Association of plasma hormones, nutritional status, and stressful life events in anorexia nervosa patients

Śmiarowska, Małgorzata; Safranow, Krzysztof; Dziedziejko, Violetta; Białecka, Monika; Koziołek, Monika; Samochowiec, Jerzy

doi:10.5604/17322693.1088743

Cited by 11 publications

(4 citation statements)

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“…In underweight AN patients levels of leptin in plasma and cerebrospinal fluid are significantly lower than normal and correlated with BMI [68,69] . Leptin levels were similar in restrictive and binging/purging AN, suggesting that cachexia plays an important role in leptin changes in anorexia [70] .…”

Section: Leptin and Mental Disordersmentioning

confidence: 85%

Peptides from adipose tissue in mental disorders

Wędrychowicz

Zając

Pilecki

et al. 2014

WJP

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Adipose tissue is a dynamic endocrine organ that is essential to regulation of metabolism in humans. A new approach to mental disorders led to research on involvement of adipokines in the etiology of mental disorders and mood states and their impact on the health status of psychiatric patients, as well as the effects of treatment for mental health disorders on plasma levels of adipokines. There is evidence that disturbances in adipokine secretion are important in the pathogenesis, clinical presentation and outcome of mental disorders. Admittedly leptin and adiponectin are involved in pathophysiology of depression. A lot of disturbances in secretion and plasma levels of adipokines are observed in eating disorders with a significant impact on the symptoms and course of a disease. It is still a question whether observed dysregulation of adipokines secretion are primary or secondary. Moreover findings in this area are somewhat inconsistent, owing to differences in patient age, sex, socioeconomic status, smoking habits, level of physical activity, eating pathology, general health or medication. This was the rationale for our detailed investigation into the role of the endocrine functions of adipose tissue in mental disorders. It seems that we are continually at the beginning of understanding of the relation between adipose tissue and mental disorders.

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Section: Leptin and Mental Disordersmentioning

confidence: 85%

Peptides from adipose tissue in mental disorders

Wędrychowicz

Zając

Pilecki

et al. 2014

WJP

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show abstract

“…Central leptin is deleterious to the axial skeleton ( 30 , 31 ) but peripheral leptin has bone anabolic effects with possible osteoclast inhibitory effects ( 32 ). AN is often associated with low leptinemia ( 33 ), probably an adaptive mechanism to increase appetite, and lower leptin levels are associated with lower FM and bone density measures ( 34 ). Furthermore, in a recent study, hypoleptinemia persisted despite the full recovery of FM in an animal model of anorexia ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Bone Mineral Density after Weight Gain in 160 Patients with Anorexia Nervosa

et al. 2017

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Low bone mineral density (BMD) is a frequent complication in anorexia nervosa (AN). There are controversial points of views regarding the restoration of bone mineralization after recovery in AN. We aimed to assess changes of BMD at 3 years in patients with AN and to explore the relationships between body composition, physical activity, and BMD. Patients with AN were included from 2009 to 2011 in a first visit (T0) with evaluation of weight, height, body mass index (BMI), body composition [fat mass (FM) and fat-free mass], and BMD. Those who had low BMD, either osteoporosis or osteopenia, were admitted in a second visit (T1) to carry out a new bone densitometry examination and body composition; they were also asked for their physical activity. At T0, our study involved 160 patients. Low BMD was observed in 53.6% of them and significant factors associated with demineralization were lower BMIs (16.5 ± 2.1 vs 17.3 ± 2.3 kg/m2, p = 0.01) and higher duration of AN (11.4 ± 10.5 vs 6.4 ± 6.5 years, p = 0.001). At 3 years follow-up (T1), 42 patients were involved and no significant changes in BMD were observed despite body weight increase (3.8 ± 6.1 kg). Interestingly, FM gain was a significant factor associated with BMD improvement at follow-up (8.0 ± 9.1 vs 3.0 ± 3.5 kg, p = 0.02). Our findings suggest that the restoration of normal bone values is not related to the increase of body weight, at least after 3 years. FM seems to play an important role in the pathophysiological mechanism of osteoporosis and osteopenia in AN.

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“…In contrast, plasma concentrations of the catabolic adiponectin ( 39 ) and of the steroid hormone-binding protein ( 54 ) tend to be increased by ER. Probably, increased steroid hormone-binding protein levels contribute to the reduced availability of gonadal steroids like testosterone and oestradiol as observed in human subjects undergoing ER regimens ( 55 , 56 ) . Similar to leptin, insulin and testosterone, triiodothyronine (T3) consistently declined in rodents ( 57 ) , primates ( 58 ) and human subjects ( 28 , 59 , 60 ) upon ER feeding.…”

Section: Energy Restriction and Lifespan In Model Organismsmentioning

confidence: 99%

Energy restriction and potential energy restriction mimetics

et al. 2015

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Energy restriction (ER; also known as caloric restriction) is the only nutritional intervention that has repeatedly been shown to increase lifespan in model organisms and may delay ageing in humans. In the present review we discuss current scientific literature on ER and its molecular, metabolic and hormonal effects. Moreover, criteria for the classification of substances that might induce positive ER-like changes without having to reduce energy intake are summarised. Additionally, the putative ER mimetics (ERM) 2-deoxy-d-glucose, metformin, rapamycin, resveratrol, spermidine and lipoic acid and their suggested molecular targets are discussed. While there are reports on these ERM candidates that describe lifespan extension in model organisms, data on longevity-inducing effects in higher organisms such as mice remain controversial or are missing. Furthermore, some of these candidates produce detrimental side effects such as immunosuppression or lactic acidosis, or have not been tested for safety in long-term studies. Up to now, there are no known ERM that could be recommended without limitations for use in humans.

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Association of plasma hormones, nutritional status, and stressful life events in anorexia nervosa patients

Abstract: The changed activity of the somatotropin-somatomedin, gonadal, and corticotrophin axes corresponds to the clinical stage of AN. Plasma IGF-1 seems to be the most sensitive and useful independent hormonal marker of cachexia.

Cited by 11 publications

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Peptides from adipose tissue in mental disorders

Peptides from adipose tissue in mental disorders

Bone Mineral Density after Weight Gain in 160 Patients with Anorexia Nervosa

Energy restriction and potential energy restriction mimetics

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