Association of Plasma Brain Natriuretic Peptide with Severity of Acute Ischemic Stroke

Agarwalla, Ajay Kumar; Miah, Md Bahadur Ali; Dey, Subash Kanti; Islam, Md. Rafiqul; Islam, Md Zahidul; Hasan, Md. Rakibul; Islam, Md. Kamrul; Huq, Muhammad Rezeul

doi:10.3329/bjn.v34i2.57552

Cited by 1 publication

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“…NT-pro BNP levels were also found to be raised in ischemic stroke patients and in some studies, it was used as a novel prognostic biomarker of acute ischemic stroke [7][8][9][10]. There was a previous study done in Bangladesh showing the association between plasma BNP and ischemic stroke [11]. As far as our best knowledge, the association between serum NT-proBNP and acute ischemic stroke is yet to be seen in the Bangladeshi population.…”

Section: Introductionmentioning

confidence: 99%

Association between N-terminal Pro-Brain Natriuretic Peptide and Acute Ischemic Stroke in Male Patients

Sultana,

Huq,

Malek

et al. 2023

JAMMR

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Aims: Stroke is among the major cause of mortality and disability globally. Many types of research are ongoing in search of a reliable biomarker for acute ischemic stroke. This study was aimed to see the association of the serum N-terminal proBNP (pro-brain natriuretic peptide) or NT-proBNP with acute ischemic stroke. Study Design: Case-control study. Methodology: This case-control study was conducted from January 2023 to June 2023. A total of 30 acute ischemic stroke male patients were enrolled as cases with 30 healthy male controls. Serum NT-proBNP level was measured in all the participants. Clinical features including the National Institute of Health Stroke (NIHSS) scale score were recorded in cases. Results: The mean ages of the cases and controls were 61 ± 9.22 and 62.40 ± 8.23 years respectively. Among the acute ischemic stroke patients, more than half of the patients (53%) had lacunar stroke. According to the NIHSS score, more than 90% of the patients had minor or moderate stroke (93.3%). The mean NT-proBNP of cases was significantly higher than the controls (266.99 ± 357.88 vs 46.32 ± 18.59) (P = .04). The mean logNT-proBNP level (1.96 ± 0.72) was also significantly higher among the cases than the controls (1.61 ± 0.22) (P = .04). We did not find any association of serum logNTpro-BNP with the duration of stroke (P = .40). There was also no statistically significant association between the NIHSS score and NT-proBNP or logNTpro-BNP levels (P = .36). Conclusion: Serum NT-proBNP level was significantly higher in acute ischemic stroke patients. There was no association of NT-proBNP level with the stroke severity and duration.

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