Association of plasma β-amyloid 40 and 42 concentration with type 2 diabetes among Chinese adults

Peng, Xiaobo; Xu, Zihui; Mo, Xiaoxing; Guo, Qianqian; Yin, Jiawei; Xu, Mengdai; Zhao, Peng; Sun, Taoping; Zhou, Li; Peng, Xiaolin; Xu, Shuai; Yang, Wei; Bao, Wei; Shan, Zhilei; Li, Xiaoqin; Liu, Liegang

doi:10.1007/s00125-020-05102-x

Cited by 8 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was a negative correlation between Mir-155 levels and diabetes patients with different levels of obesity. Peng et al (23) statistically compared the changes of Aβ1-42 levels in diabetic patients and the control group, and the results showed that the risk of diabetes increased with the increase of Aβ1-42 levels, and the two were positively correlated. The results of this study showed that PPAR γ and Mir-155 levels were negatively correlated with pre-diabetes, mild and moderate diabetes, while Aβ1-42 was positively correlated with pre-diabetes, mild and moderate diabetes.…”

Section: Predictive Efficacy Of Pparγ Aβ1-42 and Mir-155 Levels On The Occurrence And Development Of Diabetes Mellitusmentioning

confidence: 99%

Study on the correlation between PPARγ, Aβ1-42, miR-155 and the occurrence and development of diabetes

Wang²,

Yu³

2022

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

The objective of this research was to study the correlation between PPARγ, Aβ1-42, miR-155 and the occurrence and development of diabetes. For this purpose, 52 patients with diabetes who were hospitalized from September 2019 to May 2021 were selected as the research objects. They were grouped according to the severity of the disease, which was pre-diabetes (n=16), mild (n=25), and moderate (n=16). =11), another 20 healthy subjects were taken as the control group, and the levels of PPARγ, Aβ1-42, miR-155 in each group were measured, and the correlation between changes in the levels of various indicators and the occurrence and development of diabetes was explored. Results showed that comparison of age, gender, course of disease, BMI, living habits, comorbidities, and high-density lipoprotein among the groups of diabetic patients (P>0.05); the levels of total cholesterol, triglycerides and low-density cholesterol decreased with the development of diabetes (P<0.05) ); Compared with the healthy group, the levels of PPARγ and miR-155 were significantly reduced, and the levels of Aβ1-42 were significantly increased (P<0.05); compared with the prediabetes, the levels of mild and moderate PPARγ and miR-155 showed a downward trend, and Aβ1 -42 level showed an upward trend (P<0.05); PPARγ and miR-155 levels were negatively correlated with pre-diabetes, mild, and moderate; Aβ1-42 was positively correlated with pre-diabetes, mild, and moderate (P<0.05) ; PPARγ, Aβ1-42, miR-155 levels can effectively predict the occurrence and development of diabetes, and the sensitivity, specificity and accuracy of the detection of diabetes by various indicators, positive predictive value and negative predictive value are significantly higher. It is concluded that PPARγ, Aβ1-42, miR-155 are closely related to the occurrence and development of diabetes, and there are many influencing factors of diabetes. Clinical intervention measures can be taken according to specific conditions.

show abstract

Section: Predictive Efficacy Of Pparγ Aβ1-42 and Mir-155 Levels On The Occurrence And Development Of Diabetes Mellitusmentioning

confidence: 99%

Study on the correlation between PPARγ, Aβ1-42, miR-155 and the occurrence and development of diabetes

Wang²,

Yu³

2022

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

show abstract

“…The EZSZ was initiated to investigate the impacts of nutrition, lifestyle, and genetic factors with chronic diseases in Ezhou and Shenzhen city (in China). Ezhou cohort had been described in our previous report [31]. Briefly, between 2013 and 2015 in Ezhou and between 2017 and 2020 in Shenzhen, 9328 adult residents were enrolled for a baseline investigation.…”

Section: Study Populationmentioning

confidence: 99%

Inverse Association of Plasma Molybdenum with Metabolic Syndrome in a Chinese Adult Population: A Case-Control Study

Huang

Luo

et al. 2021

Nutrients

Self Cite

View full text Add to dashboard Cite

Molybdenum has been found to be associated with metabolic disorders. However, the relationship between molybdenum and metabolic syndrome (MetS) is still unclear. A large case-control study was conducted in a Chinese population from the baseline of Ezhou-Shenzhen cohort. A total of 5356 subjects were included with 2678 MetS and 2678 controls matched by sex and age (±2 years). Medians (IQRs) of plasma molybdenum concentrations were 1.24 μg/L for MetS cases and 1.46 μg/L for controls. After adjustment for multiple covariates, the odds ratio (OR) and 95% confidence intervals (CIs) for MetS were 1.00 (reference), 0.71 (0.59–0.84), 0.56 (0.46–0.68), and 0.47 (0.39–0.58) across quartiles of plasma molybdenum, and per SD increment of log-transformed molybdenum was associated with a 23% lower risk of MetS. In the spline analysis, the risk of MetS and its components decreased steeply with increasing molybdenum and followed by a plateau when the cutoff point was observed around 2.0 μg/L. The dose-dependent relationship of molybdenum with MetS remained consistent when considering other essential elements in the Bayesian kernel machine regression (BKMR) model. In our study, higher plasma molybdenum was significantly associated with a lower risk of MetS, as well as its components, in a dose-response manner.

show abstract

“…Furthermore, it has Natural and Life Sciences Communications: https://cmuj.cmu.ac.th been demonstrated that plasma Aβ1-42 levels were negatively correlated with the cognitive performance of individuals with mild cognitive impairment (MCI) and individuals with AD (Nakamura et al, 2018). However, studies of Aβ1-42 levels in people with diabetes or in an animal model of diabetes were inconclusive (Peters et al, 2017;Meakin et al, 2020;Peng et al, 2020). In our study, we found that diabetic mice exhibited a decrease in plasma Aβ1-42 levels when compared to control mice and the treatment with metformin normalized the levels of plasma Aβ1-42 in diabetic mice.…”

Section: Discussionmentioning

confidence: 99%

Metformin Mitigates Memory Impairment of Diabetic Mice through Modulation of Plasma Pro-inflammatory Cytokines and Aβ1-42 Levels

Janthakhin¹,

Kingtong²,

Aphibanthammakit³

et al. 2023

NLSC

View full text Add to dashboard Cite

Experimental and clinical studies reported that type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction and promotes the onset of dementia. Metformin is an antihyperglycemic drug used for the treatment of T2DM. A growing number of evidence revealed neuroprotective, antioxidant, and anti-inflammation effects exerted by metformin. The present study aimed to investigate the effect of metformin on cognitive function, systemic proinflammatory cytokines and amyloid-beta 1-42 (Aβ1-42) which is a pathological hallmark of Alzheimer’s disease (AD) in diabetic mice. C57BL/6N mice were divided into the following experimental groups: normal control group (NC); diabetes mellitus group (DM) induced by a high-fat diet combined with streptozotocin (STZ) injection; diabetes mellitus treated with metformin 100 mg/kg (DM+Met). Cognitive performance was evaluated by the novel object recognition test (NORT). Systemic proinflammatory cytokines and Aβ1-42 were assessed by the enzyme-linked immunosorbant assay (ELISA) test. We found that diabetic mice exhibited cognitive impairment in NORT whereas the treatment with metformin restored the cognitive function of diabetic mice. Moreover, diabetic mice presented an increase in plasma IL-6 and TNF-α levels while Aβ1-42 was decreased when compared to NC mice. Nevertheless, the administration of metformin allowed the levels of plasma IL-6, TNF-α, and Aβ1-42 to normalize in diabetic mice. Taken together, our findings suggest that metformin improves the cognitive function of diabetic mice possibly via the modulation of plasma pro-inflammatory cytokines and Aβ1-42 levels. Metformin may potentially be used as a therapeutic agent for patients with T2DM who show cognitive deficits. Keywords: Diabetes mellitus, Cognitive impairments, Pro-inflammatory cytokines, Amyloid-beta, Metformin

show abstract

Association of plasma β-amyloid 40 and 42 concentration with type 2 diabetes among Chinese adults

Cited by 8 publications

References 43 publications

Study on the correlation between PPARγ, Aβ1-42, miR-155 and the occurrence and development of diabetes

Study on the correlation between PPARγ, Aβ1-42, miR-155 and the occurrence and development of diabetes

Inverse Association of Plasma Molybdenum with Metabolic Syndrome in a Chinese Adult Population: A Case-Control Study

Metformin Mitigates Memory Impairment of Diabetic Mice through Modulation of Plasma Pro-inflammatory Cytokines and Aβ1-42 Levels

Contact Info

Product

Resources

About