Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis

Abstract

The deficiency of vitamin D has been reported to be relevant to cancer risk. DHCR7 and CYP2R1 are crucial components of vitamin D-metabolizing enzymes. Thus, accumulating researchers are concerned with the correlation between polymorphisms of DHCR7 and CYP2R1 genes and cancer susceptibility. Nevertheless, the conclusions of literatures are inconsistent. We conducted an integrated review for the correlation of DHCR7 and CYP2R1 SNPs with cancer susceptibility. In the meanwhile, a meta-analysis was performed using accessible data to clarify the association between DHCR7 and CYP2R1 SNPs and overall cancer risk. Literatures which meet the rigid inclusion and exclusion criteria were involved. The association of each SNP with cancer risk was calculated by odds ratios (ORs). 12 case-control designed studies covering 23780 cases and 27307 controls were ultimately evolved in the present meta-analysis of five SNPs (DHCR7 rs12785878 and rs1790349 SNP; CYP2R1 rs10741657, rs12794714, and rs2060793 SNP). We found that DHCR7 rs12785878 SNP was significantly related to cancer risk in the whole population, Caucasian subgroup, and hospital-based (HB) subgroup. DHCR7 rs1790349 SNP was analyzed to increase cancer risk in Caucasians. Moreover, CYP2R1 rs12794714-A allele had correlation with a lower risk of colorectal cancer. Our findings indicated that rs12785878, rs1790349, and rs12794714 SNPs might potentially be biomarkers for cancer susceptibility.

Analysis of exosomal competing endogenous RNA network response to paclitaxel treatment reveals key genes in advanced gastric cancer

“…What’s more, we had some novel discoveries of the hub mRNAs in exosomes, such as CYP2R1 and BTLA, that haven’t been reported in exosomes but have important functions. CYP2R1 are crucial components of vitamin D-metabolizing enzymes ( 32 ). Recent results suggested that high vitamin D concentration was associated with a lower odds ratio of GC in Korean adults ( 33 ).…”

A pan-cancer analysis of the oncogenic role of 7-dehydrocholesterol reductase (DHCR7) in human tumors

“…At the same time, 7-DHC is a key substrate for the production of vitamin D3 19 . In recent years, increasing publications have put forth a functional link between DHCR7 and a diverse variety of tumors 5,20 . However, the speci c mechanism or underlying pathway by which DHCR7 promotes the tumorigenesis and tumor progression remains poorly understood.…”

“…Therefore, DHCR7 is considered as a key focus for current tumor research. Although there is clear evidence of that DHCR7 polymorphisms are associated with an increased risk of various tumors, the causal relationship between its abnormal expression with tumorigenesis is still unclear, and its effect on the development of different kinds of tumors and its molecular mechanism are still controversial [5][6][7] .…”

Vitamin D-Related Genes and Thyroid Cancer—A Systematic Review

“…Unfortunately, no other studies have yet searched for the role of this gene in thyroid gland neoplasms. DHCR7 is one of a few genes found to influence 25(OH)D plasma level in GWAS [ 69 ]. Rs12785878 SNP was also found to increase a general cancer risk in a meta-analysis of five studies including patients with breast, hepatocellular, and thyroid cancer [ 69 ].…”