Association of Periodontal Diseases and Metabolic Syndrome

Mounika, S.; G, Savitha

doi:10.5958/0974-360x.2015.00166.3

Cited by 7 publications

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“…The metabolic syndrome (MetS) is a common and a very important public health issue, worldwide. MetS confers a 5-fold rise in the risk of type 2 diabetes mellitus and 2-fold rise in the development of cardiovascular disease (CVD) over the next 5-10 years [1][2][3]. MetS is a type of disorder which includes a group of multiple metabolic abnormalities in a person.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Inflammatory Status in Metabolic Syndrome

Krishna

Anitha

2018

Asian J Pharm Clin Res

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Objective: The aim of the present study was to assess the level of inflammation in metabolic syndrome (MetS) individuals by estimating C-reactive protein (CRP) in the individuals.Methods: A total of 60 subjects were selected from those attending the outpatient department of a private hospital and divided into two groups (n=30): Group 1 - healthy individuals and Group 2 - individuals with MetS. Informed consent was obtained from the subjects before sample collection. 5 ml of fasting venous blood was collected and centrifuged at 3000 rpm to separate serum, and then, it was analyzed for fasting blood sugar (FBS) by glucose oxidase-peroxidase method, serum triglycerides (TGL) by colorimetric enzymatic method, and serum CRP by Turbilatex method using ERBA CHEM 5 plus analyzer.Results: Mean body mass index level in control and MetS group is 22.73±2.14 and 35.53±3.57, respectively. Mean FBS levels in the control group and MetS group are 85.6±11.59 and 115.67±24.52, respectively. Mean TGL levels in the normal control group and MetS group are 105.63±30.26 and 181.07±47.76, respectively. Mean CRP levels in the normal control and MetS group are 3.17±1.22 and 8.34±2.48, respectively.Conclusion: CRP level positively correlated with MetS. Evaluation of CRP can be used as a surrogate marker to assess the inflammatory status of MetS individuals.

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Section: Introductionmentioning

confidence: 99%

Assessment of Inflammatory Status in Metabolic Syndrome

Krishna

Anitha

2018

Asian J Pharm Clin Res

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Effect of Vitamin D Supplementation in patients with Cardiometabolic disorders- A Clinical Study in Ahmedabad population

Basu

Mehta

2022

RJPT

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Vitamin D deficiency and cardiometabolic disorders are very much widespread in worldwide, India and Ahmedabad region of Gujarat. It was the first study conducted among Gujarati ethnic group of Ahmedabad region, India. The aim of the study was to assess the effects of vitamin D supplementation on cardiometabolic disorders with vitamin D deficiency. The study was performed as an open labeled, randomized, parallel-group, single centric and prospective design at Tej Hospital, Ahmedabad, Gujarat. The dosage regimen of vitamin D supplementation was 60,000 IU/ week for 4 weeks and then 60,000IU once a month for 12 months. Our results showed that vitamin D supplementation causes significant decrease in systolic blood pressure (SBP) at 6 and 12 months as well as significant decrease in triglycerides (TG),very low density lipoprotein (VLDL), fasting blood glucose (FBG), post prandial blood glucose (PPBG) and glycosylated haemoglobin ( HbA1c) with significant increase in 25(OH)D level in vitamin D group at 12 months as compared with non-vitamin D group .Our findings supported that vitamin D deficiency may be a potential risk factor for cardiometabolic disorders and the dosage regimen of vitamin D supplementation is enough to achieve sufficiency and maintain 25(OH)D level which ultimately causes improvement in cardiometabolic disorders.

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Development and qualitative evaluation of periodontal gel containing an antibacterial agent for periodontal disease

Tiwari

Singh

Shekhar³

et al. 2022

RJPT

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The present study aims at the development and evaluation of dental gel containing metronidazole non-biodegradable polymers for targeted delivery of drug and thus prolonging the action. Hot Method was used for the preparation of gel. Natural polymers like, Guar gum, Sodium alginate, Chitosan, Xanthan gum, Gellan gum were used in the formulations of gel. Prepared gels were evaluated for pH, rheological study, spreadability study, gelation, and gel melting study. At last Field Emission Scanning Electron Microscopy FESEM, Differential Scanning Calorimetry (DSC), Thermo Gravimetric Analysis (TGA), Texture Profile Analysis (TPA) have been done on an optimized gel formulation. All gels revealed pH ranged between 6.16 to 6.47, spreadability between 28.37 to 45.03 g.cm/sec, drug content between 90.01 to 99.10 % viscosity ranged between 3108.44 cps and 3645.47 cps and formulations F3 and F10 showed gelation temperature 39±0.12OC and 37±0.13OC respectively which is similar to the temperature of the body. Surface of the sample gels showed no drug particles, indicating a homogeneous mixture of polymers of drugs as well as natural agents. Formulation F10 containing Guar gum showed slower degradation in all media as compared to gels made of Sodium alginate, Xanthan gum, Chitosan, Gellan gum. DSC results revealed that the drug has the same state in the optimized formulation. TGA results showed that the formulation was found to have high stability in high-temperature settings. TPA results of optimized F10 revealed the parameters Mucoadhesive strength 92.54 ± 2.65 g, Hardness 25.34 ± 0.01N/mm², Compressibility 57.75 ± 0.40N mm, Adhesiveness−4.56 ± 0.26 N mm, Cohesiveness 0.83 ± 0.06. Hence, it is concluded that Metronidazole gel with gellan gum showed a longer degradation time and guar gum showed slower degradation in all over polymers used in gel formulations.

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Association of Periodontal Diseases and Metabolic Syndrome

Cited by 7 publications

References 0 publications

Assessment of Inflammatory Status in Metabolic Syndrome

Assessment of Inflammatory Status in Metabolic Syndrome

Effect of Vitamin D Supplementation in patients with Cardiometabolic disorders- A Clinical Study in Ahmedabad population

Development and qualitative evaluation of periodontal gel containing an antibacterial agent for periodontal disease

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