Association of plasminogen activator inhibitor-1 4G5G Polymorphism with risk of diabetic nephropathy and retinopathy: a systematic review and meta-analysis

Dastgheib, Seyed Alireza; Najafi, Farzaneh; Shajari, Ahmad; Bahrami, Reza; Asadian, Fatemeh; Sadeghizadeh‐Yazdi, Jalal; Akbarian, Elahe; Emarati, Seyed Alireza; Neámatzadeh, Hossein

doi:10.1007/s40200-020-00675-1

Cited by 11 publications

(8 citation statements)

References 49 publications

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“…In contrast to our findings, Dastgheib et al (2020) found that the PAI-1 4G5G polymorphism was associated with increased risk of DN and diabetic retinopathy (DR) risk [ 34 ]. Furthermore, Wong et al (2000) concluded that SERPINE1 4G/4G is an independent factor for the development of DN in Chinese patients with T2DM and also exhibits a synergistic effect with the allele D of ACE gene on development of DN [ 27 ].…”

Section: Discussioncontrasting

confidence: 99%

“…Among the numerous genetic loci studied in both individual studies [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ] and meta-analyses [ 32 , 33 , 34 ] is serpin family E member 1 ( SERPINE1 ) gene, also known as Plasminogen activator inhibitor-1 (PAI-1), which is a member of the serine proteinase inhibitor (serpin) superfamily and constitutes the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA) leading to inhibition of fibrinolysis [ 32 ]. The SERPINE1 gene is located at chromosome band 7q22.1.…”

Section: Introductionmentioning

confidence: 99%

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Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach

Tziastoudi

Dardiotis

Pissas

et al. 2021

Genes

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Background: Many lines of evidence highlight the genetic contribution on the development of diabetic nephropathy (DN). One of the studied genes is SERPINE1 whose the role in the risk of developing DN remains questionable. In order to elucidate the contribution of SERPINE1 in DN progression in the context of type 2 diabetes mellitus (T2DM), we conducted an association study and meta-analysis of SERPINE1 genetic variants. Materials and Methods: A total of 190 patients with DN, 150 T2DM (type 2 diabetes mellitus) patients without DN and 238 healthy controls were recruited. We selected five tag single-nucleotide polymorphisms (SNPs) from the HapMap. The generalized odds ratio (ORG) was calculated to estimate the risk on DN development. Subgroup analyses based on ethnicity and type of diabetes were also performed. Results: Both the present association study regarding SERPINE1 SNPs (rs2227667, rs2070682, rs1050813, rs2227690, rs2227692) did not found any significant association between SERPINE1 variants and DN and the meta-analysis of variant 4G>5G (rs1799889) did not also reveal a significant association between 4G>5G variant and DN in main and subgroup analyses. Discussion: In conclusion, the present association study and meta-analysis provides strong evidence that SERPINE1 genetic variant 4G>5G is not implicated in the risk or development of DN in Caucasians. Further studies in other populations remain to further investigate the role of this variant in the course of DN.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach

Tziastoudi

Dardiotis

Pissas

et al. 2021

Genes

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“…Our combined data based on ten studies with 11,755 infected cases and 942 deaths showed that the [21,48,49]. It is well known that allcause mortality rate in patients with DM is higher than in patients without DM [50][51][52]. Our pooled data showed that the proportion of SARS-COV-2 infection in the Iranian patients with DM was 16.3 %.…”

Section: Discussionmentioning

confidence: 68%

Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis

Mirjalili

Dastgheib

Shaker

et al. 2021

J Diabetes Metab Disord

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Background Currently, the number of patients with SARS-COV-2 infection has increased rapidly in Iran, but the risk and mortality of SARS-COV-2 infection in Iranian patients with diabetes mellitus (DM), chronic kidney disease (CKD), hypertension and cardiovascular diseases (CVDs) still not clear. The aim of this meta-analysis was to estimate the proportion and mortality of SARS-COV-2 in these patients. Methods A comprehensive literature search was carried out in PubMed, Web of Sciences, Cochrane Library, EMBASE, CNKI, SciELO, and other databases to identify all relevant studies published up to 10 January, 2020. The proportion and mortality in the patients were assessed by odd ratio (OR) and the corresponding 95 % confidence interval (95 % CI). Results A total of ten case-series including 11,755 cases with SARS-COV-2 infection and 942 deaths were selected. Among them, there were total of 791 DM patients with 186 deaths, 225 CKD patients with 45 deaths, 790 hypertension cases with 86 deaths, and 471 CVDs cases with 60 deaths. Pooled data revealed that the proportion of SARS-COV-2 infection in the patients with hypertension, DM, CVDs and CKD were 21.1 %, 16.3 %, 14.0 % and 5.0 %, respectively. Moreover, the SARS-COV-2 infection were associated with an increased risk of mortality in DM (OR = 0.549, CI 95 % 0.448-0.671, p ≤ 0.001) and CKD (OR = 0.552, 95 % CI 0.367-0.829, p = 0.004) patients, but not hypertension and CVDs. There was no publication bias. Conclusions Our pooled data showed that the proportion of SARS-COV-2 infection was the highest in the Iranian patients with hypertension (21.1 %) followed by DM (16.3 %), CVDs (14.0 %) and CKD (5.0 %). Moreover, DM and CKD in patients with SARS-COV-2 infection were associated with a 0.549 and 0.552-fold increase in mortality, respectively. Clinicians in Iran should be aware of these findings, to identifying patients at higher risk and inform interventions to reduce the risk of death. Moreover, well-designed, large-scale and multicenter studies are needed to improve and validate our findings.

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“…A number of previous studies reported a bidirectional relationship between SARS-CoV-2 and the onset of diabetes [3]. Although diabetes is prevalent worldwide, healthcare professionals are worried about this new pandemic's consequences regarding diabetes [4]. While it has been shown that persons with diabetes (PWD) are considered as high risk population for developing complications [5]; herein, we presented a young patient with new onset diabetes after SARS-CoV-2 infection.…”

Section: Introductionmentioning

confidence: 91%

New onset of diabetes in a child infected with COVID-19: a case report

Ordooei

Behniafard

Soheilipour

et al. 2021

J Diabetes Metab Disord

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Background Diabetic ketoacidosis (DKA) is a serious complication of type 1 diabetes. A few studies have reported that COVID-19 is associated with the development of new-onset diabetes. Here, we present an infected child with new onset diabetes leading to DKA. Case presentation A 10-year-old patient with respiratory distress admitted to the Emergency Department of our center. The patient's COVID-19 Polymerase Chain Reaction (PCR) test was positive and also biochemical analyses confirmed that he had DKA. Despite standard initial treatments, ketoacidosis remained resistant; hence we prescribed oral bicarbonate (40 cc every 8 h) to treat the patient's refractory acidosis. Due to the patient's improvement, he was discharged after 10 days (7 days in the PICU), receiving outpatient enoxaparin (for a week) and ongoing subcutaneous insulin. ConclusionWe report an interesting case of a child with COVID-19 infection precipitating presentation with new onset diabetes. Due to refractory acidosis, starting oral bicarbonate treatment after 2 days improved acidosis and tachypnea in the patient. The patient's medical team suggest close biochemical monitoring, prescribing enoxaparin for high level of D-dimer, and ordering oral bicarbonate acidosis persists.

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Association of plasminogen activator inhibitor-1 4G5G Polymorphism with risk of diabetic nephropathy and retinopathy: a systematic review and meta-analysis

Cited by 11 publications

References 49 publications

Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach

Serpin Family E Member 1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetic Nephropathy: An Association Study and Meta-Analysis Using a Genetic Model-Free Approach

Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis

New onset of diabetes in a child infected with COVID-19: a case report

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