Association of perchlorate, thiocyanate, and nitrate with dyslexic risk

Zhu, Kaiheng; Wan, Yanjian; Zhu, Bing; Wang, Haoxue; Liu, Qi; Xie, Xinyan; Jiang, Qi; Feng, Yanan; Xiao, Pei; Xiang, Zhen; Song, Ranran

doi:10.1016/j.chemosphere.2023.138349

Cited by 7 publications

(1 citation statement)

References 66 publications

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“…An increasing number of studies are beginning to explore the association between exposure to chemicals and dyslexia. So far, eight epidemiological studies have suggested a significant association between exposure to metals [ 15 – 18 ], organophosphate (OP) insecticides [ 19 ], propylene oxide [ 20 ], and sodium iodide symporter (NIS) inhibitors [ 21 ] with the risk of dyslexia (summarized in Table S1 ). However, no similar results have been found for air pollutants [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Developmental dyslexia genes are selectively targeted by diverse environmental pollutants

Yang,

Zheng,

Tang

et al. 2024

BMC Psychiatry

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Background Developmental dyslexia, a complex neurodevelopmental disorder, not only affects children’s academic performance but is also associated with increased healthcare costs, lower employment rates, and reduced productivity. The pathogenesis of dyslexia remains unclear and it is generally considered to be caused by the overlap of genetic and environmental factors. Systematically exploring the close relationship between exposure to environmental compounds and susceptibility genes in the development of dyslexia is currently lacking but high necessary. Methods In this study, we systematically compiled 131 publicly reported susceptibility genes for dyslexia sourced from DisGeNET, OMIM, and GeneCards databases. Comparative Toxicogenomics Database database was used to explore the overlap between susceptibility genes and 95 environmental compounds, including metals, persistent organic pollutants, polycyclic aromatic hydrocarbons, and pesticides. Chemical bias towards the dyslexia risk genes was taken into account in the observation/expectation ratios > 1 and the corresponding P value obtained by hypergeometric probability test. Results Our study found that the number of dyslexia risk genes targeted by each chemical varied from 1 to 109. A total of 35 chemicals were involved in chemical reactions with dyslexia-associated genes, with significant enrichment values (observed/expected dyslexia risk genes) ranging from 1.147 (Atrazine) to 66.901 (Dibenzo(a, h)pyrene). Conclusion The results indicated that dyslexia-associated genes were implicated in certain chemical reactions. However, these findings are exploratory, and further research involving animal or cellular experiments is needed.

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