Association of Polycystic Ovaries with the Use of Valproic Acid in Jordanian Epileptic Patients

Otoom, Sameer; Nusier, Mohamad; Hasan, Mahmudul; Hadidi, H.; Samawi, R.; Younes, Abdallah M.; Darweesh, Mohamed S.; Boulatova, Nailya

doi:10.2165/00044011-200323080-00005

Cited by 6 publications

(1 citation statement)

References 26 publications

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“…In Jordan, It is found that valproic acid was associated with polycystic ovarian syndrome among epileptic patients [18]. It is reported that UGT2B7*2 affected the glucuronidation of valporic acid [8].…”

Section: Discussionmentioning

confidence: 99%

The Frequency of UGT2B7*2 (802C>T) Allele among Healthy Unrelated Jordanian Volunteers

YB¹,

Kherfan²,

Obaid³

2016

J Drug Metab Toxicol

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The UDP-Glucuronesyl Transferase (UGT) 2B7*2 802C>T is the most common functional genetic variant on UGT2B7 gene with reported influence on drug response. Objective: To determine the frequency of UGT2B7*2 (802C>T) genetic variant among Jordanian population. Methods: The DNA samples from 90 healthy Jordanian volunteers were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism assays (PCR-RFLP) to determine the UGT2B7*2 allele. Results: The frequency (95% confidence interval) of UGT2B7*2 802C allele was 0.59 (0.52 to 0.66) and for UGT2B7*2 802T was 0.41 (0.34 to 0.48), which was similar to the Caucasian but different than African ethnic populations. The UGT2B7 genotype frequency among Jordanians was 0.31 (0.22 to 0.4) for wild, 0.57(0.47 to 0.67) for heterozygote and 0.12 (0.06 to 0.18) for homozygote UGT2B7*2 genotype. Conclusion: This study reported for the first time the UGT2B7*2 frequency and genotype profile among Jordanians. The findings of this study will increase our understanding in explaining the inter-individual variation in drug response among Jordanian population.

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Section: Discussionmentioning

confidence: 99%