Association of platelet count and serological markers of dengue infection-importance of NS1 antigen

Abstract

Inclusion of NS1 in the diagnosis of dengue increases the detection rate significantly. In cases of fever, thrombocytopenia is more consistently found in dengue positive rather than dengue negative subjects. It correlates well when NS1 and IgM are detected simultaneously.

Seroepidemiology and Gender Related Differences in Laboratory Characteristics of Dengue Virus Infection: A Hospital Based Study, Bhopal

“…75(42.61%) dengue seropositive cases were detected to have thrombocytopenia in our study [ Table 3]. Soumy K et al [17] and Kulkarni RD et al [21] proved a significant association between thrombocytopenia and dengue infection. In the present study, leucopenia was detected in 69 (39.20%) seropositive cases [ Table 3].…”

Serological and Epidemiological Picture of Dengue during the Year 2014: An Exclusive Study of Kutch District, Gujarat, India

“…However almost half (81, 48.8%) patients from total 166 patients who came within 2 days of fever were tested positive for Dengue. This could be due to high sensitivity and specificity of Dengue NS 1 antigen ELISA test which was the sole test selected for patients presents early in acute stage of Dengue (Kulkarni et al, 2011;Peeling et al, 2010).…”

“…In rest of 32 positive cases both NS 1 antigen and Ig M antibody were detected. Various studies have indicated that NS 1 antigen helps in early detection and confirmation of diagnosis (Kulkarni et al, 2011;Datta et al, 2010;Krunal Mehta et al, 2016). When month wise trend was depicted on graph it reinforced the fact that surge in Dengue vector and so the rise in dengue cases occur in Monsoon and post monsoon season (WHO Dengue fever 2nd Edition 1997, Madhulika Mistry et al, 2015;Durani et al, 2014;Piyush tripathi et al, 2008 …”

Thrombocytopenia – An Indicator of Impending Complications in Dengue Virus Infection

“…However, this is not within the reach of peripheral and even most tertiary care laboratories (Peeling et al, 2010;Kulkarni et al, 2011).…”

“…The complications like DHF and DSS are usually attributed to this cross-reactivity in secondary infections (Kulkarni et al, 2011).…”