevelopmental disorders in offspring of parents with depression and bipolar disorder

et al. 2021

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“…Depressive symptoms at baseline had the most powerful predictive effect on depressive symptoms at follow-up. Parental depressive disorders increase the risk of offspring ADHD [18,60,61]; the high comorbidity of parental depressive disorders and child ADHD can be the biological result of familial aggregation. Because of the negative effects of depressive problems on the health of caregivers and children with ADHD, depressive symptoms in the caregivers of children with ADHD warrants early identification and intervention.…”

Section: Caregivers' Depressive Symptomsmentioning

confidence: 99%

Predictors of Depressive Symptoms in Caregivers of Children with Attention-Deficit/Hyperactivity Disorder: A One-Year Follow-Up Study

Chou

Hsiao

Chang

et al. 2021

IJERPH

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This 1-year follow-up study examined the predictive values of the demographics, depressive symptoms, stress-coping orientations, and perceived family support of caregivers as well as the internalizing, externalizing and ADHD symptoms of children with attention-deficit/hyperactivity disorder (ADHD) at baseline on the depressive symptoms of the caregivers after 1 year. A total of four hundred caregivers of children with ADHD were recruited. The baseline levels of the caregivers’ depressive symptoms, stress-coping orientations, and perceived family support and the internalizing and externalizing problems of the children were assessed using the Center for Epidemiological Studies Depression Scale, the Coping Orientation to Problems Experienced, Family Adaptation, Partnership, Growth, Affection, Resolve Index, and the Child Behavior Checklist For Ages 6–18, respectively. Their predictions for the caregiver’s depressive symptoms 1 year after the baseline were examined using linear regression analysis. In total, 382 caregivers of children with ADHD underwent the follow-up assessment 1 year from the baseline. A marital status of being separated or divorced, less effective coping and depressive symptoms orientation, and children with internalizing problems and ADHD symptoms at baseline were positively associated with the caregivers’ depressive symptoms at follow-up, whereas the caregivers’ perceived family support and an emotion-focused coping orientation at baseline were negatively associated with depressive symptoms at follow-up. Multiple characteristics of the caregivers and children with ADHD at baseline predicted the caregivers’ depressive symptoms 1 year later.

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“…On the other hand, recent research suggests that neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are common in children and adolescents with GD (13,(29)(30)(31). Maternal prenatal stress, maternal pre and postnatal depression, risk of miscarriage, and prematurity are risk factors associated with ASD and/or ADHD (32)(33)(34)(35). Therefore we suggest that pre, peri, and postnatal factors merit researchers' attention as possible etiological factors shared by GD and neurodevelopmental disorders.…”

Section: Discussionmentioning

confidence: 99%

Cinsiyet Hoşnutsuzluğu Belirtileri Gösteren Çocuklarda Demografik ve Klinik Özellikler: Bir Türkiye Örneklemi

GÜNEŞ

Kayaalp

2022

Türkiye Çocuk Hast Derg

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Objective: In this study, we aim to describe the demographic and clinical characteristics and psychological functioning of children with gender dysphoria (GD) symptoms aged between 3-12 years. Material and Methods: The study group included 20 children (17 males, 3 females; mean age 6.63±2.43 years) with GD symptoms. A sociodemographic data form was used to collect data with regards to demographic and clinical characteristics, and pre- peri-and postnatal features. The Child Behavior Checklist (CBCL) is used to assess behavioral and emotional problems in the child. Results: The boy/girl ratio in the study group was 5.66. The mean age at onset of gender-nonconforming behaviors was 2.85±1.17 years and the mean age of admission to our clinic was 5.82±2.27 years. 20% of the mothers reported a preference for an opposite-sex child prior to conception; 20 % of the mothers reported prenatal stress, 20% of the mothers had prenatal and 25% had postnatal depressive symptoms. There was a risk of miscarriage in 10% of children and 25% were born prematurely. 55% of our study sample exceeded the clinical threshold for internalizing problems and 40% exceeded the clinical threshold for externalizing problems in CBCL ratings. Conclusion: There were more prepubertal boys than girls referred for GD symptoms and the age at referral was younger compared to western countries. In addition, findings of this study indicate that children with GD have poorer psychological functioning possibly due to social intolerance for cross-gender behaviors and/or interests alongside the GD per se.

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Association of parental depression with offspring attention deficit hyperactivity disorder and autism spectrum disorder: A nationwide birth cohort study

Cited by 50 publications

References 41 publications

Attention-deficit/hyperactivity disorder and other neurodevelopmental disorders in offspring of parents with depression and bipolar disorder

Attention-deficit/hyperactivity disorder and other neurodevelopmental disorders in offspring of parents with depression and bipolar disorder

Predictors of Depressive Symptoms in Caregivers of Children with Attention-Deficit/Hyperactivity Disorder: A One-Year Follow-Up Study

Cinsiyet Hoşnutsuzluğu Belirtileri Gösteren Çocuklarda Demografik ve Klinik Özellikler: Bir Türkiye Örneklemi

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