2021
DOI: 10.3390/nu13124544
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Inverse Association of Plasma Molybdenum with Metabolic Syndrome in a Chinese Adult Population: A Case-Control Study

Abstract: Molybdenum has been found to be associated with metabolic disorders. However, the relationship between molybdenum and metabolic syndrome (MetS) is still unclear. A large case-control study was conducted in a Chinese population from the baseline of Ezhou-Shenzhen cohort. A total of 5356 subjects were included with 2678 MetS and 2678 controls matched by sex and age (±2 years). Medians (IQRs) of plasma molybdenum concentrations were 1.24 μg/L for MetS cases and 1.46 μg/L for controls. After adjustment for multipl… Show more

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Cited by 14 publications
(9 citation statements)
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“…Similarly, LMM chromium species showed the same downward trend among children with obesity without reaching statistical significance. This is in accordance with studies reporting lower cobalt blood levels in children with obesity [ 6 , 10 ], whereas the available literature describes negative associations between obesity and circulating chromium [ 44 , 45 ] and molybdenum [ 46 , 47 ] only within adult populations. The main biological functions of chromium, cobalt, and molybdenum revolve around their participation in the regulation of glucose and lipid metabolism.…”
Section: Discussionsupporting
confidence: 91%
“…Similarly, LMM chromium species showed the same downward trend among children with obesity without reaching statistical significance. This is in accordance with studies reporting lower cobalt blood levels in children with obesity [ 6 , 10 ], whereas the available literature describes negative associations between obesity and circulating chromium [ 44 , 45 ] and molybdenum [ 46 , 47 ] only within adult populations. The main biological functions of chromium, cobalt, and molybdenum revolve around their participation in the regulation of glucose and lipid metabolism.…”
Section: Discussionsupporting
confidence: 91%
“…The consumption of 100 g a day of molybdenum biofortified lettuce, for a total of 12 days, was able to reduce fasting glucose, insulin levels and insulin resistance index in the treated group. These results are consistent, in literature, with a large case control study conducted in the Chinese population in which the higher plasma molybdenum was associated, in a dose-response manner, with reduced fasting plasma glucose and lower risk of metabolic syndrome [ 18 ]. Moreover, in pregnant women, during the late first trimester of pregnancy, lower molybdenum concentrations increased the risk of glucose dysregulation during pregnancy [ 17 ].…”
Section: Discussionsupporting
confidence: 91%
“…Recent studies in humans suggest that molybdenum could exert hypoglycemic effects [ 17 , 18 ]. However, although there are reports on leafy green vegetables biofortification with trace elements [ 19 , 20 , 21 , 22 ] including molybdenum [ 23 , 24 , 25 ], there are no studies about the consumption of biofortified food with molybdenum on glucose homeostasis in individuals and the mechanism of action has never been investigated.…”
Section: Introductionmentioning
confidence: 99%
“…Mo has been reported to improve metabolic syndrome by acting on all of its components, including hypertriglyceridemia and HDL [ 42 ]. We did not observe any differences in triglycerides, total cholesterol, LDL cholesterol, or HDL cholesterol in the intervention group compared with the control group.…”
Section: Discussionmentioning
confidence: 99%