Association of polymorphisms in estrogen and thyroid hormone receptors with thyroid cancer risk

Rebaı̈, Mohamed; Kallel, Imen; Charfeddine, S.; Hamza, F.; Guermazi, F.; Rebaï, Ahmed

doi:10.1080/10799890902845682

Cited by 25 publications

(20 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the most studied polymorphism is the coding synonymous variant at codon 594 (rs2228480) within the last exon of the gene. This variant is thought to play a role in distinguishing between the receptor agonist or antagonists binding to the receptor molecule [9] and has been suggested, although inconsistently, to be associated with risk of breast cancer [10] and more recently of thyroid cancer [11]. …”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms in the EGFR (R521K) and Estrogen Receptor (T594T) Genes, EGFR and ErbB‐2 Protein Expression, and Breast Cancer Risk in Tunisia

Kallel

Rebaı̈

Khabir

et al. 2009

BioMed Research International

Self Cite

View full text Add to dashboard Cite

We evaluated the association of epidermal growth factor receptor (EGFR) 142285G>A (R521K) and estrogen receptor alpha (ESR1) 2014G>A (T594T) single nucleotide polymorphisms with breast cancer risk and prognosis in Tunisian patients. EGFR 142285G>A and ESR1 2014G>A were genotyped in a sample of 148 Tunisian breast cancer patients and 303 controls using PCR-RFLP method. Immunohistochemitsry was used to evaluate the expression levels of EGFR, HER2, ESR1, progesterone receptor and BCL2 in tumors. We found no evidence for an association between EGFR R521K polymorphism and breast cancer risk. However, we found that the homozygous GG (Arg) genotype was more prevalent in patients with lymph node metastasis (P = .03) and high grade tumors (P = .011). The ESR1 2014G allele showed significant association with breast cancer risk (P = .025). The GG genotype was associated with HER2 overexpression and this association withstood univariate and multivariate analyses (P = .009; P = .021, resp.). These data suggest that the R521K might be a prognostic factor, because it correlates with both tumor grade and nodule status. The higher expression of HER2 in ESR1 T594T GG patients suggests the possibility that ESR1 gene polymorphisms accompanied by HER2 expression might influence the pathogenesis of breast cancers.

show abstract

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms in the EGFR (R521K) and Estrogen Receptor (T594T) Genes, EGFR and ErbB‐2 Protein Expression, and Breast Cancer Risk in Tunisia

Kallel

Rebaı̈

Khabir

et al. 2009

BioMed Research International

Self Cite

View full text Add to dashboard Cite

show abstract

“…Polymorphisms in ESR are also involved in tumor oncogenesis in several tissues (e.g. breast, prostate, ovary and thyroid), and may alter responsiveness of the tissues to estrogens [30]–[33].…”

Section: Discussionmentioning

confidence: 99%

Identification of Thyroid Carcinoma Related Genes with mRMR and Shortest Path Approaches

Deng

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

Thyroid cancer is a malignant neoplasm originated from thyroid cells. It can be classified into papillary carcinomas (PTCs) and anaplastic carcinomas (ATCs). Although ATCs are in an very aggressive status and cause more death than PTCs, their difference is poorly understood at molecular level. In this study, we focus on the transcriptome difference among PTCs, ATCs and normal tissue from a published dataset including 45 normal tissues, 49 PTCs and 11 ATCs, by applying a machine learning method, maximum relevance minimum redundancy, and identified 9 genes (BCL2, MRPS31, ID4, RASAL2, DLG2, MY01B, ZBTB5, PRKCQ and PPP6C) and 1 miscRNA (miscellaneous RNA, LOC646736) as important candidates involved in the progression of thyroid cancer. We further identified the protein-protein interaction (PPI) sub network from the shortest paths among the 9 genes in a PPI network constructed based on STRING database. Our results may provide insights to the molecular mechanism of the progression of thyroid cancer.

show abstract

“…The -106A/G of interleukin 11 receptor-α promoter polymorphism may be associated with PTC risk [14], the 1513A>C polymorphism in the purinergic receptor P2X 7 is strongly associated with the follicular variant of PTC [15]. The polymorphism of IL-6 (G-174 C) , IL-10 (-1082 G/A) , DNA repair gene ( RAD52 ) and estrogen receptor 1 ( rs2228480 ) show significantly associated with PTC [16-19]. …”

Section: Discussionmentioning

confidence: 99%

Association Study of FOS-Like Antigen-2 Promoter Polymorphisms With Papillary Thyroid Cancer in Korean Population

Kim

Chung

et al. 2014

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

ObjectivesFOS-like antigen-2 (FOSL-2), a member of the FOS gene family, encode leucine zipper proteins that can heterodimerize with proteins of Jun family. Thus, activating protein (AP)-1 transcription factor is formed, has a crucial role in proliferation, differentiation and apoptosis of normal tissue as well as oncogenic transformation and progression. We performed an association study of single nucleotide polymorphisms (SNPs) in the FOSL-2 with papillary thyroid cancer (PTC). We also estimated the relationships between the SNPs and the clinicopathologic characteristics of PTC.MethodsOne promoter SNPs (rs925255) of FOSL-2 gene were genotyped with direct sequencing method in 94 PTC and 213 controls. PTC patients were dichotomized and compared with respect to clinical parameters of PTC. Genetic data were analyzed using Helixtree, SNPAnalyzer, SNPStats. Multivariate logistic regression analysis was fulfilled to evaluate the genetic effect with adjustment for age and sex.ResultsSNP (rs925255) in FOSL-2 showed a significant association (codominant 1 model [G/G vs. A/G]: odds ratio [OR], 0.531, 95% confidence interval [CI], 0.293 to 0.96, P=0.036; dominant model: OR, 0.50, 95% CI, 0.28 to 0.89, P=0.015) with PTC. The frequency of allele G in rs925255 was also significantly associated with PTC (OR, 0.59; 95% CI, 0.34 to 0.91; P=0.02). But we fail to prove significant association between this polymorphism (rs925255) and clinico-pathological parameters.ConclusionOur findings suggest that the rs925255 SNP and its allele G show significant association with the PTC in Korean population.

show abstract

Association of polymorphisms in estrogen and thyroid hormone receptors with thyroid cancer risk

Cited by 25 publications

References 31 publications

Genetic Polymorphisms in the EGFR (R521K) and Estrogen Receptor (T594T) Genes, EGFR and ErbB‐2 Protein Expression, and Breast Cancer Risk in Tunisia

Genetic Polymorphisms in the EGFR (R521K) and Estrogen Receptor (T594T) Genes, EGFR and ErbB‐2 Protein Expression, and Breast Cancer Risk in Tunisia

Identification of Thyroid Carcinoma Related Genes with mRMR and Shortest Path Approaches

Association Study of FOS-Like Antigen-2 Promoter Polymorphisms With Papillary Thyroid Cancer in Korean Population

Contact Info

Product

Resources

About